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Study · Not a test of the peptide alone · 1986

4 results

Antigenic specificity of a rabbit antiserum raised against the 15-28 segment of thymosin alpha 1.

Ishimura K, Incefy GS, Wang JG, Komiyama T, Heimer EP, Felix AM, Unson CG, Khan SA, Erickson BW

Molecular immunology1 Jul 1986Cited by 2 (Europe PMC)

PMID2432409 (opens in a new tab)DOI10.1016/0161-5890(86)90080-5 (opens in a new tab)PepBankPUB-02432409
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Other

    A rabbit antiserum raised against thymosin alpha‑1-(15-28) bound the segments Ac-(1-28), (15-28), (20-28) and (21-28) with nearly equal efficiency but did not bind Ac-(1-10), (11-20), (19-24) or (22-28).

    In plain wordsIn lab tests, an antiserum recognized the end of the thymosin alpha‑1 peptide but not its other segments.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAntiserum binding of thymosin alpha 1 segments
    Study

    n: not reported in source

    Radioimmunoassay with rabbit antiserum
    Outcome group
    Analytical methods and detection · Pharmacology

    Source sentences

    Summary
    The antiserum bound segments Ac-(1-28), (15-28), (20-28) and (21-28) with nearly equal efficiency but failed to bind segments Ac-(1-10), (11-20), (19-24) and (22-28).
    1 context sentence
    Summary · context
    The detailed antigenic specificity of this antiserum was determined by measuring the ability of synthetic segments and analogues of thymosin alpha 1 and related peptides to compete with radioiodinated Ac-Tyr-thymosin alpha 1-(15-28) in this radioimmunoassay.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Other

    The antiserum bound prothymosin alpha and thymosin alpha 11 with 0.9% and 0.2%, respectively, of its efficiency for thymosin alpha‑1.

    In plain wordsIn lab tests, the antiserum bound related peptides far less well than thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAntiserum cross-reactivity with prothymosin alpha and thymosin alpha 11
    Study

    n: not reported in source

    Radioimmunoassay with rabbit antiserum
    Outcome group
    Analytical methods and detection · Pharmacology

    Measurements

    Relative binding efficiency, prothymosin alpha
    0.9%
    versus thymosin alpha 1
    Relative binding efficiency, thymosin alpha 11
    0.2%
    versus thymosin alpha 1

    Source sentences

    Summary
    The antiserum bound to prothymosin alpha and thymosin alpha 11, which lack the alpha-carboxylate group of Asn-28, with 0.9 and 0.2%, respectively, of the efficiency of thymosin alpha 1.
    1 context sentence
    Summary · context
    The detailed antigenic specificity of this antiserum was determined by measuring the ability of synthetic segments and analogues of thymosin alpha 1 and related peptides to compete with radioiodinated Ac-Tyr-thymosin alpha 1-(15-28) in this radioimmunoassay.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 03LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Other

    The antiserum bound nonspecifically to parathymosin alpha, which contains an internal segment similar to the thymosin alpha‑1 C-terminus.

    In plain wordsIn lab tests, the antiserum also stuck to parathymosin alpha, which shares a similar stretch.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAntiserum binding to parathymosin alpha
    Study

    n: not reported in source

    Radioimmunoassay with rabbit antiserum
    Outcome group
    Analytical methods and detection · Pharmacology

    Source sentences

    Summary
    But it bound nonspecifically to parathymosin alpha, which contains the internal segment . . . -Glu-Val-Val-Glu-Glu-Glu-Glu-Asn- . . . .
    1 context sentence
    Summary · context
    The detailed antigenic specificity of this antiserum was determined by measuring the ability of synthetic segments and analogues of thymosin alpha 1 and related peptides to compete with radioiodinated Ac-Tyr-thymosin alpha 1-(15-28) in this radioimmunoassay.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  4. 04LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Other

    In a radioimmunoassay with a rabbit antiserum, the immunoreactivity of thymosin alpha‑1 segment (21-28) was nearly abolished when the carboxylate groups of Glu-21, Glu-27 and Asn-28 were omitted separately.

    In plain wordsIn lab tests, the antiserum almost stopped recognizing the end segment of thymosin alpha‑1 when one of three acid groups was left out.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseEffect of carboxylate group removal on antiserum binding of segment 21-28
    Study

    n: not reported in source

    Radioimmunoassay with rabbit antiserum
    Outcome group
    Analytical methods and detection · Pharmacology

    Source sentences

    Summary
    Immunoreactivity of (21-28) was nearly abolished when the carboxylate groups of Glu-21, Glu-27 and Asn-28 were omitted separately.
    1 context sentence
    Summary · context
    The detailed antigenic specificity of this antiserum was determined by measuring the ability of synthetic segments and analogues of thymosin alpha 1 and related peptides to compete with radioiodinated Ac-Tyr-thymosin alpha 1-(15-28) in this radioimmunoassay.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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