Anabolic effect of human synthetic parathyroid hormone-(1-34) depends on growth hormone.

Hock JM, Fonseca J

Endocrinology1 Oct 1990Cited by 47 (Europe PMC)

PMID2401235DOI10.1210/endo-127-4-1804PepBankPUB-02401235

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In sham-operated rats, PTH increased bone calcium by approximately 30%.
In plain wordsIn sham-operated rats, PTH increased bone calcium by approximately 30%.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone calcium in shams
Study
ratn: not reported in source
Sham-operated or hypophysectomized young male rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g once daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
PTH increased bone Ca, DW, and hydroxyproline in shams by approximately 30%, but consistently failed to induce an anabolic response in HX rats.
4 context sentences(design, population, supporting numbers)
Summary · context
We tested whether GH is required for the anabolic effect of PTH on bone, using sham-operated (sham) and hypophysectomized (HX) young male rats.
Summary · context
HX rats were supplemented daily with 3% sucrose water, T4, and corticosterone.
Summary · context
Rats received vehicle or human PTH-(1-34) at 8 micrograms/100 g, sc, once daily, alone or in combination with rat or ovine GH at 0.2 mg/100 g, sc, twice daily or 12 micrograms ovine GH/100 g.day by continuous sc infusion.
Summary · context
After 12 days, rats were sedated, and blood, femurs, and tibias were removed.
Report a problemFND-0240123501
02AnimalAnimal study (in vivo)Efficacy outcome
In sham-operated rats, PTH increased bone dry weight by approximately 30%.
In plain wordsIn sham-operated rats, PTH increased bone dry weight by approximately 30%.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone dry weight in shams
Study
ratn: not reported in source
Sham-operated or hypophysectomized young male rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g once daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
PTH increased bone Ca, DW, and hydroxyproline in shams by approximately 30%, but consistently failed to induce an anabolic response in HX rats.
4 context sentences(design, population, supporting numbers)
Summary · context
We tested whether GH is required for the anabolic effect of PTH on bone, using sham-operated (sham) and hypophysectomized (HX) young male rats.
Summary · context
HX rats were supplemented daily with 3% sucrose water, T4, and corticosterone.
Summary · context
Rats received vehicle or human PTH-(1-34) at 8 micrograms/100 g, sc, once daily, alone or in combination with rat or ovine GH at 0.2 mg/100 g, sc, twice daily or 12 micrograms ovine GH/100 g.day by continuous sc infusion.
Summary · context
After 12 days, rats were sedated, and blood, femurs, and tibias were removed.
Report a problemFND-0240123502
03AnimalAnimal study (in vivo)Efficacy outcome
In sham-operated rats, PTH increased bone hydroxyproline by approximately 30%.
In plain wordsIn sham-operated rats, PTH increased bone hydroxyproline by approximately 30%.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone hydroxyproline in shams
Study
ratn: not reported in source
Sham-operated or hypophysectomized young male rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g once daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
PTH increased bone Ca, DW, and hydroxyproline in shams by approximately 30%, but consistently failed to induce an anabolic response in HX rats.
4 context sentences(design, population, supporting numbers)
Summary · context
We tested whether GH is required for the anabolic effect of PTH on bone, using sham-operated (sham) and hypophysectomized (HX) young male rats.
Summary · context
HX rats were supplemented daily with 3% sucrose water, T4, and corticosterone.
Summary · context
Rats received vehicle or human PTH-(1-34) at 8 micrograms/100 g, sc, once daily, alone or in combination with rat or ovine GH at 0.2 mg/100 g, sc, twice daily or 12 micrograms ovine GH/100 g.day by continuous sc infusion.
Summary · context
After 12 days, rats were sedated, and blood, femurs, and tibias were removed.
Report a problemFND-0240123503
04AnimalAnimal study (in vivo)Efficacy outcome
In hypophysectomized rats, PTH consistently failed to induce an anabolic bone response.
In plain wordsIn rats with removed pituitary glands, PTH consistently failed to stimulate bone growth.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeAnabolic response in hypophysectomized rats
Study
ratn: not reported in source
Sham-operated or hypophysectomized young male rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g once daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
PTH increased bone Ca, DW, and hydroxyproline in shams by approximately 30%, but consistently failed to induce an anabolic response in HX rats.
4 context sentences(design, population, supporting numbers)
