A novel vasoactive intestinal peptide (VIP) from elasmobranch intestine has full affinity for mammalian pancreatic VIP receptors.

Dimaline R, Young J, Thwaites DT, Lee CM, Shuttleworth TJ, Thorndyke MC

Biochimica et biophysica acta1 Aug 1987Cited by 21 (Europe PMC)

PMID2441759DOI10.1016/0167-4889(87)90160-1PepBankPUB-02441759

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
Dogfish VIP was equipotent with porcine VIP in inhibiting binding of labelled VIP to guinea pig dispersed pancreatic acini.
In plain wordsIn lab tests on guinea pig pancreas cells, dogfish VIP blocked VIP binding as strongly as pig VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeInhibition of 125I-VIP binding to pancreatic acini
Study
guinea pign: not reported in source
Dispersed pancreatic acini
Comparator
Porcine VIP
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Dogfish VIP was equipotent with its porcine counterpart in inhibiting binding of 125I-labelled VIP to guinea pig dispersed pancreatic acini, and in stimulating amylase secretion by the same preparation.
Report a problemFND-0244175903
02LabEx vivo tissueActivity measurement
Dogfish VIP was equipotent with porcine VIP in stimulating amylase secretion by guinea pig dispersed pancreatic acini.
In plain wordsIn lab tests on guinea pig pancreas cells, dogfish VIP triggered amylase release as strongly as pig VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeStimulation of amylase secretion from pancreatic acini
Study
guinea pign: not reported in source
Dispersed pancreatic acini
Comparator
Porcine VIP
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Dogfish VIP was equipotent with its porcine counterpart in inhibiting binding of 125I-labelled VIP to guinea pig dispersed pancreatic acini, and in stimulating amylase secretion by the same preparation.
Report a problemFND-0244175904

Studies that did not test the peptide alone2

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

03LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cell-free)Other
A VIP-like peptide from dogfish intestine was sequenced and its C-terminus was found to be amidated.
In plain wordsIn lab tests, the structure of a VIP-like peptide from dogfish intestine was determined.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableAmino acid sequence and C-terminal amidation of dogfish VIP
Study
dogfishn: not reported in source
Peptide isolated from dogfish intestine
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Microsequence analysis gave the structure His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Ser-Arg-Ile-Arg-Lys-Gln-Met-Ala-Val-Lys - Lys-Tyr-Ile-Asn-Ser-Leu-Leu-Ala-NH2. C-terminal amidation was determined by HPLC analysis of phenylthiocarbamyl amino acid derivatives after carboxypeptidase Y digestion.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0244175901
04LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cell-free)Other
Dogfish VIP differs at five positions from the porcine octacosapeptide.
In plain wordsIn lab tests, dogfish VIP differed from pig VIP at five positions in its sequence.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableSequence difference between dogfish VIP and porcine VIP
Study
dogfishn: not reported in source
Peptide isolated from dogfish intestine
Comparator
Porcine octacosapeptide
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
The peptide differs at five positions from the porcine octacosapeptide.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0244175902

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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