[ Anticataleptic effect of delta sleep-inducing peptide and its action on brain monoamine oxidase in rats genetically predisposed to catalepsy].

Voĭtenko NN, Kolpakov VG, Alekhina TA

Biulleten' eksperimental'noi biologii i meditsiny1 Sept 1990

PMID2268724DOI10.1007/bf00840301PepBankPUB-02268724

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats genetically susceptible to catalepsy, DSIP shortened the duration of cataleptic freezing to 13.8 sec against 27.2 sec in control.
In plain wordsIn rats prone to catalepsy, DSIP shortened freezing time compared with control animals.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseDuration of cataleptic freezing
Study
ratn: not reported in source
Comparator
Control
Outcome group
Locomotor and behavioral activity · Nervous system and cognition
Studied dose
120 micrograms/100 g · intraperitonealAs given in this study (rat).
Measurements
cataleptic freezing duration
13.8 sec
GC rats, DSIP
cataleptic freezing duration
27.2 sec
GC rats, control
Source sentences
Summary
After an intraperitoneal administration of 120 micrograms/100 g delta sleep-inducing peptide (DSIP) in GC rats the duration of cataleptic freezing was shortened (13.8 +/- 9.5 sec against 27.2 +/- 7.5 sec in control).
1 context sentence(design, population, supporting numbers)
Summary · context
Rats with genetic susceptibility to catalepsy (GC strain) were compared with Wistar rats (W).
Report a problemFND-0226872401
02AnimalAnimal study (in vivo)Mechanism
In rats genetically susceptible to catalepsy, DSIP decreased MAO-B activity.
In plain wordsIn rats prone to catalepsy, DSIP lowered the activity of the brain enzyme MAO-B.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseBrain MAO-B activity in GC rats
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
120 micrograms/100 g · intraperitonealAs given in this study (rat).
Source sentences
Summary
MAO-B activity decreased due to DSIP administration both in GC and W rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats with genetic susceptibility to catalepsy (GC strain) were compared with Wistar rats (W).
Report a problemFND-0226872402
03AnimalAnimal study (in vivo)Mechanism
In Wistar rats, DSIP decreased MAO-B activity.
In plain wordsIn Wistar rats, DSIP lowered the activity of the brain enzyme MAO-B.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseBrain MAO-B activity in Wistar rats
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
120 micrograms/100 g · intraperitonealAs given in this study (rat).
Source sentences
Summary
MAO-B activity decreased due to DSIP administration both in GC and W rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats with genetic susceptibility to catalepsy (GC strain) were compared with Wistar rats (W).
Report a problemFND-0226872403

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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