The phosphorylated analogue of DSIP enhances slow wave sleep and paradoxical sleep in unrestrained rats.

Kimura M, Inoué S

Psychopharmacology1 Jan 1989Cited by 4 (Europe PMC)

PMID2496423DOI10.1007/bf00443409PepBankPUB-02496423

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

01AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In unrestrained rats, intracerebroventricular infusion of 0.5 nmol of the phosphorylated DSIP analogue P-DSIP increased slow wave sleep by 22%.
In plain wordsIn rats, an analogue of DSIP (P-DSIP) infused into the brain increased slow wave sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSlow wave sleep
Study
ratn: not reported in source
Outcome group
Sleep · Sleep
Measurements
Slow wave sleep increase
22%
0.5 nmol P-DSIP
Source sentences
Summary
Continued 10-h nocturnal intracerebroventricular infusion of 0.5 nmol P-DSIP, the phosphorylated analogue of delta-sleep-inducing peptide (DSIP), significantly increased slow wave sleep (22%)
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0249642301
02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In unrestrained rats, intracerebroventricular infusion of 0.5 nmol of the phosphorylated DSIP analogue P-DSIP increased paradoxical sleep by 81%.
In plain wordsIn rats, an analogue of DSIP (P-DSIP) infused into the brain increased paradoxical sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseParadoxical sleep
Study
ratn: not reported in source
Outcome group
Sleep · Sleep
Measurements
Paradoxical sleep increase
81%
0.5 nmol P-DSIP
Source sentences
Summary
Continued 10-h nocturnal intracerebroventricular infusion of 0.5 nmol P-DSIP, the phosphorylated analogue of delta-sleep-inducing peptide (DSIP), significantly increased slow wave sleep (22%) and paradoxical sleep (81%) in unrestrained rats.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0249642302
03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In rats, the P-DSIP increase in sleep amount was largely due to more sleep episodes.
In plain wordsIn rats, the DSIP analogue P-DSIP increased sleep mostly by increasing the number of sleep episodes.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseNumber of sleep episodes
Study
ratn: not reported in source
Outcome group
Sleep · Sleep
Source sentences
Summary
The increase in the amount of sleep was largely due to an increase in the number of sleep episodes.
1 context sentence(design, population, supporting numbers)
Summary · context
Continued 10-h nocturnal intracerebroventricular infusion of 0.5 nmol P-DSIP, the phosphorylated analogue of delta-sleep-inducing peptide (DSIP), significantly increased slow wave sleep (22%) and paradoxical sleep (81%) in unrestrained rats.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0249642303
04AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In rats, P-DSIP doses from 0.025 to 25 nmol, other than 0.5 nmol, were ineffective on sleep.
In plain wordsIn rats, larger and smaller doses of the DSIP analogue P-DSIP did not increase sleep.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeSleep at other P-DSIP doses
Study
ratn: not reported in source
Outcome group
Sleep · Sleep
Source sentences
Summary
Larger and smaller doses were ineffective in doses ranging from 0.025 to 25 nmol.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0249642304
05AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In rats, the sleep-promoting potency of P-DSIP was 5 times greater than that of DSIP in the same assay.
In plain wordsIn rats, the DSIP analogue P-DSIP promoted sleep 5 times more strongly than DSIP did.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSleep-promoting potency of P-DSIP compared with DSIP
Study
ratn: not reported in source
Comparator
DSIP
Outcome group
Sleep · Sleep
Measurements
Relative potency
5 fold
P-DSIP vs DSIP
Source sentences
Summary
The sleep-promoting potency of P-DSIP was 5 times greater than that of DSIP compared by the same assay.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0249642305

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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