Changes in keratin expression during the estrogen-mediated differentiation of rat vaginal epithelium.

Kronenberg MS, Clark JH

Endocrinology1 Oct 1985Cited by 19 (Europe PMC)

PMID2411529DOI10.1210/endo-117-4-1480PepBankPUB-02411529

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In rats, enclomiphene produced vaginal keratin expression patterns and intensity levels resembling the 24-h stage of estradiol treatment.
In plain wordsIn rats, enclomiphene produced vaginal keratin patterns and levels similar to the 24-h stage of estradiol treatment.
Peptide
Enclomiphene
Outcome
Not applicableKeratin expression pattern and intensity
Study
ratn: not reported in source
Rat vaginal epithelium
Comparator
24-h estradiol treatment
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated · 48 hAs given in this study (rat).
Source sentences
Summary
Under these circumstances, diethylstilbestrol provided a more potent stimulus than E2, while estriol, enclomiphene and zuclomiphene each produced a pattern of keratin expression and intensity levels that resembled that 24-h stage of E2 treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
By way of comparison, four other estrogenic compounds were also evaluated after their administration under a 48-h double injection protocol.
Report a problemFND-0241152901

Studies that did not test the peptide alone3

In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Enclomiphene.

02AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Activity measurement
In rat vaginal epithelium, the evaluated estrogenic compounds, including enclomiphene, often increased keratin synthesis 10- to 20-fold.
In plain wordsIn rats, the evaluated estrogenic compounds, including enclomiphene, often increased keratin synthesis.
Peptide
Enclomiphene
Outcome
IncreaseSelective keratin synthesis
Study
ratn: not reported in source
Rat vaginal epithelium
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Measurements
Keratin synthesis increase
10 to 20 fold
evaluated estrogenic compounds
Source sentences
Summary
Although the same keratins were expressed by these different compounds, their synthesis was selective, since they often increased 10- to 20-fold while total protein levels only doubled.
2 context sentences(design, population, supporting numbers)
Summary · context
Under these circumstances, diethylstilbestrol provided a more potent stimulus than E2, while estriol, enclomiphene and zuclomiphene each produced a pattern of keratin expression and intensity levels that resembled that 24-h stage of E2 treatment.
Summary · context
By way of comparison, four other estrogenic compounds were also evaluated after their administration under a 48-h double injection protocol.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0241152902
03AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Activity measurement
In rat vaginal epithelium, total protein levels doubled during treatment with the evaluated estrogenic compounds, including enclomiphene.
In plain wordsIn rats, total vaginal protein levels doubled during treatment with the evaluated estrogenic compounds, including enclomiphene.
Peptide
Enclomiphene
Outcome
IncreaseTotal protein levels
Study
ratn: not reported in source
Rat vaginal epithelium
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Although the same keratins were expressed by these different compounds, their synthesis was selective, since they often increased 10- to 20-fold while total protein levels only doubled.
2 context sentences(design, population, supporting numbers)
Summary · context
Under these circumstances, diethylstilbestrol provided a more potent stimulus than E2, while estriol, enclomiphene and zuclomiphene each produced a pattern of keratin expression and intensity levels that resembled that 24-h stage of E2 treatment.
Summary · context
By way of comparison, four other estrogenic compounds were also evaluated after their administration under a 48-h double injection protocol.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0241152903
04AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Activity measurement
In rats, vaginal keratin levels across the evaluated estrogenic compounds correlated with epithelial growth and differentiation.
In plain wordsIn rats, vaginal keratin levels across the tested estrogenic compounds were linked to epithelial growth and differentiation.
Peptide
Enclomiphene
Outcome
Direction not reportedAssociation of keratin levels with epithelial growth and differentiation
Study
ratn: not reported in source
Rat vaginal epithelium
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Keratin levels were correlated with the various degrees of epithelial growth and differentiation observed in parallel histological studies.
1 context sentence(design, population, supporting numbers)
Summary · context
Under these circumstances, diethylstilbestrol provided a more potent stimulus than E2, while estriol, enclomiphene and zuclomiphene each produced a pattern of keratin expression and intensity levels that resembled that 24-h stage of E2 treatment.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0241152904

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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