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Study · Animal study (in vivo) · rat · 1990

9 results

Human parathyroid hormone-(1-34) prevents bone loss and augments bone formation in sexually mature ovariectomized rats.

Liu CC, Kalu DN

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 Sept 1990Cited by 128 (Europe PMC)

PMID2281827 (opens in a new tab)DOI10.1002/jbmr.5650050911 (opens in a new tab)PepBankPUB-02281827
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH increased metaphyseal cancellous bone by over 300%, exceeding sham-operated control levels.

    In plain wordsIn rats with removed ovaries, PTH increased metaphyseal spongy bone by over 300%, exceeding sham-operated control levels.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMetaphyseal cancellous bone
    Study

    ratn: not reported in source

    Sexually mature ovariectomized Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    8 or 16 micrograms per 100 g body weight daily · injection · 5 weeksAs given in this study (rat).

    Measurements

    Cancellous bone increase
    > 300%
    PTH-treated ovariectomized rats

    Source sentences

    Summary
    In contrast, in the ovariectomized animals treated with PTH, the metaphyseal cancellous bone increased by over 300% to a level in excess of that present in the sham-operated control animals.
    2 context sentences
    Summary · context
    A group of 3-month-old Sprague-Dawley rats were sham operated or ovariectomized and given daily injections of human PTH-(1-34) (8 or 16 micrograms per 100 g body weight) for 5 weeks.
    Summary · context
    At the termination of the study histomorphometric techniques were used to examine changes in cortical and cancellous bone in the diaphysis and proximal metaphysis of the tibia.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH-associated cancellous bone gain accompanied an over 70% increase in osteoblasts.

    In plain wordsIn rats with removed ovaries, PTH-associated spongy bone gain accompanied an over 70% increase in bone-forming cells.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular osteoblasts
    Study

    ratn: not reported in source

    Sexually mature ovariectomized Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    8 or 16 micrograms per 100 g body weight daily · injection · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    The increase in cancellous bone induced by PTH was associated with an over 70% increase in osteoblasts and tetracycline-labeled area and an unexpected decrease in trabecular osteoclasts.
    2 context sentences
    Summary · context
    A group of 3-month-old Sprague-Dawley rats were sham operated or ovariectomized and given daily injections of human PTH-(1-34) (8 or 16 micrograms per 100 g body weight) for 5 weeks.
    Summary · context
    At the termination of the study histomorphometric techniques were used to examine changes in cortical and cancellous bone in the diaphysis and proximal metaphysis of the tibia.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH-associated cancellous bone gain accompanied an over 70% increase in tetracycline-labeled area.

    In plain wordsIn rats with removed ovaries, PTH-associated spongy bone gain accompanied an over 70% increase in labeled bone formation area.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTetracycline-labeled area
    Study

    ratn: not reported in source

    Sexually mature ovariectomized Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    8 or 16 micrograms per 100 g body weight daily · injection · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    The increase in cancellous bone induced by PTH was associated with an over 70% increase in osteoblasts and tetracycline-labeled area and an unexpected decrease in trabecular osteoclasts.
    2 context sentences
    Summary · context
    A group of 3-month-old Sprague-Dawley rats were sham operated or ovariectomized and given daily injections of human PTH-(1-34) (8 or 16 micrograms per 100 g body weight) for 5 weeks.
    Summary · context
    At the termination of the study histomorphometric techniques were used to examine changes in cortical and cancellous bone in the diaphysis and proximal metaphysis of the tibia.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH decreased trabecular osteoclasts.

    In plain wordsIn rats with removed ovaries, PTH decreased bone breakdown cells in spongy bone.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseTrabecular osteoclasts
    Study

    ratn: not reported in source

    Sexually mature ovariectomized Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    8 or 16 micrograms per 100 g body weight daily · injection · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    The increase in cancellous bone induced by PTH was associated with an over 70% increase in osteoblasts and tetracycline-labeled area and an unexpected decrease in trabecular osteoclasts.
    2 context sentences
    Summary · context
    A group of 3-month-old Sprague-Dawley rats were sham operated or ovariectomized and given daily injections of human PTH-(1-34) (8 or 16 micrograms per 100 g body weight) for 5 weeks.
    Summary · context
    At the termination of the study histomorphometric techniques were used to examine changes in cortical and cancellous bone in the diaphysis and proximal metaphysis of the tibia.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH decreased tibial diaphyseal endosteal osteoclasts.

