Effect of vasoactive intestinal peptide on myocardial contractility and coronary blood flow in the dog: comparison with isoproterenol and forskolin.

Anderson FL, Kralios AC, Hershberger R, Bristow MR

Journal of cardiovascular pharmacology1 Sept 1988Cited by 20 (Europe PMC)

PMID2464111DOI10.1097/00005344-198809000-00016PepBankPUB-02464111

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In dogs, at maximal doses the increase in left ventricular dp/dt with forskolin was similar to that with VIP.
In plain wordsIn dogs, at the highest doses, forskolin and VIP raised heart pumping force by a similar amount.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeLeft ventricular dp/dt at maximal dose versus forskolin
Study
dogn = 10
Comparator
Forskolin
Outcome group
Heart function · Cardiovascular
Studied dose
2 x 10(-9) to 2 x 10(-7) mol · intracoronaryAs given in this study (dog).
Source sentences
Summary
In 10 additional dogs the effects of VIP and ISO were compared with forskolin given in doses ranging from 2 x 10(-9) to 2 x 10(-7) mol. At maximal doses (2 x 10(-7) mol) the increase in LV dp/dt was similar to VIP but significantly less than ISO, whereas the increase in CBF was similar to ISO but si…
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intracoronary injections of vasoactive intestinal peptide (VIP) on left ventricular (LV) dp/dt, coronary blood flow (CBF), and myocardial oxygen consumption (MVO2) were compared with isoproterenol (ISO) and forskolin in 18 dogs using a preparation in which cardiac output, mean systemi…
Report a problemFND-0246411106
02AnimalAnimal study (in vivo)Efficacy outcome
In dogs, at maximal doses the increase in coronary blood flow was significantly greater with VIP than with forskolin.
In plain wordsIn dogs, at the highest doses, VIP raised heart blood flow more than forskolin did.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseCoronary blood flow at maximal dose versus forskolin
Study
dogn = 10
Comparator
Forskolin
Outcome group
Heart function · Cardiovascular
Studied dose
2 x 10(-9) to 2 x 10(-7) mol · intracoronaryAs given in this study (dog).
Source sentences
Summary
In 10 additional dogs the effects of VIP and ISO were compared with forskolin given in doses ranging from 2 x 10(-9) to 2 x 10(-7) mol. At maximal doses (2 x 10(-7) mol) the increase in LV dp/dt was similar to VIP but significantly less than ISO, whereas the increase in CBF was similar to ISO but si…
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intracoronary injections of vasoactive intestinal peptide (VIP) on left ventricular (LV) dp/dt, coronary blood flow (CBF), and myocardial oxygen consumption (MVO2) were compared with isoproterenol (ISO) and forskolin in 18 dogs using a preparation in which cardiac output, mean systemi…
Report a problemFND-0246411107
03AnimalAnimal study (in vivo)Efficacy outcome
In dogs, intracoronary VIP significantly increased left ventricular dp/dt at doses of 6.6 x 10(-10) mol and above.
In plain wordsIn dogs, VIP injected into a heart artery increased the pumping force of the heart's left chamber.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseLeft ventricular dp/dt
Study
dogn = 8
Outcome group
Heart function · Cardiovascular
Studied dose
2 x 10(-12) to 2 x 10(-8) mol · intracoronaryAs given in this study (dog).
Source sentences
Summary
In eight dogs in which the effects of VIP and ISO were compared using doses ranging from 2 x 10(-12) to 2 x 10(-8) mol, both agents significantly increased LV dp/dt at doses greater than or equal to 6.6 x 10(-10) mol.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intracoronary injections of vasoactive intestinal peptide (VIP) on left ventricular (LV) dp/dt, coronary blood flow (CBF), and myocardial oxygen consumption (MVO2) were compared with isoproterenol (ISO) and forskolin in 18 dogs using a preparation in which cardiac output, mean systemi…
Report a problemFND-0246411101
04AnimalAnimal study (in vivo)Efficacy outcome
In dogs, at maximal doses the increase in left ventricular dp/dt was significantly smaller with VIP than with isoproterenol.
