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Study · Measured the body's own peptide · 1985

8 results

Vasoactive intestinal polypeptide and substance P in primary afferent pathways to the sacral spinal cord of the cat.

Kawatani M, Erdman SL, de Groat WC

The Journal of comparative neurology1 Nov 1985Cited by 63 (Europe PMC)

PMID2418069 (opens in a new tab)DOI10.1002/cne.902410307 (opens in a new tab)PepBankPUB-02418069
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Natural levels measured8

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the cat spinal cord, VIP immunoreactivity was most prominent in the sacral segments, in Lissauer's tract and lamina I of the dorsal horn.

    In plain wordsIn cats, the body's own VIP was most prominent in the lower (sacral) spinal cord, in a pain-related pathway.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP-IR distribution in sacral cord
    Study

    catn: not reported in source

    spinal cord, immunohistochemistry
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    An analysis of vasoactive intestinal polypeptide immunoreactivity (VIP-IR) and substance P-IR in the cat spinal cord has revealed marked differences in the distribution of the two peptides. While substance P-IR was located at all levels of the cord, VIP-IR was most prominent in the sacral segments i…

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the cat sacral cord, VIP immunoreactivity was also present in laminae V, VII and X, the dorsal commissure, the sacral parasympathetic nucleus and, in a few animals, Onuf's nucleus.

    In plain wordsIn cats, the body's own VIP was also found in several other areas of the lower spinal cord.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP-IR in other sacral cord areas
    Study

    catn: not reported in source

    spinal cord, immunohistochemistry
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    VIP-IR was also present in the sacral cord in (1) laminae V, VII, and X, (2) a thin band on the medial side of the dorsal horn, (3) the dorsal commissure, (4) the lateral band of the sacral parasympathetic nucleus, and (5) in a few animals in Onuf's nucleus.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In other segments of the cat spinal cord, VIP immunoreactivity was much less prominent but present in Lissauer's tract and laminae I, II and X.

    In plain wordsIn cats, the body's own VIP was much less prominent in other spinal cord segments.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP-IR in other spinal segments
    Study

    catn: not reported in source

    spinal cord, immunohistochemistry
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    In other segments of the spinal cord VIP-IR was much less prominent but was present in Lissauer's tract and laminae I, II, and X.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In ventrolateral lamina I of the cat sacral cord, VIP immunoreactivity showed a periodic pattern along the rostrocaudal axis, with axon bundles about 210 microns apart.

    In plain wordsIn cats, the body's own VIP showed a regular repeating pattern along the lower spinal cord.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicablePeriodic pattern of VIP-IR axons in lamina I
    Study

    catn: not reported in source

    spinal cord, immunohistochemistry
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Measurements

    Bundle spacing
    ≈ 210 micron
    sacral spinal cord

    Source sentences

    Summary
    In ventrolateral lamina I of the sacral spinal cord both VIP-IR and substance P-IR exhibited a distinctive periodic pattern in the rostrocaudal axis. The peptides were associated with bundles of dorsoventrally oriented axons and varicosities spaced at approximately 210-micron intervals center to cen…

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  5. 05AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the cat sacral cord, the most prominent bundles of VIP axons passed ventrally from lateral laminae V and VII to enter lamina X and the ventral dorsal gray commissure.

    In plain wordsIn cats, bundles of nerve fibres with the body's own VIP ran towards the centre of the lower spinal cord.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVentral course of VIP axons
    Study

    catn: not reported in source

    spinal cord, immunohistochemistry
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    The most prominent bundles of VIP axons passed ventrally from lateral laminae V and VII to enter lamina X and the ventral part of the dorsal gray commissure.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  6. 06AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the cat spinal cord, rostrocaudal VIP axons were present in Lissauer's tract, dorsolateral lamina I, the lateral funiculus and the ependymal layer of the central canal.

    In plain wordsIn cats, nerve fibres with the body's own VIP ran along the length of the spinal cord in several areas.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableRostrocaudal VIP axons
    Study

    catn: not reported in source

    spinal cord, immunohistochemistry
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    Rostrocaudal VIP axons were present not only in Lissauer's tract but also in dorsolateral lamina I, in the lateral funiculus and in the ependymal cell layer of the central canal.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  7. 07AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In cats, unilateral transection of the sacral dorsal roots markedly reduced the density of VIP axons and terminals in ipsilateral Lissauer's tract and lateral laminae I and V.

    In plain wordsIn cats, cutting the sacral nerve roots on one side strongly reduced fibres with the body's own VIP on that side of the spinal cord.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP axons after sacral dorsal root transection
    Study

    catn: not reported in source

    spinal cord, immunohistochemistry
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    Following unilateral transection of the sacral dorsal roots (2 weeks-22 months) the density of VIP axons and terminals was markedly reduced in ipsilateral Lissauer's tract and lateral laminae I and V

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  8. 08AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In cats, unilateral sacral dorsal root transection did not change VIP axons in lamina X.

    In plain wordsIn cats, cutting the sacral nerve roots on one side did not change fibres with the body's own VIP in lamina X.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeVIP axons in lamina X after sacral dorsal root transection
    Study

    catn: not reported in source

    spinal cord, immunohistochemistry
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    however, no change was detected in lamina X.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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