Correlation between oxytocin neuronal sensitivity and oxytocin receptor binding: an electrophysiological and autoradiographical study comparing rat and guinea pig hippocampus.

Raggenbass M, Tribollet E, Dubois-Dauphin M, Dreifuss JJ

Proceedings of the National Academy of Sciences of the United States of America1 Jan 1989Cited by 35 (Europe PMC)

PMID2536177PMCIDPMC286552DOI10.1073/pnas.86.2.750PepBankPUB-02536177

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In rat hippocampal slices, oxytocin at 50-1000 nM reversibly increased the firing rate of nonpyramidal neurones.
In plain wordsIn rat brain slices, oxytocin made certain nerve cells fire faster, and the effect was reversible.
Peptide
Oxytocin
Outcome
IncreaseFiring rate of nonpyramidal CA1 neurones
Study
ratn: not reported in source
Hippocampal slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50-1000 nMAs given in this study (rat).
Source sentences
Summary
In rats, these neurones responded to oxytocin at 50-1000 nM by a reversible increase in firing rate.
1 context sentence(design, population, supporting numbers)
Summary · context
In transverse hippocampal slices from rat and guinea pig brains, we obtained unitary extracellular recordings from nonpyramidal neurones located in or near the stratum pyramidale in the CA1 field and in the transition region between the CA1 and the subiculum.
Report a problemFND-0253617701
02LabEx vivo tissueMechanism
In guinea pig hippocampal slices, nonpyramidal neurones were unaffected by oxytocin.
In plain wordsIn guinea pig brain slices, oxytocin did not change the activity of these nerve cells.
Peptide
Oxytocin
Outcome
No significant changeFiring rate of nonpyramidal neurones in guinea pig hippocampus
Study
guinea pign: not reported in source
Hippocampal slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In guinea pigs, by contrast, nonpyramidal neurones were unaffected by oxytocin, although they were excited by carbachol.
1 context sentence(design, population, supporting numbers)
Summary · context
In transverse hippocampal slices from rat and guinea pig brains, we obtained unitary extracellular recordings from nonpyramidal neurones located in or near the stratum pyramidale in the CA1 field and in the transition region between the CA1 and the subiculum.
Report a problemFND-0253617703

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

03LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In rat hippocampal slices, a synthetic antioxytocic analogue suppressed the excitation of neurones that oxytocin caused.
In plain wordsIn rat brain slices, a blocking analogue stopped the excitation that oxytocin caused in nerve cells.
Peptide
Oxytocin
Outcome
DecreaseSuppression of oxytocin-induced excitation by an antioxytocic analogue
Study
ratn: not reported in source
Hippocampal slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
The oxytocin-induced excitation was suppressed by a synthetic structural analogue that acts as a potent, selective antioxytocic on peripheral receptors.
1 context sentence(design, population, supporting numbers)
Summary · context
In transverse hippocampal slices from rat and guinea pig brains, we obtained unitary extracellular recordings from nonpyramidal neurones located in or near the stratum pyramidale in the CA1 field and in the transition region between the CA1 and the subiculum.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0253617702
04LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In rat brain, autoradiography with a radioiodinated antioxytocic labelled the subiculum and the CA1 area of the hippocampus.
In plain wordsIn rat brain tissue, a labelled oxytocin blocker bound to parts of the hippocampus.
Peptide
Oxytocin
Outcome
Not applicableAntioxytocic radioligand binding in rat hippocampus
Study
ratn: not reported in source
Hippocampal slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Light microscopic autoradiography, carried out using a radioiodinated selective antioxytocic as a ligand, revealed labeling in the subiculum and in the CA1 area of the hippocampus of rats
1 context sentence(design, population, supporting numbers)
Summary · context
In transverse hippocampal slices from rat and guinea pig brains, we obtained unitary extracellular recordings from nonpyramidal neurones located in or near the stratum pyramidale in the CA1 field and in the transition region between the CA1 and the subiculum.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0253617704
05LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In guinea pig brain, autoradiography detected no oxytocin-binding sites in the hippocampus.
In plain wordsIn guinea pig brain tissue, no oxytocin-binding sites were found in the hippocampus.
Peptide
Oxytocin
Outcome
No significant changeAntioxytocic radioligand binding in guinea pig hippocampus
Study
guinea pign: not reported in source
Hippocampal slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
whereas no oxytocin-binding sites were detected in the hippocampus of guinea pigs.
1 context sentence(design, population, supporting numbers)
Summary · context
In transverse hippocampal slices from rat and guinea pig brains, we obtained unitary extracellular recordings from nonpyramidal neurones located in or near the stratum pyramidale in the CA1 field and in the transition region between the CA1 and the subiculum.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0253617705

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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