Summary · context
We tested whether GH is required for the anabolic effect of PTH on bone, using sham-operated (sham) and hypophysectomized (HX) young male rats.
Summary · context
HX rats were supplemented daily with 3% sucrose water, T4, and corticosterone.
Summary · context
Rats received vehicle or human PTH-(1-34) at 8 micrograms/100 g, sc, once daily, alone or in combination with rat or ovine GH at 0.2 mg/100 g, sc, twice daily or 12 micrograms ovine GH/100 g.day by continuous sc infusion.
Summary · context
After 12 days, rats were sedated, and blood, femurs, and tibias were removed.
Report a problemFND-0240123504
05AnimalAnimal study (in vivo)Efficacy outcome
In hypophysectomized rats, PTH added to GH increased total bone mass approximately 20% versus GH alone.
In plain wordsIn rats with removed pituitary glands, PTH added to GH increased total bone mass approximately 20% versus GH alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone mass versus GH alone
Study
ratn: not reported in source
Sham-operated or hypophysectomized young male rats
Comparator
GH alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g once daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
Total bone mass in these rats was approximately 20% more (P less than 0.05) than the bone mass of rats given GH alone.
5 context sentences(design, population, supporting numbers)
Summary · context
The anabolic effect of PTH was restored in HX rats given both PTH and GH.
Summary · context
We tested whether GH is required for the anabolic effect of PTH on bone, using sham-operated (sham) and hypophysectomized (HX) young male rats.
Summary · context
HX rats were supplemented daily with 3% sucrose water, T4, and corticosterone.
Summary · context
Rats received vehicle or human PTH-(1-34) at 8 micrograms/100 g, sc, once daily, alone or in combination with rat or ovine GH at 0.2 mg/100 g, sc, twice daily or 12 micrograms ovine GH/100 g.day by continuous sc infusion.
Summary · context
After 12 days, rats were sedated, and blood, femurs, and tibias were removed.
Report a problemFND-0240123506
06AnimalAnimal study (in vivo)Efficacy outcome
In food-restricted sham-operated rats, PTH still increased bone mass.
In plain wordsIn food-restricted sham-operated rats, PTH still increased bone mass.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone mass with restricted food
Study
ratn: not reported in source
Sham-operated or hypophysectomized young male rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8 micrograms/100 g once daily · subcutaneous · 12 daysAs given in this study (rat).
Source sentences
Summary
When food was restricted in shams to limit systemic growth, PTH still induced an increase in bone mass.
4 context sentences(design, population, supporting numbers)
Summary · context
We tested whether GH is required for the anabolic effect of PTH on bone, using sham-operated (sham) and hypophysectomized (HX) young male rats.
Summary · context
HX rats were supplemented daily with 3% sucrose water, T4, and corticosterone.
Summary · context
Rats received vehicle or human PTH-(1-34) at 8 micrograms/100 g, sc, once daily, alone or in combination with rat or ovine GH at 0.2 mg/100 g, sc, twice daily or 12 micrograms ovine GH/100 g.day by continuous sc infusion.
Summary · context
After 12 days, rats were sedated, and blood, femurs, and tibias were removed.
Report a problemFND-0240123507

Studies that did not test the peptide alone1

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

07AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In hypophysectomized rats, combined PTH and GH restored the anabolic bone response.
In plain wordsIn rats with removed pituitary glands, combined PTH and GH restored the bone growth response.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseAnabolic response with GH
Study
ratn: not reported in source
Sham-operated or hypophysectomized young male rats
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The anabolic effect of PTH was restored in HX rats given both PTH and GH.
4 context sentences(design, population, supporting numbers)
Summary · context
We tested whether GH is required for the anabolic effect of PTH on bone, using sham-operated (sham) and hypophysectomized (HX) young male rats.
Summary · context
HX rats were supplemented daily with 3% sucrose water, T4, and corticosterone.
Summary · context
Rats received vehicle or human PTH-(1-34) at 8 micrograms/100 g, sc, once daily, alone or in combination with rat or ovine GH at 0.2 mg/100 g, sc, twice daily or 12 micrograms ovine GH/100 g.day by continuous sc infusion.
Summary · context
After 12 days, rats were sedated, and blood, femurs, and tibias were removed.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-0240123505

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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