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Study · Animal study (in vivo) · rat · 1987

5 results

[Comparison of the effects of DSIP and SP 1-11 on stress-induced chronic sleep disorders in rats].

Wachtel E, Koplik E, Kolometsewa IA, Balzer HU, Hecht K, Oehme P, Ivanow VT

Die Pharmazie1 Mar 1987Cited by 2 (Europe PMC)

PMID2440061 (opens in a new tab)PepBankPUB-02440061
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In chronically stressed rats with hyposomnia, DSIP was less potent than substance P 1-11 in normalizing sleep deprivation.

    In plain wordsIn rats with stress-induced poor sleep, DSIP was less potent than substance P 1-11 at normalizing sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseNormalization of sleep deprivation in rats with stress-induced hyposomnia
    Study

    ratn: not reported in source

    Comparator
    Substance P 1-11 (SP1-11)
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results indicated that SP1-11 is more potent than DSIP in rats with stress-induced hyposomnia.
    1 context sentence
    Summary · context
    In the present paper the effects of substance P (SP1-11, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) and delta sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) to normalize the deprivation of sleep in chronically stressed rats with hyposomnia were investigated.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In chronically stressed rats with hyposomnia, the abstract reports different effects on the duration of sleep, without direction or size.

    In plain wordsIn rats with stress-induced poor sleep, the abstract reports different effects on sleep duration but gives no direction or size.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedDuration of sleep
    Study

    ratn: not reported in source

    Comparator
    Substance P 1-11 (SP1-11)
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Different effects were found in the duration of sleep, the percentage of sleep phases compared to wake phases, the rhythm of sleep phases and the time periods of sleep-cycles.
    1 context sentence
    Summary · context
    In the present paper the effects of substance P (SP1-11, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) and delta sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) to normalize the deprivation of sleep in chronically stressed rats with hyposomnia were investigated.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In chronically stressed rats with hyposomnia, the abstract reports different effects on the percentage of sleep phases compared with wake phases, without direction or size.

    In plain wordsIn rats with stress-induced poor sleep, the abstract reports different effects on sleep versus wake time but gives no direction or size.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedPercentage of sleep phases compared to wake phases
    Study

    ratn: not reported in source

    Comparator
    Substance P 1-11 (SP1-11)
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Different effects were found in the duration of sleep, the percentage of sleep phases compared to wake phases, the rhythm of sleep phases and the time periods of sleep-cycles.
    1 context sentence
    Summary · context
    In the present paper the effects of substance P (SP1-11, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) and delta sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) to normalize the deprivation of sleep in chronically stressed rats with hyposomnia were investigated.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In chronically stressed rats with hyposomnia, the abstract reports different effects on the rhythm of sleep phases, without direction or size.

    In plain wordsIn rats with stress-induced poor sleep, the abstract reports different effects on the rhythm of sleep phases but gives no direction or size.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedRhythm of sleep phases
    Study

    ratn: not reported in source

    Comparator
    Substance P 1-11 (SP1-11)
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Different effects were found in the duration of sleep, the percentage of sleep phases compared to wake phases, the rhythm of sleep phases and the time periods of sleep-cycles.
    1 context sentence
    Summary · context
    In the present paper the effects of substance P (SP1-11, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) and delta sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) to normalize the deprivation of sleep in chronically stressed rats with hyposomnia were investigated.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In chronically stressed rats with hyposomnia, the abstract reports different effects on the time periods of sleep cycles, without direction or size.

    In plain wordsIn rats with stress-induced poor sleep, the abstract reports different effects on the length of sleep cycles but gives no direction or size.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedTime periods of sleep cycles
    Study

    ratn: not reported in source

    Comparator
    Substance P 1-11 (SP1-11)
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Different effects were found in the duration of sleep, the percentage of sleep phases compared to wake phases, the rhythm of sleep phases and the time periods of sleep-cycles.
    1 context sentence
    Summary · context
    In the present paper the effects of substance P (SP1-11, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) and delta sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) to normalize the deprivation of sleep in chronically stressed rats with hyposomnia were investigated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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