Alpha 2-adrenoceptors mediate inhibition of cyclic AMP production in the spinal cord after stimulation of cyclic AMP with forskolin but not after stimulation with capsaicin or vasoactive intestinal peptide.

Uhlén S, Wikberg JE

Journal of neurochemistry1 Mar 1989Cited by 8 (Europe PMC)

PMID2537376DOI10.1111/j.1471-4159.1989.tb02520.xPepBankPUB-02537376

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In guinea pig spinal cord slices, VIP caused a dose-dependent stimulation of cyclic AMP production.
In plain wordsIn lab tests on guinea pig spinal cord tissue, VIP raised cyclic AMP in a dose-dependent way.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseCyclic AMP production in spinal cord slices
Study
guinea pign: not reported in source
ventral and dorsal spinal cord slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In slices obtained from the ventral and the dorsal guinea pig spinal cord both forskolin and vasoactive intestinal peptide (VIP) caused a dose-dependent stimulation of the production of cyclic AMP.
Report a problemFND-0253737601

Studies that did not test the peptide alone1

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

02LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueMechanism
In guinea pig spinal cord slices, the alpha 2 agonist UK-14,304 was virtually ineffective in inhibiting cyclic AMP formation stimulated with VIP.
In plain wordsIn lab tests on guinea pig spinal cord tissue, an alpha 2 agonist hardly reduced cyclic AMP raised by VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeInhibition by UK-14,304 of VIP-stimulated cyclic AMP
Study
guinea pign: not reported in source
ventral and dorsal spinal cord slices
Comparator
Forskolin-stimulated cyclic AMP
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Also, when the formation of cyclic AMP was stimulated with VIP, UK-14,304 was virtually ineffective in inhibiting the formation of cyclic AMP both in the ventral and the dorsal parts of the cord.
1 context sentence(design, population, supporting numbers)
Summary · context
In slices obtained from the ventral and the dorsal guinea pig spinal cord both forskolin and vasoactive intestinal peptide (VIP) caused a dose-dependent stimulation of the production of cyclic AMP.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0253737602

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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