Restoration of axial and appendicular bone volumes by h-PTH(1-34) in parathyroidectomized and osteopenic rats.

Tada K, Yamamuro T, Okumura H, Kasai R, Takahashi H

Bone1 Jan 1990Cited by 47 (Europe PMC)

PMID2390374DOI10.1016/8756-3282(90)90210-pPepBankPUB-02390374

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In parathyroidectomized and osteopenic rats, hPTH(1-34) significantly restored cancellous bone volume in axial and appendicular skeletons.
In plain wordsIn rats with removed parathyroid glands and low bone mass, hPTH restored spongy bone volume in axial and limb skeletons.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCancellous bone volume
Study
ratn: not reported in source
Parathyroidectomized and osteopenic rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 units (15 micrograms) six times weekly · intramuscular · weeks 11 through 18As given in this study (rat).
Source sentences
Summary
Significant restoration of cancellous and cortical bone volumes was observed in axial and appendicular skeletons of animals treated with h-PTH(1-34).
3 context sentences(design, population, supporting numbers)
Summary · context
Effects of h-PTH(1-34) were histomorphometrically evaluated in both cancellous and cortical bone tissues of axial and appendicular skeletons of parathyroidectomized and osteopenic rats.
Summary · context
Osteopenia was induced by hemicordotomy immobilization and by estrogen depletion as a result of ovariectomy.
Summary · context
The rats received intramuscular injections of 50 units (15 micrograms) of h-PTH(1-34) six times weekly during weeks 11 through 18 of the experiment.
Report a problemFND-0239037401
02AnimalAnimal study (in vivo)Efficacy outcome
In parathyroidectomized and osteopenic rats, hPTH(1-34) significantly restored cortical bone volume in axial and appendicular skeletons.
In plain wordsIn rats with removed parathyroid glands and low bone mass, hPTH restored cortical bone volume in axial and limb skeletons.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCortical bone volume
Study
ratn: not reported in source
Parathyroidectomized and osteopenic rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 units (15 micrograms) six times weekly · intramuscular · weeks 11 through 18As given in this study (rat).
Source sentences
Summary
Significant restoration of cancellous and cortical bone volumes was observed in axial and appendicular skeletons of animals treated with h-PTH(1-34).
3 context sentences(design, population, supporting numbers)
Summary · context
Effects of h-PTH(1-34) were histomorphometrically evaluated in both cancellous and cortical bone tissues of axial and appendicular skeletons of parathyroidectomized and osteopenic rats.
Summary · context
Osteopenia was induced by hemicordotomy immobilization and by estrogen depletion as a result of ovariectomy.
Summary · context
The rats received intramuscular injections of 50 units (15 micrograms) of h-PTH(1-34) six times weekly during weeks 11 through 18 of the experiment.
Report a problemFND-0239037402
03AnimalAnimal study (in vivo)Efficacy outcome
In parathyroidectomized and osteopenic rats, hPTH(1-34) stimulated cancellous osteoid surface independently of eroded surface.
In plain wordsIn rats, hPTH increased unmineralized bone surface in spongy bone independently of eroded surface.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCancellous osteoid surface
Study
ratn: not reported in source
Parathyroidectomized and osteopenic rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 units (15 micrograms) six times weekly · intramuscular · weeks 11 through 18As given in this study (rat).
Source sentences
Summary
The stimulatory effects of h-PTH(1-34) on osteoid surface, independent of eroded surface, in cancellous and cortical bone tissues, were clearly observed histomorphometrically.
3 context sentences(design, population, supporting numbers)
Summary · context
Effects of h-PTH(1-34) were histomorphometrically evaluated in both cancellous and cortical bone tissues of axial and appendicular skeletons of parathyroidectomized and osteopenic rats.
Summary · context
Osteopenia was induced by hemicordotomy immobilization and by estrogen depletion as a result of ovariectomy.
Summary · context
The rats received intramuscular injections of 50 units (15 micrograms) of h-PTH(1-34) six times weekly during weeks 11 through 18 of the experiment.
Report a problemFND-0239037403
04AnimalAnimal study (in vivo)Efficacy outcome
In parathyroidectomized and osteopenic rats, hPTH(1-34) stimulated cortical osteoid surface independently of eroded surface.
In plain wordsIn rats, hPTH increased unmineralized bone surface in cortical bone independently of eroded surface.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCortical osteoid surface
Study
ratn: not reported in source
Parathyroidectomized and osteopenic rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 units (15 micrograms) six times weekly · intramuscular · weeks 11 through 18As given in this study (rat).
Source sentences
Summary
The stimulatory effects of h-PTH(1-34) on osteoid surface, independent of eroded surface, in cancellous and cortical bone tissues, were clearly observed histomorphometrically.
3 context sentences(design, population, supporting numbers)
Summary · context
Effects of h-PTH(1-34) were histomorphometrically evaluated in both cancellous and cortical bone tissues of axial and appendicular skeletons of parathyroidectomized and osteopenic rats.
Summary · context
Osteopenia was induced by hemicordotomy immobilization and by estrogen depletion as a result of ovariectomy.
Summary · context
The rats received intramuscular injections of 50 units (15 micrograms) of h-PTH(1-34) six times weekly during weeks 11 through 18 of the experiment.
Report a problemFND-0239037404
05AnimalAnimal study (in vivo)Efficacy outcome
In parathyroidectomized and osteopenic rats, hPTH(1-34) markedly increased cancellous mineralizing surface.
In plain wordsIn rats, hPTH markedly increased mineralizing surface in spongy bone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCancellous mineralizing surface
Study
