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Study · Non-randomized trial · n = 16 · 1990

5 results

Human growth hormone prevents the protein catabolic side effects of prednisone in humans.

Horber FF, Haymond MW

The Journal of clinical investigation1 Jul 1990Cited by 230 (Europe PMC)

PMID2195062 (opens in a new tab)PMCIDPMC296716 (opens in a new tab)DOI10.1172/jci114694 (opens in a new tab)PepBankPUB-02195062
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy volunteers, hGH alone produced positive protein balance by leucine kinetics versus placebo (P less than 0.001).

    In plain wordsIn healthy volunteers, hGH alone improved protein balance measured by leucine kinetics versus placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseProtein balance by leucine kinetics
    Study

    n = 16

    Comparator
    Placebo
    Outcome group
    Protein and amino acid metabolism · Musculoskeletal
    Studied dose
    0.1 mg.kg-1.d-1 · 7 dAs given in this study (human).

    Source sentences

    Summary
    Whether protein balance was calculated from the leucine kinetic data or nitrogen balance values, prednisone alone induced protein wasting (P less than 0.001), whereas hGH alone resulted in positive (P less than 0.001) protein balance, when compared to the placebo-treated subjects.
    1 context sentence
    Summary · context
    To determine whether concomitant administration of hGH prevents the protein catabolic effects of prednisone, four groups of eight healthy volunteers each were studied using isotope dilution and nitrogen balance techniques
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy volunteers, hGH alone produced positive protein balance by nitrogen balance versus placebo (P less than 0.001).

    In plain wordsIn healthy volunteers, hGH alone improved nitrogen balance versus placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseNitrogen balance
    Study

    n = 16

    Comparator
    Placebo
    Outcome group
    Protein and amino acid metabolism · Musculoskeletal
    Studied dose
    0.1 mg.kg-1.d-1 · 7 dAs given in this study (human).

    Source sentences

    Summary
    Whether protein balance was calculated from the leucine kinetic data or nitrogen balance values, prednisone alone induced protein wasting (P less than 0.001), whereas hGH alone resulted in positive (P less than 0.001) protein balance, when compared to the placebo-treated subjects.
    1 context sentence
    Summary · context
    To determine whether concomitant administration of hGH prevents the protein catabolic effects of prednisone, four groups of eight healthy volunteers each were studied using isotope dilution and nitrogen balance techniques
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy volunteers receiving prednisone, added hGH prevented glucocorticoid-induced protein catabolism.

    In plain wordsIn healthy volunteers taking prednisone, added hGH prevented protein loss compared with prednisone alone.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreasePrednisone-induced protein catabolism
    Study

    n = 16

    Comparator
    Prednisone alone
    Outcome group
    Protein and amino acid metabolism · Musculoskeletal
    Studied dose
    0.1 mg.kg-1.d-1 · 7 dAs given in this study (human).

    Source sentences

    Summary
    When hGH was added to prednisone therapy, the glucocorticoid-induced protein catabolism was prevented.
    2 context sentences
    Summary · context
    To determine whether concomitant administration of hGH prevents the protein catabolic effects of prednisone, four groups of eight healthy volunteers each were studied using isotope dilution and nitrogen balance techniques after 7 d of placebo, hGH alone (0.1 mg.kg-1.d-1), prednisone alone (0.8 mg.kg…
    Summary · context
    To determine whether concomitant administration of hGH prevents the protein catabolic effects of prednisone, four groups of eight healthy volunteers each were studied using isotope dilution and nitrogen balance techniques
  4. 04HumanNon-randomized trialEfficacy outcome

    In healthy volunteers, hGH alone had no effect on proteolysis.

    In plain wordsIn healthy volunteers, hGH alone did not change protein breakdown.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeProteolysis
    Study

    n = 8

    Outcome group
    Protein and amino acid metabolism · Musculoskeletal
    Studied dose
    0.1 mg.kg-1.d-1 · 7 dAs given in this study (human).

    Source sentences

    Summary
    Using leucine kinetic data, negative protein balance during prednisone was due to increased (P less than 0.05) proteolysis, whereas hGH had no effect on proteolysis and increased (P less than 0.01) whole body protein synthesis.
    1 context sentence
    Summary · context
    To determine whether concomitant administration of hGH prevents the protein catabolic effects of prednisone, four groups of eight healthy volunteers each were studied using isotope dilution and nitrogen balance techniques
  5. 05HumanNon-randomized trialEfficacy outcome

    In healthy volunteers, hGH alone increased whole-body protein synthesis (P less than 0.01).

    In plain wordsIn healthy volunteers, hGH alone increased whole-body protein synthesis.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseWhole-body protein synthesis
    Study

    n = 8

    Outcome group
    Protein and amino acid metabolism · Musculoskeletal
    Studied dose
    0.1 mg.kg-1.d-1 · 7 dAs given in this study (human).

    Source sentences

    Summary
    Using leucine kinetic data, negative protein balance during prednisone was due to increased (P less than 0.05) proteolysis, whereas hGH had no effect on proteolysis and increased (P less than 0.01) whole body protein synthesis.
    1 context sentence
    Summary · context
    To determine whether concomitant administration of hGH prevents the protein catabolic effects of prednisone, four groups of eight healthy volunteers each were studied using isotope dilution and nitrogen balance techniques

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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