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Study · Animal study (in vivo) · rat · 1990

2 results

Local cerebral blood flow following the intrastriatal administration of vasoactive intestinal peptide or peptide histidine isoleucine in the rat.

Tuor UI, Edvinsson L, Kelly PA, McCulloch J

Regulatory peptides1 May 1990Cited by 4 (Europe PMC)

PMID2377741 (opens in a new tab)DOI10.1016/0167-0115(90)90023-p (opens in a new tab)PepBankPUB-02377741
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intrastriatal VIP raised striatal blood flow in 4 of 8 animals, but the mean 10% rise versus the contralateral side was not significant.

    In plain wordsIn rats, VIP injected into the brain raised local blood flow in some animals, but the average rise was not significant.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeLocal cerebral blood flow near injection site
    Study

    ratn = 8

    intrastriatal microinjection with quantitative autoradiography
    Comparator
    Contralateral striatum
    Outcome group
    Cerebral blood flow · Nervous system and cognition
    Studied dose
    20 pmol · intrastriatal injectionAs given in this study (rat).

    Measurements

    Mean blood flow elevation
    10%
    VIP versus contralateral striatum

    Source sentences

    Summary
    In contrast, following VIP administration (20 pmol), blood flow in proximity to the injection site was increased compared to flow in the contralateral striatum in 4/8 animals with the mean flow being elevated by 10% (n.s.) compared to blood flow contralaterally.
    1 context sentence
    Summary · context
    In 37 rats, an injection needle was inserted into a chronically implanted guide cannula and 1 microliter of vehicle, VIP or PHI was injected into the striatum.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, VIP had an effect on local cerebral glucose utilization in the caudate nucleus equivalent to that of sham animals.

    In plain wordsIn rats, VIP did not change brain glucose use in the caudate nucleus compared with sham animals.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeLocal cerebral glucose utilization in caudate nucleus
    Study

    ratn: not reported in source

    intrastriatal microinjection with quantitative autoradiography
    Comparator
    Sham animals
    Outcome group
    Cerebral blood flow · Nervous system and cognition
    Studied dose
    20 pmol · intrastriatal injectionAs given in this study (rat).

    Source sentences

    Summary
    VIP and PHI had similar effects on local cerebral glucose utilization in the caudate nucleus, their response being equivalent to that of sham animals.
    1 context sentence
    Summary · context
    In 37 rats, an injection needle was inserted into a chronically implanted guide cannula and 1 microliter of vehicle, VIP or PHI was injected into the striatum.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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