Skip to content

Study · Not a test of the peptide alone · 1987

2 results

Effect of diphenylhydantoin on drug and calcium induced contractions of isolated rat uterus: a comparative study with nifedipine.

Calixto JB

General pharmacology1 Jan 1987Cited by 3 (Europe PMC)

PMID2436973 (opens in a new tab)DOI10.1016/0306-3623(87)90005-x (opens in a new tab)PepBankPUB-02436973
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In isolated rat uterus, diphenylhydantoin and nifedipine inhibited oxytocin-induced sustained contractions in a concentration-dependent fashion.

    In plain wordsIn lab tests on rat uterus, the drugs diphenylhydantoin and nifedipine reduced contractions caused by oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-induced sustained uterine contractions with DPH or nifedipine
    Study

    Ratn: not reported in source

    Isolated rat uterus
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    The sustained contractions induced by K+, acetylcholine (ACh) and oxytocin (Ot) were inhibited in a concentration-dependent fashion by diphenylhydantoin (DPH) and nifedipine (NIF) in the following order of sensitivity: K+ greater than ACh greater than Ot.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In isolated rat uterus, previous incubation with diphenylhydantoin and nifedipine produced a non-competitive antagonism towards oxytocin-induced contractions.

    In plain wordsIn lab tests on rat uterus, diphenylhydantoin and nifedipine blocked oxytocin-caused contractions in a non-competitive way.

    Peptide
    Oxytocin
    Outcome
    DecreaseType of antagonism of oxytocin-induced contractions by DPH or nifedipine
    Study

    Ratn: not reported in source

    Isolated rat uterus
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    Previous incubation of DPH and NIF produced a non-competitive antagonism towards ACh and Ot-induced contractions.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.