Vasoactive intestinal polypeptide facilitates atrioventricular nodal conduction and shortens atrial and ventricular refractory periods in conscious and anesthetized dogs.

Rigel DF, Lathrop DA

Circulation research1 Dec 1990Cited by 14 (Europe PMC)

PMID2245498DOI10.1161/01.res.67.6.1323PepBankPUB-02245498

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In conscious dogs after autonomic blockade, intravenous VIP increased heart rate.
In plain wordsIn dogs, VIP given into a vein raised heart rate.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseHeart rate increase
Study
dogn = 8
conscious chronically instrumented dogs after autonomic blockade
Outcome group
Heart function · Cardiovascular
Studied dose
50 and 100 pmol/kg/min · intravenousAs given in this study (dog).
Measurements
Maximum heart rate increase
81.1 beats/min
VIP
Source sentences
Summary
VIP (50 and 100 pmol/kg/min i.v.) or isoproterenol (ISO) (250 and 500 pmol/kg/min i.v.) increased heart rate (maximum increases: VIP, 81.1 +/- 4.2 beats/min
1 context sentence(design, population, supporting numbers)
Summary · context
Dogs (n = 8) were chronically instrumented with arterial and venous catheters, cervical vagal cooling coils, and right atrial and right ventricular bipolar epicardial pacing and recording electrodes.
Report a problemFND-0224549801
02AnimalAnimal study (in vivo)Efficacy outcome
In conscious dogs after autonomic blockade, VIP decreased the atrial-ventricular interval during constant atrial pacing.
In plain wordsIn dogs, VIP shortened the time for the signal to pass from the upper to the lower heart chambers.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseAtrial-ventricular interval
Study
dogn = 8
conscious chronically instrumented dogs after autonomic blockade
Outcome group
Heart function · Cardiovascular
Studied dose
50 and 100 pmol/kg/min · intravenousAs given in this study (dog).
Measurements
Atrial-ventricular interval change
−41.9 msec
VIP
Source sentences
Summary
decreased the atrial-ventricular interval (during constant atrial pacing) (VIP, -41.9 +/- 6.3 msec
1 context sentence(design, population, supporting numbers)
Summary · context
Dogs (n = 8) were chronically instrumented with arterial and venous catheters, cervical vagal cooling coils, and right atrial and right ventricular bipolar epicardial pacing and recording electrodes.
Report a problemFND-0224549802
03AnimalAnimal study (in vivo)Efficacy outcome
In conscious dogs after autonomic blockade, VIP shortened the atrial effective refractory period.
In plain wordsIn dogs, VIP shortened the recovery time of the upper heart chambers.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseAtrial effective refractory period
Study
dogn = 8
conscious chronically instrumented dogs after autonomic blockade
Outcome group
Heart function · Cardiovascular
Studied dose
50 and 100 pmol/kg/min · intravenousAs given in this study (dog).
Measurements
Atrial effective refractory period change
−24.4 msec
VIP
Source sentences
Summary
shortened the atrial effective refractory period (VIP, -24.4 +/- 2.1 msec
1 context sentence(design, population, supporting numbers)
Summary · context
Dogs (n = 8) were chronically instrumented with arterial and venous catheters, cervical vagal cooling coils, and right atrial and right ventricular bipolar epicardial pacing and recording electrodes.
Report a problemFND-0224549803
04AnimalAnimal study (in vivo)Efficacy outcome
In conscious dogs after autonomic blockade, VIP shortened the ventricular effective refractory period.
In plain wordsIn dogs, VIP shortened the recovery time of the lower heart chambers.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVentricular effective refractory period
Study
dogn = 8
conscious chronically instrumented dogs after autonomic blockade
Outcome group
Heart function · Cardiovascular
Studied dose
50 and 100 pmol/kg/min · intravenousAs given in this study (dog).
Measurements
Ventricular effective refractory period change
−4.2 msec
VIP
Source sentences
Summary
ventricular effective refractory period (VIP, -4.2 +/- 0.7 msec
1 context sentence(design, population, supporting numbers)
Summary · context
Dogs (n = 8) were chronically instrumented with arterial and venous catheters, cervical vagal cooling coils, and right atrial and right ventricular bipolar epicardial pacing and recording electrodes.
Report a problemFND-0224549804
05AnimalAnimal study (in vivo)Efficacy outcome