ratn: not reported in source
Parathyroidectomized and osteopenic rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 units (15 micrograms) six times weekly · intramuscular · weeks 11 through 18As given in this study (rat).
Source sentences
Summary
Mineralizing surface, mineral apposition rate and bone formation rate in cancellous bone tissues were markedly increased by h-PTH(1-34).
3 context sentences(design, population, supporting numbers)
Summary · context
Effects of h-PTH(1-34) were histomorphometrically evaluated in both cancellous and cortical bone tissues of axial and appendicular skeletons of parathyroidectomized and osteopenic rats.
Summary · context
Osteopenia was induced by hemicordotomy immobilization and by estrogen depletion as a result of ovariectomy.
Summary · context
The rats received intramuscular injections of 50 units (15 micrograms) of h-PTH(1-34) six times weekly during weeks 11 through 18 of the experiment.
Report a problemFND-0239037405
06AnimalAnimal study (in vivo)Efficacy outcome
In parathyroidectomized and osteopenic rats, hPTH(1-34) markedly increased cancellous mineral apposition rate.
In plain wordsIn rats, hPTH markedly increased the rate of mineral accumulation in spongy bone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCancellous mineral apposition rate
Study
ratn: not reported in source
Parathyroidectomized and osteopenic rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 units (15 micrograms) six times weekly · intramuscular · weeks 11 through 18As given in this study (rat).
Source sentences
Summary
Mineralizing surface, mineral apposition rate and bone formation rate in cancellous bone tissues were markedly increased by h-PTH(1-34).
3 context sentences(design, population, supporting numbers)
Summary · context
Effects of h-PTH(1-34) were histomorphometrically evaluated in both cancellous and cortical bone tissues of axial and appendicular skeletons of parathyroidectomized and osteopenic rats.
Summary · context
Osteopenia was induced by hemicordotomy immobilization and by estrogen depletion as a result of ovariectomy.
Summary · context
The rats received intramuscular injections of 50 units (15 micrograms) of h-PTH(1-34) six times weekly during weeks 11 through 18 of the experiment.
Report a problemFND-0239037406
07AnimalAnimal study (in vivo)Efficacy outcome
In parathyroidectomized and osteopenic rats, hPTH(1-34) markedly increased cancellous bone formation rate.
In plain wordsIn rats, hPTH markedly increased spongy bone formation rate.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCancellous bone formation rate
Study
ratn: not reported in source
Parathyroidectomized and osteopenic rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 units (15 micrograms) six times weekly · intramuscular · weeks 11 through 18As given in this study (rat).
Source sentences
Summary
Mineralizing surface, mineral apposition rate and bone formation rate in cancellous bone tissues were markedly increased by h-PTH(1-34).
3 context sentences(design, population, supporting numbers)
Summary · context
Effects of h-PTH(1-34) were histomorphometrically evaluated in both cancellous and cortical bone tissues of axial and appendicular skeletons of parathyroidectomized and osteopenic rats.
Summary · context
Osteopenia was induced by hemicordotomy immobilization and by estrogen depletion as a result of ovariectomy.
Summary · context
The rats received intramuscular injections of 50 units (15 micrograms) of h-PTH(1-34) six times weekly during weeks 11 through 18 of the experiment.
Report a problemFND-0239037407
08AnimalAnimal study (in vivo)Efficacy outcome
In parathyroidectomized and osteopenic rats, hPTH(1-34) increased trabecular thickness.
In plain wordsIn rats, hPTH increased the thickness of spongy bone struts.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTrabecular thickness
Study
ratn: not reported in source
Parathyroidectomized and osteopenic rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 units (15 micrograms) six times weekly · intramuscular · weeks 11 through 18As given in this study (rat).
Source sentences
Summary
It should be noted that h-PTH(1-34) increased trabecular thickness, but did not increase trabecular number.
3 context sentences(design, population, supporting numbers)
Summary · context
Effects of h-PTH(1-34) were histomorphometrically evaluated in both cancellous and cortical bone tissues of axial and appendicular skeletons of parathyroidectomized and osteopenic rats.
Summary · context
Osteopenia was induced by hemicordotomy immobilization and by estrogen depletion as a result of ovariectomy.
Summary · context
The rats received intramuscular injections of 50 units (15 micrograms) of h-PTH(1-34) six times weekly during weeks 11 through 18 of the experiment.
Report a problemFND-0239037408
09AnimalAnimal study (in vivo)Efficacy outcome
In parathyroidectomized and osteopenic rats, hPTH(1-34) did not increase trabecular number.
In plain wordsIn rats, hPTH did not increase the number of spongy bone struts.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeTrabecular number
Study
ratn: not reported in source
Parathyroidectomized and osteopenic rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 units (15 micrograms) six times weekly · intramuscular · weeks 11 through 18As given in this study (rat).
Source sentences
Summary
It should be noted that h-PTH(1-34) increased trabecular thickness, but did not increase trabecular number.
3 context sentences(design, population, supporting numbers)
Summary · context
Effects of h-PTH(1-34) were histomorphometrically evaluated in both cancellous and cortical bone tissues of axial and appendicular skeletons of parathyroidectomized and osteopenic rats.
Summary · context
Osteopenia was induced by hemicordotomy immobilization and by estrogen depletion as a result of ovariectomy.
Summary · context
The rats received intramuscular injections of 50 units (15 micrograms) of h-PTH(1-34) six times weekly during weeks 11 through 18 of the experiment.
Report a problemFND-0239037409

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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