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Study · Animal study (in vivo) · rabbit · 1990

3 results

[Distribution of labeled amino acids and delta-sleep inducing peptide in the body after instillation into the conjunctiva of the rabbit eye].

Badikov VI, Gitel' EP, Ivanova NIa, Ivolgina LG, Fedianina MG, Zaĭtsev DA, Miasoedov NF, Sudakov KV

Biulleten' eksperimental'noi biologii i meditsiny1 Sept 1990

PMID2268701 (opens in a new tab)PepBankPUB-02268701
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, labeled DSIP and amino acids were found in all examined substrates 10 min after conjunctival instillation.

    In plain wordsIn rabbits, DSIP given in the eye reached all tested tissues within 10 minutes.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDistribution of 3H-DSIP at 10 min after conjunctival instillation
    Study

    rabbitn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · conjunctival instillationAs given in this study (rabbit).

    Measurements

    time of detection
    10 min
    all substrates

    Source sentences

    Summary
    Marked amino acids and DSIP were observed in all substrates in 10 min after administration.
    1 context sentence
    Summary · context
    Dynamics of 3H-valine, 3H-glycine and 3H-DSIP distribution in various brain structures, tissues and liquids of an organism due to administration of these substances in eye conjunctive were studied in rabbits with scintillation spectrometry method.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, maximal activity of labeled DSIP and amino acids in the brain visual cortex occurred at 2 h after conjunctival instillation.

    In plain wordsIn rabbits, the highest level of labeled DSIP in the visual cortex of the brain came 2 hours after eye instillation.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableTime of maximal activity in brain visual cortex
    Study

    rabbitn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · conjunctival instillationAs given in this study (rabbit).

    Measurements

    time to maximal activity
    2 h
    brain visual cortex

    Source sentences

    Summary
    Maximal activity was found in 2 h in the brain visual cortex
    1 context sentence
    Summary · context
    Dynamics of 3H-valine, 3H-glycine and 3H-DSIP distribution in various brain structures, tissues and liquids of an organism due to administration of these substances in eye conjunctive were studied in rabbits with scintillation spectrometry method.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, maximal activity of labeled DSIP and amino acids in cardiac tissue, spleen and optical chiasma occurred at 30 min after conjunctival instillation.

    In plain wordsIn rabbits, the highest level of labeled DSIP in heart, spleen and optic chiasm came 30 minutes after eye instillation.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableTime of maximal activity in cardiac tissue, spleen and optical chiasma
    Study

    rabbitn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · conjunctival instillationAs given in this study (rabbit).

    Measurements

    time to maximal activity
    30 min
    cardiac tissue, spleen, optical chiasma

    Source sentences

    Summary
    Maximal activity was found in 2 h in the brain visual cortex and in 30 min in cardiac tissue, spleen and optical chiasma.
    1 context sentence
    Summary · context
    Dynamics of 3H-valine, 3H-glycine and 3H-DSIP distribution in various brain structures, tissues and liquids of an organism due to administration of these substances in eye conjunctive were studied in rabbits with scintillation spectrometry method.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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