In conscious dogs after autonomic blockade, VIP decreased mean arterial pressure.
In plain wordsIn dogs, VIP lowered blood pressure.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseMean arterial pressure
Study
dogn = 8
conscious chronically instrumented dogs after autonomic blockade
Outcome group
Blood pressure · Cardiovascular
Studied dose
50 and 100 pmol/kg/min · intravenousAs given in this study (dog).
Measurements
Mean arterial pressure change
−51.9 mm Hg
VIP
Source sentences
Summary
decreased mean arterial pressure (VIP, -51.9 +/- 4.0 mm Hg
1 context sentence(design, population, supporting numbers)
Summary · context
Dogs (n = 8) were chronically instrumented with arterial and venous catheters, cervical vagal cooling coils, and right atrial and right ventricular bipolar epicardial pacing and recording electrodes.
Report a problemFND-0224549805
06AnimalAnimal study (in vivo)Mechanism
In conscious dogs, beta-adrenergic blockade with propranolol did not affect the heart rate and atrioventricular nodal responses to bolus VIP.
In plain wordsIn dogs, blocking beta-adrenergic receptors did not change the heart responses to VIP, so those responses do not depend on them.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP heart rate and AV nodal responses after beta-blockade
Study
dogn = 8
conscious chronically instrumented dogs after autonomic blockade
Comparator
Isoproterenol responses were eliminated by propranolol
Outcome group
Heart function · Cardiovascular
Studied dose
10, 30, 100 and 300 pmol/kg bolus · intravenousAs given in this study (dog).
Source sentences
Summary
beta-Adrenergic blockade with propranolol (1 mg/kg i.v.) eliminated the positive chronotropic and atrioventricular nodal dromotropic responses to bolus doses of ISO (30, 100, 300, and 1,000 pmol/kg i.v.) but did not affect the responses to VIP (10, 30, 100, and 300 pmol/kg i.v.).
1 context sentence(design, population, supporting numbers)
Summary · context
Dogs (n = 8) were chronically instrumented with arterial and venous catheters, cervical vagal cooling coils, and right atrial and right ventricular bipolar epicardial pacing and recording electrodes.
Report a problemFND-0224549806
07AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized dogs after vagotomy and beta-adrenergic blockade, VIP shortened the atrial-His interval.
In plain wordsIn anesthetized dogs, VIP shortened the conduction time from the upper chambers to the His bundle.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseAtrial-His interval
Study
dogn = 3
anesthetized dogs after vagotomy and beta-adrenergic blockade
Outcome group
Heart function · Cardiovascular
Studied dose
100 pmol/kg/min · intravenousAs given in this study (dog).
Source sentences
Summary
In three additional anesthetized dogs, after vagotomy and beta-adrenergic blockade (1 mg/kg i.v. propranolol), VIP (100 pmol/kg/min i.v.) shortened the atrial-His interval but did not alter intra-atrial, intraventricular, or His-Purkinje conduction.
Report a problemFND-0224549807
08AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized dogs after vagotomy and beta-adrenergic blockade, VIP did not alter intra-atrial, intraventricular or His-Purkinje conduction.
In plain wordsIn anesthetized dogs, VIP did not change conduction inside the upper chambers, the lower chambers or the His-Purkinje system.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeIntra-atrial, intraventricular and His-Purkinje conduction
Study
dogn = 3
anesthetized dogs after vagotomy and beta-adrenergic blockade
Outcome group
Heart function · Cardiovascular
Studied dose
100 pmol/kg/min · intravenousAs given in this study (dog).
Source sentences
Summary
In three additional anesthetized dogs, after vagotomy and beta-adrenergic blockade (1 mg/kg i.v. propranolol), VIP (100 pmol/kg/min i.v.) shortened the atrial-His interval but did not alter intra-atrial, intraventricular, or His-Purkinje conduction.
Report a problemFND-0224549808

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Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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Vasoactive intestinal polypeptide facilitates atrioventricular nodal conduction and shortens atrial and ventricular refractory periods in conscious and anesthetized dogs.

Summary

Results from this study8

Version history

Subjects

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MeSH terms