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Study · Randomized controlled trial · n = 16 · 1990

15 results

Effects of short term administration of recombinant human growth hormone to elderly people.

Marcus R, Butterfield G, Holloway L, Gilliland L, Baylink DJ, Hintz RL, Sherman BM

The Journal of clinical endocrinology and metabolism1 Feb 1990Cited by 198 (Europe PMC)

PMID2298863 (opens in a new tab)DOI10.1210/jcem-70-2-519 (opens in a new tab)PepBankPUB-02298863
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. 15 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In elderly adults, rhGH increased circulating somatomedin-C in a dose-dependent manner.

    In plain wordsIn elderly adults, rhGH increased circulating somatomedin-C from baseline, with larger rises at higher doses.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseCirculating somatomedin-C
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Source sentences

    Summary
    A brisk rise in circulating somatomedin-C (insulin-like growth factor-I) occurred in all subjects, and this rise was dose dependent.
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  2. 02HumanNon-randomized trialEfficacy outcome

    In elderly adults, rhGH reduced urinary nitrogen excretion from 8.00 to 5.01 g (P less than 0.001).

    In plain wordsIn elderly adults, rhGH reduced urinary nitrogen excretion from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseUrinary nitrogen excretion
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Measurements

    Urinary nitrogen
    8 g
    baseline
    Urinary nitrogen
    5.01 g
    rhGH

    Source sentences

    Summary
    Twenty-four-hour urinary nitrogen excretion decreased from 8.00 +/- 0.33 to 5.01 +/- 0.33 g (P less than 0.001), and sodium excretion decreased from 45.9 +/- 2.96 to 21.2 +/- 3.48 mmol/day (P less than 0.001).
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  3. 03HumanNon-randomized trialEfficacy outcome

    In elderly adults, rhGH reduced sodium excretion from 45.9 to 21.2 mmol/day (P less than 0.001).

    In plain wordsIn elderly adults, rhGH reduced sodium excretion from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseSodium excretion
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Measurements

    Sodium excretion
    45.9 mmol/day
    baseline
    Sodium excretion
    21.2 mmol/day
    rhGH

    Source sentences

    Summary
    Twenty-four-hour urinary nitrogen excretion decreased from 8.00 +/- 0.33 to 5.01 +/- 0.33 g (P less than 0.001), and sodium excretion decreased from 45.9 +/- 2.96 to 21.2 +/- 3.48 mmol/day (P less than 0.001).
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  4. 04HumanNon-randomized trialEfficacy outcome

    In elderly adults, rhGH did not change serum calcium concentrations.

    In plain wordsIn elderly adults, rhGH did not change serum calcium from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeSerum calcium
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Source sentences

    Summary
    Serum calcium concentrations did not change, but serum inorganic phosphorus levels of 1.08 +/- 0.04 mmol/L at baseline increased significantly after rhGH treatment to 1.33 +/- 0.04 mmol/L (P less than 0.001).
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  5. 05HumanNon-randomized trialEfficacy outcome

    In elderly adults, rhGH increased serum inorganic phosphorus from 1.08 to 1.33 mmol/L (P less than 0.001).

    In plain wordsIn elderly adults, rhGH increased serum inorganic phosphorus from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSerum inorganic phosphorus
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Measurements

    Phosphorus
    1.08 mmol/L
    baseline
    Phosphorus
    1.33 mmol/L
    rhGH

    Source sentences

    Summary
    Serum calcium concentrations did not change, but serum inorganic phosphorus levels of 1.08 +/- 0.04 mmol/L at baseline increased significantly after rhGH treatment to 1.33 +/- 0.04 mmol/L (P less than 0.001).
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  6. 06HumanNon-randomized trialEfficacy outcome

    In elderly adults, rhGH increased circulating PTH to 53.2 from 39.5 ng/L (P less than 0.01).

    In plain wordsIn elderly adults, rhGH increased circulating PTH from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseCirculating PTH
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Bone and joint · Endocrine and hormones
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Measurements

    PTH
    53.2 ng/L
    rhGH
    PTH
    39.5 ng/L
    baseline

    Source sentences

    Summary
    Increases were also observed in circulating PTH (53.2 +/- 6 vs. 39.5 +/- 4.2 ng/L; P less than 0.01) and calcitriol (82.8 vs. 65.8 pmol/L; P less than 0.05).
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  7. 07HumanNon-randomized trialEfficacy outcome

    In elderly adults, rhGH increased calcitriol to 82.8 from 65.8 pmol/L (P less than 0.05).

    In plain wordsIn elderly adults, rhGH increased calcitriol from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseCalcitriol
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Bone and joint · Endocrine and hormones
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Measurements

    Calcitriol
    82.8 pmol/L
    rhGH
    Calcitriol
    65.8 pmol/L
    baseline

    Source sentences

    Summary
    Increases were also observed in circulating PTH (53.2 +/- 6 vs. 39.5 +/- 4.2 ng/L; P less than 0.01) and calcitriol (82.8 vs. 65.8 pmol/L; P less than 0.05).
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  8. 08HumanNon-randomized trialEfficacy outcome

    In elderly adults, rhGH increased serum osteocalcin to 10.3 from 8.0 micrograms/L (P less than 0.05).

