Localization of thymosin alpha 1 production to thymus medullary epithelial cells by use of monoclonal antibodies.

Oates KK, Naylor PH, Goldstein AL

Hybridoma1 Feb 1987Cited by 10 (Europe PMC)

PMID2445653DOI10.1089/hyb.1987.6.47PepBankPUB-02445653

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01LabEndogenous levelEx vivo tissueOther
In perfused rat thymus, indirect immunofluorescence with anti-thymosin alpha‑1 monoclonal antibodies found thymosin alpha‑1 containing cells mainly in the thymic medulla.
In plain wordsIn rats, the body's own thymosin alpha‑1 was found mainly in cells of the inner part of the thymus.
Peptide
Thymosin alpha-1
Outcome
Not applicableThymosin alpha 1 containing cells in rat thymus
Study
ratn: not reported in source
perfused rat thymus
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Thymosin alpha 1 containing cells were found primarily in the thymic medulla, confirming previous studies using the heterologous antisera.
1 context sentence(design, population, supporting numbers)
Summary · context
The anti-thymosin alpha 1 monoclonal antibodies were then used for indirect immune fluorescence studies of perfused rat thymus.
This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0244565301

Studies that did not test the peptide alone1

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

02LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Activity measurement
Eight anti-thymosin alpha‑1 monoclonal antibodies were produced, and the studies showed their specificity for immunochemical localization of thymosin alpha‑1.
In plain wordsIn lab tests, new antibodies were made that specifically detect thymosin alpha‑1 and can be used to find it in tissue.
Peptide
Thymosin alpha-1
Outcome
Not applicableSpecificity of anti-thymosin alpha 1 monoclonal antibodies
Study
mousen: not reported in source
monoclonal antibodies from immunized BALB/c mice, ELISA and RIA
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
In the studies, reported here, eight anti-thymosin alpha 1 monoclonal antibodies (MAbs) were produced by somatic cell fusion between spleen cells from immunized BALB/c mice and P3x64 Ag8.653 myeloma cells.
2 context sentences(design, population, supporting numbers)
Summary · context
The MAbs were screened for anti-thymosin alpha 1 specificity in a solid phase ELISA and a liquid phase RIA.
Summary · context
These studies demonstrated the specificity of the anti-thymosin alpha 1 monoclonal antibodies for immunochemical studies of intra- and extra-thymic localization of thymosin alpha 1.
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.
Report a problemFND-0244565302

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC