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Study · In vitro (cells) · pig · 1990

4 results

Neurohypophyseal peptides and tachykinins stimulate the production of cyclic GMP in cultured porcine aortic endothelial cells.

Schini VB, Katusic ZS, Vanhoutte PM

The Journal of pharmacology and experimental therapeutics1 Dec 1990Cited by 20 (Europe PMC)

PMID2175809 (opens in a new tab)DOI10.1016/s0022-3565(25)23114-7 (opens in a new tab)PepBankPUB-02175809
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cultured porcine aortic endothelial cells, oxytocin markedly and transiently stimulated cyclic GMP production.

    In plain wordsIn cells from pig aorta, oxytocin strongly but briefly raised cyclic GMP production.

    Peptide
    Oxytocin
    Outcome
    IncreaseCyclic GMP production
    Study

    pign: not reported in source

    cultured porcine aortic endothelial cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Arg-vasopressin, oxytocin, substance P and physalae-min (an analog of substance P, pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2) markedly and transiently stimulated the production of cyclic GMP without affecting that of cyclic AMP.
    1 context sentence
    Summary · context
    The response to small peptides such as Arg-vasopressin, oxytocin and tachykinins was investigated in cultured porcine aortic endothelial cells.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured porcine aortic endothelial cells, oxytocin did not affect cyclic AMP production.

    In plain wordsIn cells from pig aorta, oxytocin did not change cyclic AMP production.

    Peptide
    Oxytocin
    Outcome
    No significant changeCyclic AMP production
    Study

    pign: not reported in source

    cultured porcine aortic endothelial cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Arg-vasopressin, oxytocin, substance P and physalae-min (an analog of substance P, pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2) markedly and transiently stimulated the production of cyclic GMP without affecting that of cyclic AMP.
    1 context sentence
    Summary · context
    The response to small peptides such as Arg-vasopressin, oxytocin and tachykinins was investigated in cultured porcine aortic endothelial cells.
  3. 03LabIn vitro (cells)Activity measurement

    In cultured porcine aortic endothelial cells, oxytocin stimulated cyclic GMP accumulation in a concentration-dependent manner and was the most potent of the neurohypophyseal peptides tested.

    In plain wordsIn cells from pig aorta, oxytocin raised cyclic GMP more as the amount rose, and it was the strongest of the related hormones tested.

    Peptide
    Oxytocin
    Outcome
    IncreaseConcentration dependence and relative potency for cyclic GMP accumulation
    Study

    pign: not reported in source

    cultured porcine aortic endothelial cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The neurohypophyseal hormones and related peptides stimulated the accumulation of cyclic GMP in a concentration-dependent manner, with the following relative order of potency: oxytocin greater than Lys-vasopressin greater than Arg-vasopressin much greater than [deamino-Cys1, D-Arg8]-vasopressin.
    1 context sentence
    Summary · context
    The response to small peptides such as Arg-vasopressin, oxytocin and tachykinins was investigated in cultured porcine aortic endothelial cells.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 04LabNot a test of Oxytocin aloneIn vitro (cells)Mechanism

    In cultured porcine aortic endothelial cells, an oxytocin antagonist selectively inhibited the cyclic GMP production that oxytocin evoked.

    In plain wordsIn cells from pig aorta, a drug that blocks the oxytocin receptor reduced the cyclic GMP rise caused by oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-evoked cyclic GMP production with an oxytocin antagonist
    Study

    pign: not reported in source

    cultured porcine aortic endothelial cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    The production of cyclic GMP evoked by oxytocin was inhibited selectively by [d(CH2)5, Tyr(OMe)2, Orn8]-vasotocin, an oxytocin antagonist.
    1 context sentence
    Summary · context
    The response to small peptides such as Arg-vasopressin, oxytocin and tachykinins was investigated in cultured porcine aortic endothelial cells.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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