In plain wordsIn dogs, at the highest doses, VIP raised heart pumping force less than isoproterenol did.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseLeft ventricular dp/dt at maximal dose versus isoproterenol
Study
dogn = 8
Comparator
Isoproterenol
Outcome group
Heart function · Cardiovascular
Studied dose
2 x 10(-9) to 2 x 10(-8) mol · intracoronaryAs given in this study (dog).
Source sentences
Summary
At maximal doses (2 x 10(-9) to 2 x 10(-8) mol) the effect of ISO was significantly greater than VIP.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intracoronary injections of vasoactive intestinal peptide (VIP) on left ventricular (LV) dp/dt, coronary blood flow (CBF), and myocardial oxygen consumption (MVO2) were compared with isoproterenol (ISO) and forskolin in 18 dogs using a preparation in which cardiac output, mean systemi…
Report a problemFND-0246411102
05AnimalAnimal study (in vivo)Efficacy outcome
In dogs, intracoronary VIP significantly increased coronary blood flow at all doses.
In plain wordsIn dogs, VIP injected into a heart artery increased blood flow in the heart's vessels at every dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseCoronary blood flow
Study
dogn = 8
Outcome group
Heart function · Cardiovascular
Studied dose
2 x 10(-12) to 2 x 10(-8) mol · intracoronaryAs given in this study (dog).
Source sentences
Summary
Both VIP and ISO significantly increased CBF at all doses, but at maximal doses the effect of VIP on CBF was significantly greater than ISO.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intracoronary injections of vasoactive intestinal peptide (VIP) on left ventricular (LV) dp/dt, coronary blood flow (CBF), and myocardial oxygen consumption (MVO2) were compared with isoproterenol (ISO) and forskolin in 18 dogs using a preparation in which cardiac output, mean systemi…
Report a problemFND-0246411103
06AnimalAnimal study (in vivo)Efficacy outcome
In dogs, at maximal doses the effect of VIP on coronary blood flow was significantly greater than that of isoproterenol.
In plain wordsIn dogs, at the highest doses, VIP raised heart blood flow more than isoproterenol did.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseCoronary blood flow at maximal dose versus isoproterenol
Study
dogn = 8
Comparator
Isoproterenol
Outcome group
Heart function · Cardiovascular
Studied dose
2 x 10(-9) to 2 x 10(-8) mol · intracoronaryAs given in this study (dog).
Source sentences
Summary
but at maximal doses the effect of VIP on CBF was significantly greater than ISO.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intracoronary injections of vasoactive intestinal peptide (VIP) on left ventricular (LV) dp/dt, coronary blood flow (CBF), and myocardial oxygen consumption (MVO2) were compared with isoproterenol (ISO) and forskolin in 18 dogs using a preparation in which cardiac output, mean systemi…
Report a problemFND-0246411104
07AnimalAnimal study (in vivo)Efficacy outcome
In dogs, the increase in coronary blood flow relative to the increase in myocardial oxygen consumption, an index of direct coronary vasodilation, was significantly greater for VIP than isoproterenol.
In plain wordsIn dogs, VIP widened heart vessels more directly than isoproterenol did, relative to the oxygen use of the heart muscle.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseCoronary blood flow relative to myocardial oxygen consumption versus isoproterenol
Study
dogn = 8
Comparator
Isoproterenol
Outcome group
Heart function · Cardiovascular
Studied dose
2 x 10(-12) to 2 x 10(-8) mol · intracoronaryAs given in this study (dog).
Source sentences
Summary
The increase in CBF relative to the increase in MVO2, an index of direct coronary vasodilation, was significantly greater for VIP compared with ISO.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intracoronary injections of vasoactive intestinal peptide (VIP) on left ventricular (LV) dp/dt, coronary blood flow (CBF), and myocardial oxygen consumption (MVO2) were compared with isoproterenol (ISO) and forskolin in 18 dogs using a preparation in which cardiac output, mean systemi…
Report a problemFND-0246411105

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Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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