Skip to content

Study · Animal study (in vivo) · rat · 1990

2 results

Co-circulating sleep substances interactingly modulate sleep and wakefulness in rats.

Inoué S, Kimura-Takeuchi M, Honda K

Endocrinologia experimentalis1 Mar 1990Cited by 3 (Europe PMC)

PMID2361467 (opens in a new tab)PepBankPUB-02361467
Publisher pageAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, third-ventricle infusion of DSIP enhanced the nocturnal amount of slow wave sleep compared with the previous night under saline.

    In plain wordsIn male rats, DSIP infused into the brain increased slow wave sleep compared with a night with saline.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSlow wave sleep amount
    Study

    ratn: not reported in source

    Freely behaving male rats, third ventricle infusion
    Comparator
    Saline infusion on the previous night
    Outcome group
    Sleep · Sleep
    Studied dose
    2.5 nmol · third ventricle infusion · 10 hAs given in this study (rat).

    Source sentences

    Summary
    SWS was enhanced by the d-type of di-1-methylheptyl-2,5-dioxocyclohexane-1,4-dicarboxylate (d-DOC, 2.3 nmol), delta-sleep-inducing peptide (DSIP 2.5 nmol), deoxyuridine (0.1 nmol), muramyl dipeptide (MDP, 2.0 nmol), and prostaglandin D2 (PGD2, 0.36 nmol).
    2 context sentences
    Summary · context
    Putative sleep substances were infused either singly or in combination into the third ventricle of freely behaving male rats for 10 h nocturnal period.
    Summary · context
    The nocturnal amount of slow wave sleep (SWS) and paradoxical sleep (PS), and the number and duration of their episodes were compared to those of the previous night under saline infusion.

Studies that did not test the peptide alone1

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In male rats, simultaneous or sequential infusion of DSIP, muramyl dipeptide and uridine changed sleep-waking dynamics in a combination-dependent or sequence-dependent way that differed from each substance given alone.

    In plain wordsIn male rats, giving DSIP with two other sleep substances changed sleep patterns differently from each substance given alone.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedSleep-waking dynamics after combined DSIP, MDP and uridine
    Study

    ratn: not reported in source

    Freely behaving male rats, third ventricle infusion
    Comparator
    Single administration of each substance
    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    The simultaneous or sequential administration of DSIP, MDP and uridine resulted in a combination-dependent or sequence-dependent change in sleep-waking dynamics, which was quite different from the time-course sleep-modulation induced by the single administration of each substance.
    2 context sentences
    Summary · context
    Putative sleep substances were infused either singly or in combination into the third ventricle of freely behaving male rats for 10 h nocturnal period.
    Summary · context
    The nocturnal amount of slow wave sleep (SWS) and paradoxical sleep (PS), and the number and duration of their episodes were compared to those of the previous night under saline infusion.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.