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Study · Animal study (in vivo) · mouse · 1989

10 results

[Effect of delta sleep-inducing peptide, anticonvulsant preparations and nicotinamide on generalized seizure activity].

Shandra AA, Godlevskiĭ LS, Mazarati AM, Makul'kin RF

Biulleten' eksperimental'noi biologii i meditsiny1 Feb 1989Cited by 2 (Europe PMC)

PMID2522323 (opens in a new tab)PepBankPUB-02522323
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP increased the latency of the first corazol-induced seizure.

    In plain wordsIn mice, DSIP delayed the first seizure caused by corazol.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSeizure latency, corazol
    Study

    mousen: not reported in source

    chemically induced seizures in F1(CBA X C57 BL/6) mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was shown that DSIP increased the latency of first seizure manifestation which were induced by corazol
    1 context sentence
    Summary · context
    The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP increased the latency of the first bicuculline-induced seizure.

    In plain wordsIn mice, DSIP delayed the first seizure caused by bicuculline.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSeizure latency, bicuculline
    Study

    mousen: not reported in source

    chemically induced seizures in F1(CBA X C57 BL/6) mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was shown that DSIP increased the latency of first seizure manifestation which were induced by corazol, bicuculline and picrotoxin
    1 context sentence
    Summary · context
    The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP increased the latency of the first picrotoxin-induced seizure.

    In plain wordsIn mice, DSIP delayed the first seizure caused by picrotoxin.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSeizure latency, picrotoxin
    Study

    mousen: not reported in source

    chemically induced seizures in F1(CBA X C57 BL/6) mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was shown that DSIP increased the latency of first seizure manifestation which were induced by corazol, bicuculline and picrotoxin
    1 context sentence
    Summary · context
    The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP suppressed the severity of corazol-induced seizures.

    In plain wordsIn mice, DSIP lowered the severity of seizures caused by corazol.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSeizure severity, corazol
    Study

    mousen: not reported in source

    chemically induced seizures in F1(CBA X C57 BL/6) mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    also resulted in a suppression of seizure severity of corazol and bicuculline induced seizures
    1 context sentence
    Summary · context
    The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP suppressed the severity of bicuculline-induced seizures.

    In plain wordsIn mice, DSIP lowered the severity of seizures caused by bicuculline.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSeizure severity, bicuculline
    Study

    mousen: not reported in source

    chemically induced seizures in F1(CBA X C57 BL/6) mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    also resulted in a suppression of seizure severity of corazol and bicuculline induced seizures
    1 context sentence
    Summary · context
    The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice, the anticonvulsant effect of DSIP was most pronounced at doses from 10 to 100 mcg/kg.

    In plain wordsIn mice, the seizure-protective effect of DSIP was strongest within a middle dose range.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDose range of strongest anticonvulsant effect
    Study

    mousen: not reported in source

    chemically induced seizures in F1(CBA X C57 BL/6) mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10-100 mcg/kgAs given in this study (mouse).

    Measurements

    Dose range of strongest effect
    10 to 100 mcg/kg
    DSIP

    Source sentences

    Summary
    The effect of DSIP was mostly pronounced in range of its doses from 10 to 100 mcg/kg.
    1 context sentence
    Summary · context
    The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP enhanced the antiepileptic effect of phenobarbital.

    In plain wordsIn mice, adding DSIP made the seizure-protective effect of phenobarbital stronger.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseAntiepileptic effect of phenobarbital with DSIP
    Study

    mousen: not reported in source

    chemically induced seizures in F1(CBA X C57 BL/6) mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DSIP when combined with phenobarbital, carbamazepine, diphenylhydantoin or nicotinamide enhanced the antiepileptic effects of these anticonvulsant drugs.
    1 context sentence
    Summary · context
    The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP enhanced the antiepileptic effect of carbamazepine.

    In plain wordsIn mice, adding DSIP made the seizure-protective effect of carbamazepine stronger.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseAntiepileptic effect of carbamazepine with DSIP
    Study

    mousen: not reported in source

    chemically induced seizures in F1(CBA X C57 BL/6) mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DSIP when combined with phenobarbital, carbamazepine, diphenylhydantoin or nicotinamide enhanced the antiepileptic effects of these anticonvulsant drugs.
    1 context sentence
    Summary · context
    The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP enhanced the antiepileptic effect of diphenylhydantoin.

    In plain wordsIn mice, adding DSIP made the seizure-protective effect of diphenylhydantoin stronger.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseAntiepileptic effect of diphenylhydantoin with DSIP
    Study

    mousen: not reported in source

    chemically induced seizures in F1(CBA X C57 BL/6) mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DSIP when combined with phenobarbital, carbamazepine, diphenylhydantoin or nicotinamide enhanced the antiepileptic effects of these anticonvulsant drugs.
    1 context sentence
    Summary · context
    The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP enhanced the antiepileptic effect of nicotinamide.

    In plain wordsIn mice, adding DSIP made the seizure-protective effect of nicotinamide stronger.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseAntiepileptic effect of nicotinamide with DSIP
    Study

    mousen: not reported in source

    chemically induced seizures in F1(CBA X C57 BL/6) mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DSIP when combined with phenobarbital, carbamazepine, diphenylhydantoin or nicotinamide enhanced the antiepileptic effects of these anticonvulsant drugs.
    1 context sentence
    Summary · context
    The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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