Chronic regulation of ovarian oxytocin and progesterone release by prostaglandins: opposite effects in bovine granulosa and early luteal cells.

McArdle CA

The Journal of endocrinology1 Aug 1990Cited by 9 (Europe PMC)

PMID2401866DOI10.1677/joe.0.1260245PepBankPUB-02401866

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured7

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01LabEndogenous levelIn vitro (cells)Other
In bovine granulosa cells, chronic exposure to insulin increased the release of oxytocin.
In plain wordsIn cow ovary cells, long exposure to insulin raised the release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
IncreaseInsulin-stimulated oxytocin release in granulosa cells
Study
cattlen: not reported in source
cultured bovine granulosa and early luteal cells
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In granulosa cells, chronic exposure to insulin (17 nmol/l) stimulated luteinization as indicated by increased release of oxytocin and progesterone.
1 context sentence(design, population, supporting numbers)
Summary · context
In this work, the regulation of granulosa and luteal cells by prostaglandins and insulin (or insulin-like growth factor-I; IGF-I) has been explored by comparing their effects on oxytocin and progesterone production in cell culture.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240186601
02LabEndogenous levelIn vitro (cells)Other
In bovine granulosa cells, prostaglandin F2 alpha alone had little effect on oxytocin release.
In plain wordsIn cow ovary cells, prostaglandin F2 alpha alone did little to the release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
No significant changeEffect of PGF2 alpha alone on oxytocin release in granulosa cells
Study
cattlen: not reported in source
cultured bovine granulosa and early luteal cells
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Prostaglandin F2 alpha (PGF2 alpha) alone had little effect
1 context sentence(design, population, supporting numbers)
Summary · context
In this work, the regulation of granulosa and luteal cells by prostaglandins and insulin (or insulin-like growth factor-I; IGF-I) has been explored by comparing their effects on oxytocin and progesterone production in cell culture.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240186602
03LabEndogenous levelIn vitro (cells)Other
In bovine granulosa cells, prostaglandin F2 alpha synergized with insulin or IGF-I to increase oxytocin release.
In plain wordsIn cow ovary cells, prostaglandin F2 alpha together with insulin or IGF-I raised the release of the body's own oxytocin more than either alone.
Peptide
Oxytocin
Outcome
IncreaseOxytocin release with PGF2 alpha plus insulin or IGF-I in granulosa cells
Study
cattlen: not reported in source
cultured bovine granulosa and early luteal cells
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Prostaglandin F2 alpha (PGF2 alpha) alone had little effect, but synergized with insulin (or IGF-I) to increase the release of both these hormones.
1 context sentence(design, population, supporting numbers)
Summary · context
In this work, the regulation of granulosa and luteal cells by prostaglandins and insulin (or insulin-like growth factor-I; IGF-I) has been explored by comparing their effects on oxytocin and progesterone production in cell culture.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240186603
04LabEndogenous levelIn vitro (cells)Other
In bovine early luteal cells, prostaglandin F2 alpha inhibited insulin-stimulated oxytocin production.
In plain wordsIn cow ovary cells at an early luteal stage, prostaglandin F2 alpha lowered the insulin-driven release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
DecreaseInsulin-stimulated oxytocin production in luteal cells with PGF2 alpha
Study
cattlen: not reported in source
cultured bovine granulosa and early luteal cells
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In direct contrast, insulin-stimulated oxytocin production by luteal cells was inhibited by PGF2 alpha.
1 context sentence(design, population, supporting numbers)
Summary · context
In this work, the regulation of granulosa and luteal cells by prostaglandins and insulin (or insulin-like growth factor-I; IGF-I) has been explored by comparing their effects on oxytocin and progesterone production in cell culture.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240186604
05LabEndogenous levelIn vitro (cells)Other
In bovine granulosa cells, 1 mumol PGF2 alpha/l reduced the EC50 of insulin for oxytocin release from 141 to 13 nmol/l.
In plain wordsIn cow ovary cells, prostaglandin F2 alpha made insulin work at a much lower dose to raise the body's own oxytocin release.
Peptide
Oxytocin
Outcome
DecreaseInsulin potency (EC50) for oxytocin release in granulosa cells with PGF2 alpha
Study
cattlen: not reported in source
cultured bovine granulosa and early luteal cells
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
EC50 insulin for oxytocin release
141 nmol/l
granulosa cells without PGF2 alpha
EC50 insulin for oxytocin release
13 nmol/l
granulosa cells with 1 mumol PGF2 alpha/l
Source sentences
Summary
Dose-response studies revealed that PGF2 alpha increased the potency of insulin in granulosa cells (EC50 for insulin-stimulation of oxytocin release reduced from 141 to 13 nmol/l by 1 mumol PGF2 alpha/l)
1 context sentence(design, population, supporting numbers)
Summary · context
In this work, the regulation of granulosa and luteal cells by prostaglandins and insulin (or insulin-like growth factor-I; IGF-I) has been explored by comparing their effects on oxytocin and progesterone production in cell culture.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240186605
06LabEndogenous levelIn vitro (cells)Other
In bovine early luteal cells, PGF2 alpha did not increase the potency of insulin for oxytocin release.
In plain wordsIn early luteal cow cells, prostaglandin F2 alpha did not lower the insulin dose needed for the body's own oxytocin release.
Peptide
Oxytocin
Outcome
No significant changeInsulin potency for oxytocin release in luteal cells with PGF2 alpha
Study
cattlen: not reported in source
cultured bovine granulosa and early luteal cells
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
but not in luteal cells.
1 context sentence(design, population, supporting numbers)
Summary · context
In this work, the regulation of granulosa and luteal cells by prostaglandins and insulin (or insulin-like growth factor-I; IGF-I) has been explored by comparing their effects on oxytocin and progesterone production in cell culture.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240186606
07LabEndogenous levelIn vitro (cells)Other
In bovine granulosa cells, PGE1, PGE2 and forskolin synergistically increased insulin-stimulated oxytocin release.
In plain wordsIn cow ovary cells, PGE1, PGE2 and forskolin each raised insulin-driven release of the body's own oxytocin more than insulin alone.
Peptide
Oxytocin
Outcome
IncreaseInsulin-stimulated oxytocin release in granulosa cells with PGE1, PGE2 or forskolin
Study
cattlen: not reported in source
cultured bovine granulosa and early luteal cells
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Insulin-stimulated oxytocin release from granulosa cells was also synergistically increased
1 context sentence(design, population, supporting numbers)
Summary · context
In this work, the regulation of granulosa and luteal cells by prostaglandins and insulin (or insulin-like growth factor-I; IGF-I) has been explored by comparing their effects on oxytocin and progesterone production in cell culture.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0240186607

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

Subjects

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