Comparison of DSIP- (delta sleep-inducing peptide) and P-DSIP-like (phosphorylated) immunoreactivity in cerebrospinal fluid of patients with senile dementia of Alzheimer type, multi-infarct syndrome, communicating hydrocephalus and Parkinson's disease.

Ernst A, Cramer H, Strubel D, Kuntzmann F, Schoenenberger GA

Journal of neurology1 Oct 1987Cited by 10 (Europe PMC)

PMID2448424DOI10.1007/bf00314191PepBankPUB-02448424

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Natural levels measured11

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In control patients, natural DSIP-like immunoreactivity in cerebrospinal fluid was significantly higher in elderly than in middle-aged controls.
In plain wordsIn control patients, the body's own DSIP-like material in spinal fluid was higher in elderly than in middle-aged people.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseCSF DSIP-LI in elderly vs middle-aged controls
Study
n: not reported in source
Comparator
Middle-aged controls (C2)
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Mean DSIP-LI and P-DSIP-LI concentrations were found to be significantly higher in the elderly control group (C1, mean age 83 +/- 5 years) than in the middle-aged control group (C2, mean age 40 +/- 16 years).
1 context sentence(design, population, supporting numbers)
Summary · context
The concentrations of delta sleep-inducing peptide (DSIP)-like (DSIP-LI) and P-DSIP-like (phosphorylated, Ser7) immunoreactivity (P-DSIP-LI) were measured by specific radioimmunoassay in the cerebrospinal fluid (CSF)
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0244842401
02HumanEndogenous levelObservational studyOther
In control patients, natural phosphorylated DSIP-like immunoreactivity in cerebrospinal fluid was significantly higher in elderly than in middle-aged controls.
In plain wordsIn control patients, the body's own phosphorylated DSIP-like material in spinal fluid was higher in elderly than in middle-aged people.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseCSF P-DSIP-LI in elderly vs middle-aged controls
Study
n: not reported in source
Comparator
Middle-aged controls (C2)
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Mean DSIP-LI and P-DSIP-LI concentrations were found to be significantly higher in the elderly control group (C1, mean age 83 +/- 5 years) than in the middle-aged control group (C2, mean age 40 +/- 16 years).
1 context sentence(design, population, supporting numbers)
Summary · context
The concentrations of delta sleep-inducing peptide (DSIP)-like (DSIP-LI) and P-DSIP-like (phosphorylated, Ser7) immunoreactivity (P-DSIP-LI) were measured by specific radioimmunoassay in the cerebrospinal fluid (CSF)
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0244842402
03HumanEndogenous levelObservational studyOther
In control patients, natural DSIP-like immunoreactivity in cerebrospinal fluid correlated positively with age.
In plain wordsIn control patients, the body's own DSIP-like material in spinal fluid was linked to older age.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseCorrelation of CSF DSIP-LI with age in controls
Study
n: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
DSIP-LI and P-DSIP-LI were positively correlated with age in both control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentrations of delta sleep-inducing peptide (DSIP)-like (DSIP-LI) and P-DSIP-like (phosphorylated, Ser7) immunoreactivity (P-DSIP-LI) were measured by specific radioimmunoassay in the cerebrospinal fluid (CSF)
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0244842403
04HumanEndogenous levelObservational studyOther
In control patients, natural phosphorylated DSIP-like immunoreactivity in cerebrospinal fluid correlated positively with age.
In plain wordsIn control patients, the body's own phosphorylated DSIP-like material in spinal fluid was linked to older age.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseCorrelation of CSF P-DSIP-LI with age in controls
Study
n: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
DSIP-LI and P-DSIP-LI were positively correlated with age in both control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentrations of delta sleep-inducing peptide (DSIP)-like (DSIP-LI) and P-DSIP-like (phosphorylated, Ser7) immunoreactivity (P-DSIP-LI) were measured by specific radioimmunoassay in the cerebrospinal fluid (CSF)
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0244842404
05HumanEndogenous levelObservational studyOther
In patients with middle-stage senile dementia of the Alzheimer type, natural DSIP-like immunoreactivity in cerebrospinal fluid was significantly lower than in age-matched controls.
In plain wordsIn patients with middle-stage Alzheimer-type dementia, the body's own DSIP-like material in spinal fluid was lower than in age-matched controls.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseCSF DSIP-LI in middle-stage Alzheimer-type dementia
Study
n: not reported in source
Comparator
Age-matched controls (C1)
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Significant decreases of DSIP-LI compared with age-matched controls (C1) were observed for S2, S3, MD, PD, VD and H.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentrations of delta sleep-inducing peptide (DSIP)-like (DSIP-LI) and P-DSIP-like (phosphorylated, Ser7) immunoreactivity (P-DSIP-LI) were measured by specific radioimmunoassay in the cerebrospinal fluid (CSF)
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0244842405
06HumanEndogenous levelObservational studyOther
In patients with late-stage senile dementia of the Alzheimer type, natural DSIP-like immunoreactivity in cerebrospinal fluid was significantly lower than in age-matched controls.
