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Study · In vitro (cells) · 1990

3 results

Thymosin alpha 1 enhancement of human lymphocyte proliferation is not mediated by prostaglandin E2.

Colarian J, Sethi A, Merchant A, Parikh N, Mutchnick M

Thymus1 Jun 1990Cited by 1 (Europe PMC)

PMID2368121 (opens in a new tab)PepBankPUB-02368121
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human peripheral blood mononuclear cells stimulated with concanavalin A, TA-1 enhanced the proliferative response over mitogen alone.

    In plain wordsIn lab tests on human white blood cells, thymosin alpha‑1 increased cell growth compared with the stimulus alone.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseMitogen-stimulated lymphocyte proliferation
    Study

    humann: not reported in source

    peripheral blood mononuclear cells stimulated with concanavalin A
    Comparator
    Mitogen alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both TA-1 and indomethacin significantly enhanced the proliferative response over that seen with mitogen alone
    1 context sentence
    Summary · context
    In the present study human peripheral blood mononuclear cells were stimulated with concanavalin A in the presence of TA-1, prostaglandin E2 and indomethacin individually, or in combination.
  2. 02LabIn vitro (cells)Mechanism

    In human mononuclear cells, prostaglandin E2 up to 250 ng/ml did not abolish the TA-1 enhancement of proliferation.

    In plain wordsIn lab tests on human white blood cells, prostaglandin E2 did not cancel the growth-boosting effect of thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeTA-1 effect with prostaglandin E2
    Study

    humann: not reported in source

    peripheral blood mononuclear cells stimulated with concanavalin A
    Comparator
    TA-1 without prostaglandin E2
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    prostaglandin E2 (up to 250 ng/ml) did not abolish thymosin effect.
    1 context sentence
    Summary · context
    In the present study human peripheral blood mononuclear cells were stimulated with concanavalin A in the presence of TA-1, prostaglandin E2 and indomethacin individually, or in combination.

Studies that did not test the peptide alone1

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 03LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Mechanism

    In human mononuclear cells, adding indomethacin to TA-1 did not alter the TA-1 effect on proliferation.

    In plain wordsIn lab tests on human white blood cells, adding indomethacin did not change the effect of thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeTA-1 effect with indomethacin
    Study

    humann: not reported in source

    peripheral blood mononuclear cells stimulated with concanavalin A
    Comparator
    TA-1 without indomethacin
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The combination of indomethacin and TA-1 did not alter TA-1 effect
    1 context sentence
    Summary · context
    In the present study human peripheral blood mononuclear cells were stimulated with concanavalin A in the presence of TA-1, prostaglandin E2 and indomethacin individually, or in combination.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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