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Study · In vitro (cell-free) · rat · 1988

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The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme 'endopeptidase-2' and by rat microvillar membranes.

Stephenson SL, Kenny AJ

The Biochemical journal1 Oct 1988Cited by 41 (Europe PMC)

PMID2461706 (opens in a new tab)PMCIDPMC1135188 (opens in a new tab)DOI10.1042/bj2550045 (opens in a new tab)PepBankPUB-02461706
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Activity measurement

    In lab tests, rat kidney endopeptidase-2 did not hydrolyse oxytocin.

    In plain wordsIn lab tests, a rat kidney enzyme did not break down oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeHydrolysis by endopeptidase-2
    Study

    ratn: not reported in source

    Rat kidney endopeptidase-2 (purified enzyme and microvillar membranes)
    Outcome group
    Peptide structure and chemistry · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin and [Arg8]vasopressin were not hydrolysed
    1 context sentence
    Summary · context
    Endopeptidase-2, the second endopeptidase in rat kidney brush border [Kenny & Ingram (1987) Biochem. J. 245, 515-524] has been further characterized in regard to its specificity and its contribution to the hydrolysis of peptides by microvillar membrane preparations.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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