In plain wordsIn patients with late-stage Alzheimer-type dementia, the body's own DSIP-like material in spinal fluid was lower than in age-matched controls.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseCSF DSIP-LI in late-stage Alzheimer-type dementia
Study
n: not reported in source
Comparator
Age-matched controls (C1)
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Significant decreases of DSIP-LI compared with age-matched controls (C1) were observed for S2, S3, MD, PD, VD and H.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentrations of delta sleep-inducing peptide (DSIP)-like (DSIP-LI) and P-DSIP-like (phosphorylated, Ser7) immunoreactivity (P-DSIP-LI) were measured by specific radioimmunoassay in the cerebrospinal fluid (CSF)
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0244842406
07HumanEndogenous levelObservational studyOther
In patients with multi-infarct dementia, natural DSIP-like immunoreactivity in cerebrospinal fluid was significantly lower than in age-matched controls.
In plain wordsIn patients with multi-infarct dementia, the body's own DSIP-like material in spinal fluid was lower than in age-matched controls.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseCSF DSIP-LI in multi-infarct dementia
Study
n: not reported in source
Comparator
Age-matched controls (C1)
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Significant decreases of DSIP-LI compared with age-matched controls (C1) were observed for S2, S3, MD, PD, VD and H.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentrations of delta sleep-inducing peptide (DSIP)-like (DSIP-LI) and P-DSIP-like (phosphorylated, Ser7) immunoreactivity (P-DSIP-LI) were measured by specific radioimmunoassay in the cerebrospinal fluid (CSF)
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0244842407
08HumanEndogenous levelObservational studyOther
In patients with Parkinson's disease, natural DSIP-like immunoreactivity in cerebrospinal fluid was significantly lower than in age-matched controls.
In plain wordsIn patients with Parkinson's disease, the body's own DSIP-like material in spinal fluid was lower than in age-matched controls.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseCSF DSIP-LI in Parkinson's disease
Study
n: not reported in source
Comparator
Age-matched controls (C1)
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Significant decreases of DSIP-LI compared with age-matched controls (C1) were observed for S2, S3, MD, PD, VD and H.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentrations of delta sleep-inducing peptide (DSIP)-like (DSIP-LI) and P-DSIP-like (phosphorylated, Ser7) immunoreactivity (P-DSIP-LI) were measured by specific radioimmunoassay in the cerebrospinal fluid (CSF)
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0244842408
09HumanEndogenous levelObservational studyOther
In patients with vascular disease, natural DSIP-like immunoreactivity in cerebrospinal fluid was significantly lower than in age-matched controls.
In plain wordsIn patients with vascular disease, the body's own DSIP-like material in spinal fluid was lower than in age-matched controls.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseCSF DSIP-LI in vascular disease
Study
n: not reported in source
Comparator
Age-matched controls (C1)
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Significant decreases of DSIP-LI compared with age-matched controls (C1) were observed for S2, S3, MD, PD, VD and H.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentrations of delta sleep-inducing peptide (DSIP)-like (DSIP-LI) and P-DSIP-like (phosphorylated, Ser7) immunoreactivity (P-DSIP-LI) were measured by specific radioimmunoassay in the cerebrospinal fluid (CSF)
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0244842409
10HumanEndogenous levelObservational studyOther
In patients with communicating hydrocephalus, natural DSIP-like immunoreactivity in cerebrospinal fluid was significantly lower than in age-matched controls.
In plain wordsIn patients with communicating hydrocephalus, the body's own DSIP-like material in spinal fluid was lower than in age-matched controls.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseCSF DSIP-LI in communicating hydrocephalus
Study
n: not reported in source
Comparator
Age-matched controls (C1)
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Significant decreases of DSIP-LI compared with age-matched controls (C1) were observed for S2, S3, MD, PD, VD and H.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentrations of delta sleep-inducing peptide (DSIP)-like (DSIP-LI) and P-DSIP-like (phosphorylated, Ser7) immunoreactivity (P-DSIP-LI) were measured by specific radioimmunoassay in the cerebrospinal fluid (CSF)
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0244842410
11HumanEndogenous levelObservational studyOther
In patients with the studied dementias and brain diseases, natural phosphorylated DSIP-like immunoreactivity in cerebrospinal fluid showed no significant differences corresponding to pathology.
In plain wordsIn patients with the studied brain diseases, the body's own phosphorylated DSIP-like material in spinal fluid did not differ with disease.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeCSF P-DSIP-LI across diseases
Study
n: not reported in source
Comparator
Age-matched controls (C1)
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
In contrast, no significant differences corresponding to pathology were found for P-DSIP-LI.
1 context sentence(design, population, supporting numbers)
Summary · context
The concentrations of delta sleep-inducing peptide (DSIP)-like (DSIP-LI) and P-DSIP-like (phosphorylated, Ser7) immunoreactivity (P-DSIP-LI) were measured by specific radioimmunoassay in the cerebrospinal fluid (CSF)
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0244842411

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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