Selective improvement of thymus and some T cell dysfunctions in NZB mice by in utero thymulin treatment.

Quéré P, Dardenne M, Bach MA

Journal of immunology (Baltimore, Md. : 1950)1 Aug 1985Cited by 1 (Europe PMC)

PMID2409141DOI10.4049/jimmunol.135.2.1180PepBankPUB-02409141

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
Maternal thymulin reduced anti-SRBC antibody production versus zinc or saline in NZB offspring, with effects tending to strengthen with postnatal age.
In plain wordsIn mice, maternal thymulin reduced offspring anti-SRBC antibodies versus zinc or saline, with effects tending to strengthen with age.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseAnti-SRBC antibody production
Study
mousen: not reported in source
NZB offspring
Comparator
NZB offspring of zinc- or saline-treated mothers
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
However, marked reductions in anti-SRBC and anti-HGG antibody production, both thymus-dependent responses, were observed in the young NZB offspring of thymulin-treated mothers as compared with NZB controls born from zinc- or saline-treated mothers.
3 context sentences(design, population, supporting numbers)
Summary · context
Interestingly, these effects of in utero thymulin treatment tended to become more pronounced with advancing age during the postnatal period.
Summary · context
NZB mice were treated during gestation with thymulin, a thymus-secreted, zinc-associated nonapeptide.
Summary · context
Control pregnant NZB mice received either zinc alone or saline alone.
Report a problemFND-0240914102
02AnimalAnimal study (in vivo)Efficacy outcome
Maternal thymulin reduced anti-HGG antibody production versus zinc or saline in NZB offspring, with effects tending to strengthen with postnatal age.
In plain wordsIn mice, maternal thymulin reduced offspring anti-HGG antibodies versus zinc or saline, with effects tending to strengthen with age.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseAnti-HGG antibody production
Study
mousen: not reported in source
NZB offspring
Comparator
NZB offspring of zinc- or saline-treated mothers
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
However, marked reductions in anti-SRBC and anti-HGG antibody production, both thymus-dependent responses, were observed in the young NZB offspring of thymulin-treated mothers as compared with NZB controls born from zinc- or saline-treated mothers.
3 context sentences(design, population, supporting numbers)
Summary · context
Interestingly, these effects of in utero thymulin treatment tended to become more pronounced with advancing age during the postnatal period.
Summary · context
NZB mice were treated during gestation with thymulin, a thymus-secreted, zinc-associated nonapeptide.
Summary · context
Control pregnant NZB mice received either zinc alone or saline alone.
Report a problemFND-0240914103
03AnimalAnimal study (in vivo)Efficacy outcome
Maternal thymulin delayed the serum thymulin decrease in NZB offspring versus controls, with effects tending to strengthen with postnatal age.
In plain wordsIn mice, maternal thymulin delayed the offspring thymulin decrease versus controls, with effects tending to strengthen with age.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseDelay in postnatal serum thymulin decrease
Study
mousen: not reported in source
NZB offspring
Comparator
NZB offspring of zinc- or saline-treated mothers
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
A delay in the postnatal decrease of serum thymulin levels was also noted in the offspring of thymulin-treated mothers.
3 context sentences(design, population, supporting numbers)
Summary · context
Interestingly, these effects of in utero thymulin treatment tended to become more pronounced with advancing age during the postnatal period.
Summary · context
NZB mice were treated during gestation with thymulin, a thymus-secreted, zinc-associated nonapeptide.
Summary · context
Control pregnant NZB mice received either zinc alone or saline alone.
Report a problemFND-0240914104
04AnimalAnimal study (in vivo)Efficacy outcome
Thymulin treatment during fetal life did not affect serum IgM levels in NZB offspring.
In plain wordsIn mice, fetal thymulin treatment did not change serum IgM levels compared with controls.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeSerum IgM levels
Study
mousen: not reported in source
NZB offspring
Comparator
NZB offspring of zinc- or saline-treated mothers
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Conversely, IgM serum levels, spontaneous anti-TNP PFC and sensitivity to tolerance induction were not affected by thymulin treatment during fetal life.
2 context sentences(design, population, supporting numbers)
Summary · context
NZB mice were treated during gestation with thymulin, a thymus-secreted, zinc-associated nonapeptide.
Summary · context
Control pregnant NZB mice received either zinc alone or saline alone.
Report a problemFND-0240914105
05AnimalAnimal study (in vivo)Efficacy outcome
Thymulin treatment during fetal life did not affect spontaneous anti-TNP plaque-forming cells in NZB offspring.
In plain wordsIn mice, fetal thymulin treatment did not change spontaneous anti-TNP antibody-producing cells compared with controls.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeSpontaneous anti-TNP plaque-forming cells
Study
mousen: not reported in source
NZB offspring
Comparator
NZB offspring of zinc- or saline-treated mothers
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Conversely, IgM serum levels, spontaneous anti-TNP PFC and sensitivity to tolerance induction were not affected by thymulin treatment during fetal life.
2 context sentences(design, population, supporting numbers)
Summary · context
NZB mice were treated during gestation with thymulin, a thymus-secreted, zinc-associated nonapeptide.
Summary · context
Control pregnant NZB mice received either zinc alone or saline alone.
Report a problemFND-0240914106
06AnimalAnimal study (in vivo)Efficacy outcome
Thymulin treatment during fetal life did not affect sensitivity to tolerance induction in NZB offspring.
In plain wordsIn mice, fetal thymulin treatment did not change sensitivity to tolerance induction compared with controls.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeSensitivity to tolerance induction
Study
mousen: not reported in source
NZB offspring
Comparator
NZB offspring of zinc- or saline-treated mothers
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Conversely, IgM serum levels, spontaneous anti-TNP PFC and sensitivity to tolerance induction were not affected by thymulin treatment during fetal life.
2 context sentences(design, population, supporting numbers)
Summary · context
NZB mice were treated during gestation with thymulin, a thymus-secreted, zinc-associated nonapeptide.
Summary · context
Control pregnant NZB mice received either zinc alone or saline alone.
Report a problemFND-0240914107

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

07AnimalEndogenous levelAnimal study (in vivo)Other
Young NZB mice had lower circulating thymulin titers than DBA/2 mice.
In plain wordsIn mice, natural thymulin levels were lower in young NZB mice than in DBA/2 mice.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseCirculating thymulin titers
Study
mousen: not reported in source
NZB offspring
Comparator
Age-matched DBA/2 mice
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
As compared with DBA/2 mice, young NZB mice exhibited low circulating thymulin titers
2 context sentences(design, population, supporting numbers)
Summary · context
NZB mice were treated during gestation with thymulin, a thymus-secreted, zinc-associated nonapeptide.
Summary · context
Control pregnant NZB mice received either zinc alone or saline alone.
This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240914101

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:55 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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