Skip to content

Study · Ex vivo tissue · frog · 1990

4 results

[The atropine-like action, not removed by naloxone, of the opioid dermorphin on the inotropic effects of acetylcholine].

Sokolova NA, Krasil'nikova VG, Ashmarin IP

Nauchnye doklady vysshei shkoly. Biologicheskie nauki1 Jan 1990

PMID2275946 (opens in a new tab)PepBankPUB-02275946
Publisher pageAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In isolated frog hearts, dermorphin reduced contractile force.

    In plain wordsIn lab tests, dermorphin reduced contractile force in isolated frog hearts.

    Peptide
    Dermorphin
    Outcome
    DecreaseNegative inotropic effect
    Study

    frogn: not reported in source

    Isolated perfused heart
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Opioid dermorphin induced a negative inotropic effect on the isolated perfused by Straube frog's heart, this effect was blocked by naloxone.
  2. 02LabEx vivo tissueMechanism

    In isolated frog hearts, acetylcholine inhibited ventricular contraction to the same degree during dermorphin exposure as before exposure.

    In plain wordsIn lab tests, acetylcholine inhibited frog ventricular contraction similarly during dermorphin exposure and before exposure.

    Peptide
    Dermorphin
    Outcome
    No significant changeAcetylcholine-induced ventricular inhibition
    Study

    frogn: not reported in source

    Isolated perfused heart
    Comparator
    Before dermorphin injection
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the background of dermorphin negative inotropic effect acetylcholine inhibited the ventricular contractile activity to the same degree as in the control experiments before dermorphin injection.

Studies that did not test the peptide alone2

In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Dermorphin.

  1. 03LabNot a test of Dermorphin aloneEx vivo tissueMechanism

    In isolated frog hearts, combined naloxone and dermorphin infusion significantly weakened acetylcholine's negative inotropic effect versus control.

    In plain wordsIn lab tests, naloxone with dermorphin weakened acetylcholine's contraction-reducing effect in frog hearts compared with control.

    Peptide
    Dermorphin
    Outcome
    DecreaseAcetylcholine negative inotropic effect with naloxone and dermorphin
    Study

    frogn: not reported in source

    Isolated perfused heart
    Comparator
    Control
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    But after the combined infusion of naloxone and dermorphin removed the opioid inotropic effect, the negative inotropic effect of acetylcholine became significantly weaker than in the control.

    In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dermorphin.

  2. 04LabNot a test of Dermorphin aloneEx vivo tissueMechanism

    In isolated frog hearts, naloxone blocked dermorphin's negative inotropic effect.

    In plain wordsIn lab tests, naloxone blocked dermorphin's contraction-reducing effect in isolated frog hearts.

    Peptide
    Dermorphin
    Outcome
    Not applicableNaloxone blockade of negative inotropic effect
    Study

    frogn: not reported in source

    Isolated perfused heart
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Opioid dermorphin induced a negative inotropic effect on the isolated perfused by Straube frog's heart, this effect was blocked by naloxone.

    In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dermorphin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.