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Study · Animal study (in vivo) · mouse · 1987

2 results

Partial protection from the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by Pro-Leu-Gly-NH2(PLG; MIF-1).

Sheng JG, Xu DL, Yu HZ, Xu XR, Tang QM

Life sciences1 May 1987Cited by 10 (Europe PMC)

PMID2437428 (opens in a new tab)DOI10.1016/0024-3205(87)90291-8 (opens in a new tab)PepBankPUB-02437428
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In MPTP-treated mice, PLG pretreatment preserved higher mean striatal dopamine levels than MPTP alone despite a reduction.

    In plain wordsIn mice given MPTP, PLG pretreatment preserved higher dopamine levels than MPTP alone despite a decrease.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseStriatal dopamine
    Study

    mousen: not reported in source

    MPTP-treated C57-BL black mice
    Comparator
    MPTP alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the mice pretreated with PLG, although the striatal dopamine level was also reduced, mean dopamine and serotonin levels were significantly higher than in mice given MPTP alone.
    1 context sentence
    Summary · context
    MPTP was injected in C57-BL black mice, 36 mg per kg for 7 days, which resulted in permanent reduction of dopamine and serotonin levels in the striatum.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In MPTP-treated mice, PLG pretreatment preserved higher mean striatal serotonin levels than MPTP alone.

    In plain wordsIn mice given MPTP, PLG pretreatment preserved higher serotonin levels than MPTP alone.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseStriatal serotonin
    Study

    mousen: not reported in source

    MPTP-treated C57-BL black mice
    Comparator
    MPTP alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the mice pretreated with PLG, although the striatal dopamine level was also reduced, mean dopamine and serotonin levels were significantly higher than in mice given MPTP alone.
    1 context sentence
    Summary · context
    MPTP was injected in C57-BL black mice, 36 mg per kg for 7 days, which resulted in permanent reduction of dopamine and serotonin levels in the striatum.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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