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Study · Animal study (in vivo) · guinea pig and sheep · 1990

1 result

Circulating neuroactive peptides and the blood-brain and blood-cerebrospinal fluid barriers.

Zlokovic BV, Segal MB, Davson H, Lipovac MN, Hyman S, McComb JG

Endocrinologia experimentalis1 Mar 1990Cited by 17 (Europe PMC)

PMID2193795 (opens in a new tab)PepBankPUB-02193795
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In guinea pig brain and sheep choroid plexus perfusions, DSIP was taken up intact at the luminal side of the blood-brain barrier and blood-tissue interface of the blood-CSF barrier by a saturable mechanism.

    In plain wordsIn guinea pigs and sheep, DSIP entered the brain barriers intact through a mechanism that can be saturated.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableUptake across blood-brain and blood-CSF barriers
    Study

    guinea pig and sheepn: not reported in source

    In situ vascular perfusion of brain (guinea pig) and isolated choroid plexus (sheep)
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · vascular perfusionAs given in this study (guinea pig and sheep).

    Source sentences

    Summary
    It has been demonstrated that Enk-Leu, DSIP and VP-Arg were taken up intact at the luminal side of the blood-brain barrier and blood-tissue interface of the blood-cerebrospinal fluid barrier by a saturable mechanism.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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