Skip to content

Study · Ex vivo tissue · 1990

2 results

Motor responsiveness of proximal and distal human colonic muscle layers to acetylcholine, noradrenaline, and vasoactive intestinal peptide.

Burleigh DE

Digestive diseases and sciences1 May 1990Cited by 12 (Europe PMC)

PMID2331955 (opens in a new tab)DOI10.1007/bf01540410 (opens in a new tab)PepBankPUB-02331955
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In human colonic circular muscle strips, the distal colon was more sensitive to VIP than the proximal colon.

    In plain wordsIn lab tests on human colon muscle, the distal circular muscle responded to VIP more than the proximal circular muscle.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP sensitivity of circular muscle, distal versus proximal colon
    Study

    humann: not reported in source

    circular and longitudinal muscle strips from human colon
    Comparator
    Proximal colon circular muscle
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the circular muscle of the distal colon was more sensitive to vasoactive intestinal peptide than was the circular muscle of the proximal colon.
    1 context sentence
    Summary · context
    Using circular and longitudinal muscle strips from proximal and distal human colon, the present study sought to determine whether such regional differences were apparent in smooth muscle responsiveness to neurohumoral agents.
  2. 02LabEx vivo tissueEfficacy outcome

    In human colonic longitudinal muscle strips from both regions, sensitivity to VIP was comparatively low.

    In plain wordsIn lab tests on human colon muscle, the long muscle layer from both regions responded little to VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP sensitivity of longitudinal muscle
    Study

    humann: not reported in source

    circular and longitudinal muscle strips from human colon
    Comparator
    Circular muscle
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Longitudinal muscle from both regions was comparatively insensitive to VIP.
    1 context sentence
    Summary · context
    Using circular and longitudinal muscle strips from proximal and distal human colon, the present study sought to determine whether such regional differences were apparent in smooth muscle responsiveness to neurohumoral agents.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.