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Study · Not a test of the peptide alone · 1989

2 results

Effects of hypothyroidism, tri-iodothyronine and glucocorticoids on growth hormone responses to growth hormone-releasing hormone and His-D-Trp-Ala-Trp-D-Phe-Lys-NH2.

Edwards CA, Dieguez C, Scanlon MF

The Journal of endocrinology1 Apr 1989Cited by 12 (Europe PMC)

PMID2497223 (opens in a new tab)DOI10.1677/joe.0.1210031 (opens in a new tab)PepBankPUB-02497223
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In rats, hypothyroidism reduced the GH response to GHRP‑6 compared with euthyroidism.

    In plain wordsIn rats, hypothyroidism was linked to a lower GH response to GHRP‑6 than normal thyroid function.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH response in hypothyroidism
    Study

    ratn: not reported in source

    hypothyroid and euthyroid rats
    Comparator
    Euthyroid rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Peak GH
    508 micrograms/l
    euthyroid rats
    Peak GH
    203 micrograms/l
    hypothyroid rats

    Source sentences

    Summary
    Secretion of GH in response to GHRP-6 in vivo was reduced (P less than 0.01) in hypothyroid rats (peak GH responses, 508 +/- 177 micrograms/l in euthyroid rats vs 203 +/- 15 micrograms/l in hypothyroid rats).

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In rat pituitary cultures, hypothyroid-derived cells showed impaired responsiveness to GHRP‑6 compared with euthyroid-derived cells.

    In plain wordsIn cells from rats, hypothyroidism was linked to lower responsiveness to GHRP‑6 than normal thyroid function.

    Peptide
    GHRP-6
    Outcome
    DecreaseSomatotroph responsiveness
    Study

    ratn: not reported in source

    rat anterior pituitary monolayer cultures
    Comparator
    Euthyroid rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    In-vitro studies carried out using monolayer cultures of rat anterior pituitary cells derived from euthyroid and hypothyroid rats showed a marked impairment of somatotroph responsiveness to both GHRP-6 and somatostatin in cultures derived from hypothyroid rats.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:59 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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