    In plain wordsIn elderly adults, rhGH increased serum osteocalcin from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSerum osteocalcin
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Measurements

    Osteocalcin
    10.3 micrograms/L
    rhGH
    Osteocalcin
    8 micrograms/L
    baseline

    Source sentences

    Summary
    A rise in serum osteocalcin (10.3 +/- .86 vs. 8.0 +/- 0.5 micrograms/L; P less than 0.05) was accompanied by increased urinary excretion of hydroxyproline (628 +/- 63 vs. 406 +/- 44 mumol/day; P less than 0.01).
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  9. 09HumanNon-randomized trialEfficacy outcome

    In elderly adults, rhGH increased urinary hydroxyproline to 628 from 406 mumol/day (P less than 0.01).

    In plain wordsIn elderly adults, rhGH increased urinary hydroxyproline from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseUrinary hydroxyproline
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Measurements

    Hydroxyproline
    628 mumol/day
    rhGH
    Hydroxyproline
    406 mumol/day
    baseline

    Source sentences

    Summary
    A rise in serum osteocalcin (10.3 +/- .86 vs. 8.0 +/- 0.5 micrograms/L; P less than 0.05) was accompanied by increased urinary excretion of hydroxyproline (628 +/- 63 vs. 406 +/- 44 mumol/day; P less than 0.01).
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  10. 10HumanNon-randomized trialEfficacy outcome

    In elderly adults, rhGH increased urinary calcium to 6.04 from 3.27 mmol/day (P less than 0.01).

    In plain wordsIn elderly adults, rhGH increased urinary calcium from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseUrinary calcium
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Measurements

    Urinary calcium
    6.04 mmol/day
    rhGH
    Urinary calcium
    3.27 mmol/day
    baseline

    Source sentences

    Summary
    Despite the reduction in sodium excretion, marked increases were observed in urinary calcium (6.04 +/- 0.97 vs. 3.27 +/- 0.40 mmol/day; P less than 0.01).
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  11. 11HumanNon-randomized trialSafety outcome

    In elderly adults, rhGH significantly impaired oral glucose tolerance.

    In plain wordsIn elderly adults, rhGH worsened oral glucose tolerance from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseOral glucose tolerance
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Source sentences

    Summary
    rhGH significantly impaired oral glucose tolerance and reduced insulin sensitivity, but was otherwise well tolerated and produced no systematic changes in weight or blood pressure.
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  12. 12HumanNon-randomized trialSafety outcome

    In elderly adults, rhGH reduced insulin sensitivity.

    In plain wordsIn elderly adults, rhGH reduced insulin sensitivity from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseInsulin sensitivity
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Source sentences

    Summary
    rhGH significantly impaired oral glucose tolerance and reduced insulin sensitivity, but was otherwise well tolerated and produced no systematic changes in weight or blood pressure.
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  13. 13HumanNon-randomized trialSafety outcome

    In elderly adults, rhGH was otherwise well tolerated.

    In plain wordsIn elderly adults, rhGH was otherwise well tolerated.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableTolerability
    Study

    n = 16

    Outcome group
    Adverse events · Whole body
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Source sentences

    Summary
    rhGH significantly impaired oral glucose tolerance and reduced insulin sensitivity, but was otherwise well tolerated and produced no systematic changes in weight or blood pressure.
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  14. 14HumanNon-randomized trialEfficacy outcome

    In elderly adults, rhGH produced no systematic weight change.

    In plain wordsIn elderly adults, rhGH produced no systematic weight change from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeBody weight
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Source sentences

    Summary
    rhGH significantly impaired oral glucose tolerance and reduced insulin sensitivity, but was otherwise well tolerated and produced no systematic changes in weight or blood pressure.
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.
  15. 15HumanNon-randomized trialEfficacy outcome

    In elderly adults, rhGH produced no systematic blood pressure change.

    In plain wordsIn elderly adults, rhGH produced no systematic blood pressure change from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeBlood pressure
    Study

    n = 16

    Comparator
    Baseline
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    0.03, 0.06, or 0.12 mg/kg daily · injection · 7 daysAs given in this study (human).

    Source sentences

    Summary
    rhGH significantly impaired oral glucose tolerance and reduced insulin sensitivity, but was otherwise well tolerated and produced no systematic changes in weight or blood pressure.
    2 context sentences
    Summary · context
    We evaluated the effects of recombinant human GH (rhGH) in 16 men and women more than 60 yr of age.
    Summary · context
    After 10 days of dietary equilibration and control collections, subjects were randomly assigned to receive 0.03, 0.06, or 0.12 mg/kg rhGH by daily injection for 7 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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