Thymic hormones and prostaglandins. II. Synergistic effect on mouse spontaneous rosette forming cells.

Homo-Delarche F, Gagnerault MC, Bach JF, Dardenne M

Prostaglandins1 Mar 1990Cited by 2 (Europe PMC)

PMID2339201DOI10.1016/0090-6980(90)90049-2PepBankPUB-02339201

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

01LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism
In mouse rosette assays, PGE2 synergized with thymulin.
In plain wordsIn lab tests, PGE2 and thymulin acted together in mouse rosette assays.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreasePGE2 synergy in rosette assay
Study
mousen: not reported in source
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
We demonstrated that PGE2 and 6-keto-PGF1 alpha are the PGs which are physiologically involved in the rosette assay, according to their levels of endogenous production, and that they are able to synergize with thymulin.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated a possible role for each endogenously produced PG in the experimental conditions of the rosette assay, in order to define: 1) whether or not there was a specificity of action of a given PG; and 2) to analyze the pattern of action between thymulin and the endogenously produced PGs.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0233920101
02LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism
In mouse rosette assays, 6-keto-PGF1 alpha synergized with thymulin.
In plain wordsIn lab tests, 6-keto-PGF1 alpha and thymulin acted together in mouse rosette assays.
Peptide
Thymulin (serum thymic factor)
Outcome
Increase6-keto-PGF1 alpha synergy in rosette assay
Study
mousen: not reported in source
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
We demonstrated that PGE2 and 6-keto-PGF1 alpha are the PGs which are physiologically involved in the rosette assay, according to their levels of endogenous production, and that they are able to synergize with thymulin.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated a possible role for each endogenously produced PG in the experimental conditions of the rosette assay, in order to define: 1) whether or not there was a specificity of action of a given PG; and 2) to analyze the pattern of action between thymulin and the endogenously produced PGs.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0233920102
03LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism
In mouse rosette assays, anti-PGE2 antibody prevented part of the thymulin effect.
In plain wordsIn lab tests, blocking PGE2 reduced part of thymulin's effect in mouse rosette assays.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseThymulin effect with anti-PGE2 antibody
Study
mousen: not reported in source
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
This synergy was demonstrated in two ways: 1) by adding anti-PGE2 and anti-6-keto PGF1 alpha-antibodies, which prevent part of the thymulin effect, or 2) by simultaneous addition of PG and thymulin, at concentrations far lower than those which correspond to their thymulin-like effect.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated a possible role for each endogenously produced PG in the experimental conditions of the rosette assay, in order to define: 1) whether or not there was a specificity of action of a given PG; and 2) to analyze the pattern of action between thymulin and the endogenously produced PGs.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0233920103
04LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism
In mouse rosette assays, anti-6-keto-PGF1 alpha antibody prevented part of the thymulin effect.
In plain wordsIn lab tests, blocking 6-keto-PGF1 alpha reduced part of thymulin's effect in mouse rosette assays.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseThymulin effect with anti-6-keto-PGF1 alpha antibody
Study
mousen: not reported in source
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
This synergy was demonstrated in two ways: 1) by adding anti-PGE2 and anti-6-keto PGF1 alpha-antibodies, which prevent part of the thymulin effect, or 2) by simultaneous addition of PG and thymulin, at concentrations far lower than those which correspond to their thymulin-like effect.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated a possible role for each endogenously produced PG in the experimental conditions of the rosette assay, in order to define: 1) whether or not there was a specificity of action of a given PG; and 2) to analyze the pattern of action between thymulin and the endogenously produced PGs.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0233920104

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:55 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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