Effects of psychoactive drugs on delta sleep-inducing peptide concentrations in rat brain.

Wahlestedt C, Ekman R, Heilig M, Widerlöv E

European journal of pharmacology1 Jan 1989Cited by 1 (Europe PMC)

PMID2522052DOI10.1016/0014-2999(89)90159-3PepBankPUB-02522052

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Natural levels measured10

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In rats, three weeks of imipramine reduced DSIP-like immunoreactivity in the hypothalamus, frontal cortex and cerebellum.
In plain wordsIn rats, the antidepressant imipramine lowered the body's own DSIP-like levels in three brain regions.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseDSIP-LI after imipramine (hypothalamus, frontal cortex, cerebellum)
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
The antidepressant drugs imipramine and zimeldine, given orally twice daily for three weeks, reduced the concentrations of DSIP-LI in the hypothalamus, frontal cortex and cerebellum.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentration of delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat brain regions was determined by radioimmunoassay following treatment with various psychoactive drugs or adrenalectomy.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0252205201
02AnimalEndogenous levelAnimal study (in vivo)Other
In rats, three weeks of zimeldine reduced DSIP-like immunoreactivity in the hypothalamus, frontal cortex and cerebellum, somewhat less than imipramine.
In plain wordsIn rats, the antidepressant zimeldine lowered the body's own DSIP-like levels in three brain regions, a little less than imipramine.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseDSIP-LI after zimeldine (hypothalamus, frontal cortex, cerebellum)
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
The antidepressant drugs imipramine and zimeldine, given orally twice daily for three weeks, reduced the concentrations of DSIP-LI in the hypothalamus, frontal cortex and cerebellum. The effects of zimeldine were similar but somewhat less pronounced than those of imipramine.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentration of delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat brain regions was determined by radioimmunoassay following treatment with various psychoactive drugs or adrenalectomy.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0252205202
03AnimalEndogenous levelAnimal study (in vivo)Other
In rats, two weeks of haloperidol increased DSIP-like immunoreactivity in the hypothalamus.
In plain wordsIn rats, repeated haloperidol raised the body's own DSIP-like levels in the hypothalamus.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseDSIP-LI after repeated haloperidol (hypothalamus)
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
The neuroleptic drug haloperidol, given i.p. once daily for two weeks, increased the concentration of DSIP-LI in the hypothalamus
1 context sentence(design, population, supporting numbers)
Summary · context
The concentration of delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat brain regions was determined by radioimmunoassay following treatment with various psychoactive drugs or adrenalectomy.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0252205203
04AnimalEndogenous levelAnimal study (in vivo)Other
In rats, two weeks of haloperidol did not change DSIP-like immunoreactivity in the frontal cortex.
In plain wordsIn rats, repeated haloperidol did not change the body's own DSIP-like levels in the frontal cortex.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeDSIP-LI after repeated haloperidol (frontal cortex)
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
The neuroleptic drug haloperidol, given i.p. once daily for two weeks, increased the concentration of DSIP-LI in the hypothalamus, but not in the frontal cortex.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentration of delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat brain regions was determined by radioimmunoassay following treatment with various psychoactive drugs or adrenalectomy.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0252205204
05AnimalEndogenous levelAnimal study (in vivo)Other
In rats, a single dose of haloperidol did not affect DSIP-like immunoreactivity in the hypothalamus or frontal cortex.
In plain wordsIn rats, one dose of haloperidol did not change the body's own DSIP-like levels in two brain regions.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeDSIP-LI after single-dose haloperidol
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
A single dose of haloperidol did not affect the concentration of DSIP-LI in either region.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentration of delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat brain regions was determined by radioimmunoassay following treatment with various psychoactive drugs or adrenalectomy.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0252205205
06AnimalEndogenous levelAnimal study (in vivo)Other
In rats, pentobarbital raised DSIP-like immunoreactivity in the hypothalamus after a single dose.
In plain wordsIn rats, one dose of pentobarbital raised the body's own DSIP-like levels in the hypothalamus.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseDSIP-LI after single-dose pentobarbital (hypothalamus)
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Like haloperidol, pentobarbital elevated the concentration of DSIP-LI in the hypothalamus; however, this effect of the barbiturate was seen after single but not after repeated administration.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentration of delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat brain regions was determined by radioimmunoassay following treatment with various psychoactive drugs or adrenalectomy.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0252205206
07AnimalEndogenous levelAnimal study (in vivo)Other
In rats, repeated pentobarbital did not raise DSIP-like immunoreactivity in the hypothalamus.
In plain wordsIn rats, repeated pentobarbital did not raise the body's own DSIP-like levels in the hypothalamus.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeDSIP-LI after repeated pentobarbital (hypothalamus)
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Like haloperidol, pentobarbital elevated the concentration of DSIP-LI in the hypothalamus; however, this effect of the barbiturate was seen after single but not after repeated administration.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentration of delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat brain regions was determined by radioimmunoassay following treatment with various psychoactive drugs or adrenalectomy.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0252205207
08AnimalEndogenous levelAnimal study (in vivo)Other
In rats, cortical DSIP-like immunoreactivity was unaffected by single and repeated pentobarbital.
In plain wordsIn rats, pentobarbital did not change the body's own DSIP-like levels in the cortex.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeCortical DSIP-LI after pentobarbital
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Cortical concentrations of DSIP-LI were unaffected following both single and repeated pentobarbital administration.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentration of delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat brain regions was determined by radioimmunoassay following treatment with various psychoactive drugs or adrenalectomy.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0252205208
09AnimalEndogenous levelAnimal study (in vivo)Other
In rats, adrenalectomy increased DSIP-like immunoreactivity in the hypothalamus.
In plain wordsIn rats, removing the adrenal glands raised the body's own DSIP-like levels in the hypothalamus.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseDSIP-LI after adrenalectomy (hypothalamus)
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Finally, adrenalectomy increased the concentration of DSIP-LI in the hypothalamus
1 context sentence(design, population, supporting numbers)
Summary · context
The concentration of delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat brain regions was determined by radioimmunoassay following treatment with various psychoactive drugs or adrenalectomy.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0252205209
10AnimalEndogenous levelAnimal study (in vivo)Other
In rats, adrenalectomy did not change DSIP-like immunoreactivity in brain regions other than the hypothalamus.
In plain wordsIn rats, removing the adrenal glands did not change the body's own DSIP-like levels outside the hypothalamus.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeDSIP-LI after adrenalectomy (other brain regions)
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Finally, adrenalectomy increased the concentration of DSIP-LI in the hypothalamus, but not in the other brain regions.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentration of delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat brain regions was determined by radioimmunoassay following treatment with various psychoactive drugs or adrenalectomy.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0252205210

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

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