Vascular effects of helodermin, helospectin I and helospectin II: a comparison with vasoactive intestinal peptide (VIP).

Grundemar L, Högestätt ED

British journal of pharmacology1 Mar 1990Cited by 28 (Europe PMC)

PMID2331581PMCIDPMC1917339DOI10.1111/j.1476-5381.1990.tb12962.xPepBankPUB-02331581

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, VIP reduced blood pressure in a dose-dependent manner, and helodermin was less effective than VIP.
In plain wordsIn rats, VIP lowered blood pressure in a dose-dependent way, and more than helodermin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseBlood pressure reduction, dose-dependence
Study
ratn: not reported in source
systemic blood pressure in rats
Comparator
Helodermin, helospectin I and II
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
They all reduced blood pressure in a dose-dependent manner; helodermin was less effective than VIP.
1 context sentence(design, population, supporting numbers)
Summary · context
Helodermin, helospectin I and helospectin II, peptides recently isolated from the salivary gland venom of Heloderma suspectum, were compared to vasoactive intestinal peptide (VIP) with respect to effects on systemic blood pressure and on isolated femoral arteries in the rat.
Report a problemFND-0233158101
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, at doses above 1 nmol/kg VIP reduced blood pressure to about the same extent as helodermin and the helospectins.
In plain wordsIn rats, at higher doses VIP lowered blood pressure about as much as helodermin and the helospectins.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseBlood pressure reduction at doses above 1 nmol/kg
Study
ratn: not reported in source
systemic blood pressure in rats
Comparator
Helodermin, helospectin I and II
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
However, at doses higher than 1 nmol kg-1 all four peptides reduced blood pressure to about the same extent.
1 context sentence(design, population, supporting numbers)
Summary · context
Helodermin, helospectin I and helospectin II, peptides recently isolated from the salivary gland venom of Heloderma suspectum, were compared to vasoactive intestinal peptide (VIP) with respect to effects on systemic blood pressure and on isolated femoral arteries in the rat.
Report a problemFND-0233158102
03AnimalAnimal study (in vivo)Pharmacokinetics
In rats, the half-life of the hypotensive effect of VIP was longer than that of helodermin and the helospectins.
In plain wordsIn rats, the blood pressure drop from VIP lasted longer than that from helodermin and the helospectins.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableHalf-life of the hypotensive effect
Study
ratn: not reported in source
systemic blood pressure in rats
Comparator
Helodermin, helospectin I and II
Outcome group
Pharmacokinetics · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
The half-life of the hypotensive effect of VIP was longer than that of helodermin and the helospectins.
1 context sentence(design, population, supporting numbers)
Summary · context
Helodermin, helospectin I and helospectin II, peptides recently isolated from the salivary gland venom of Heloderma suspectum, were compared to vasoactive intestinal peptide (VIP) with respect to effects on systemic blood pressure and on isolated femoral arteries in the rat.
Report a problemFND-0233158103
04LabEx vivo tissueEfficacy outcome
In isolated rat femoral arteries precontracted with phenylephrine or prostaglandin F2 alpha, VIP and helodermin were equally potent in relaxing the vessels.
In plain wordsIn lab tests on rat arteries, VIP relaxed pre-tightened vessels as strongly as helodermin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation of precontracted femoral arteries
Study
ratn: not reported in source
isolated femoral arteries
Comparator
Helodermin, helospectin I and II
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
VIP and helodermin were equally potent in relaxing femoral arteries precontracted with phenylephrine or prostaglandin F2 alpha.
1 context sentence(design, population, supporting numbers)
Summary · context
Helodermin, helospectin I and helospectin II, peptides recently isolated from the salivary gland venom of Heloderma suspectum, were compared to vasoactive intestinal peptide (VIP) with respect to effects on systemic blood pressure and on isolated femoral arteries in the rat.
Report a problemFND-0233158104
05LabEx vivo tissueMechanism
In isolated rat femoral arteries, adding VIP 1 microM to vessels exposed to helodermin or the helospectins did not produce further relaxation.
In plain wordsIn lab tests on rat arteries, adding VIP to vessels already relaxed by helodermin or helospectins gave no extra relaxation.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeAdditional relaxation by VIP after helodermin or helospectin
Study
ratn: not reported in source
isolated femoral arteries
Comparator
Helodermin, helospectin I and II
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
1 microMAs given in this study (rat).
Source sentences
Summary
Addition of VIP 1 microM to preparations exposed to helodermin 1 microM or to either of the helospectins did not produce a further relaxation.
1 context sentence(design, population, supporting numbers)
Summary · context
Helodermin, helospectin I and helospectin II, peptides recently isolated from the salivary gland venom of Heloderma suspectum, were compared to vasoactive intestinal peptide (VIP) with respect to effects on systemic blood pressure and on isolated femoral arteries in the rat.
Report a problemFND-0233158105
06LabEx vivo tissueEfficacy outcome
In isolated rat femoral arteries contracted with phenylephrine, helospectin I and II relaxed the vessels to the same extent as VIP but with a lower potency.
In plain wordsIn lab tests on rat arteries, helospectin I and II relaxed tightened vessels as much as VIP, but needed more peptide to do so.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation by helospectin I and II versus VIP
Study
ratn: not reported in source
isolated femoral arteries
Comparator
Helospectin I and II
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Helospectin I and II relaxed phenylephrine-contracted vessels to the same extent as VIP but with a lower potency.
1 context sentence(design, population, supporting numbers)
Summary · context
Helodermin, helospectin I and helospectin II, peptides recently isolated from the salivary gland venom of Heloderma suspectum, were compared to vasoactive intestinal peptide (VIP) with respect to effects on systemic blood pressure and on isolated femoral arteries in the rat.
Report a problemFND-0233158106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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