    In plain wordsIn rats with removed ovaries, PTH decreased bone breakdown cells at the inner tibial shaft surface.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseDiaphyseal endosteal osteoclasts
    Study

    ratn: not reported in source

    Sexually mature ovariectomized Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    8 or 16 micrograms per 100 g body weight daily · injection · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    In the tibial diaphysis PTH also decreased endosteal osteoclasts and at the same time increased osteoblast size and number as well as endosteal and periosteal bone formation; ovariectomy increased only periosteal bone formation.
    2 context sentences
    Summary · context
    A group of 3-month-old Sprague-Dawley rats were sham operated or ovariectomized and given daily injections of human PTH-(1-34) (8 or 16 micrograms per 100 g body weight) for 5 weeks.
    Summary · context
    At the termination of the study histomorphometric techniques were used to examine changes in cortical and cancellous bone in the diaphysis and proximal metaphysis of the tibia.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH increased tibial diaphyseal osteoblast size.

    In plain wordsIn rats with removed ovaries, PTH increased bone-forming cell size in the tibial shaft.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseDiaphyseal osteoblast size
    Study

    ratn: not reported in source

    Sexually mature ovariectomized Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    8 or 16 micrograms per 100 g body weight daily · injection · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    In the tibial diaphysis PTH also decreased endosteal osteoclasts and at the same time increased osteoblast size and number as well as endosteal and periosteal bone formation; ovariectomy increased only periosteal bone formation.
    2 context sentences
    Summary · context
    A group of 3-month-old Sprague-Dawley rats were sham operated or ovariectomized and given daily injections of human PTH-(1-34) (8 or 16 micrograms per 100 g body weight) for 5 weeks.
    Summary · context
    At the termination of the study histomorphometric techniques were used to examine changes in cortical and cancellous bone in the diaphysis and proximal metaphysis of the tibia.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH increased tibial diaphyseal osteoblast number.

    In plain wordsIn rats with removed ovaries, PTH increased bone-forming cell numbers in the tibial shaft.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseDiaphyseal osteoblast number
    Study

    ratn: not reported in source

    Sexually mature ovariectomized Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    8 or 16 micrograms per 100 g body weight daily · injection · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    In the tibial diaphysis PTH also decreased endosteal osteoclasts and at the same time increased osteoblast size and number as well as endosteal and periosteal bone formation; ovariectomy increased only periosteal bone formation.
    2 context sentences
    Summary · context
    A group of 3-month-old Sprague-Dawley rats were sham operated or ovariectomized and given daily injections of human PTH-(1-34) (8 or 16 micrograms per 100 g body weight) for 5 weeks.
    Summary · context
    At the termination of the study histomorphometric techniques were used to examine changes in cortical and cancellous bone in the diaphysis and proximal metaphysis of the tibia.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH increased tibial endosteal bone formation.

    In plain wordsIn rats with removed ovaries, PTH increased bone formation at the inner tibial surface.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseEndosteal bone formation
    Study

    ratn: not reported in source

    Sexually mature ovariectomized Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    8 or 16 micrograms per 100 g body weight daily · injection · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    In the tibial diaphysis PTH also decreased endosteal osteoclasts and at the same time increased osteoblast size and number as well as endosteal and periosteal bone formation; ovariectomy increased only periosteal bone formation.
    2 context sentences
    Summary · context
    A group of 3-month-old Sprague-Dawley rats were sham operated or ovariectomized and given daily injections of human PTH-(1-34) (8 or 16 micrograms per 100 g body weight) for 5 weeks.
    Summary · context
    At the termination of the study histomorphometric techniques were used to examine changes in cortical and cancellous bone in the diaphysis and proximal metaphysis of the tibia.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH increased tibial periosteal bone formation.

    In plain wordsIn rats with removed ovaries, PTH increased bone formation at the outer tibial surface.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreasePeriosteal bone formation
    Study

    ratn: not reported in source

    Sexually mature ovariectomized Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    8 or 16 micrograms per 100 g body weight daily · injection · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    In the tibial diaphysis PTH also decreased endosteal osteoclasts and at the same time increased osteoblast size and number as well as endosteal and periosteal bone formation; ovariectomy increased only periosteal bone formation.
    2 context sentences
    Summary · context
    A group of 3-month-old Sprague-Dawley rats were sham operated or ovariectomized and given daily injections of human PTH-(1-34) (8 or 16 micrograms per 100 g body weight) for 5 weeks.
    Summary · context
    At the termination of the study histomorphometric techniques were used to examine changes in cortical and cancellous bone in the diaphysis and proximal metaphysis of the tibia.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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