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Study · In vitro (cells) · rat · 1990

3 results

[The suppression of the contractile activity of the cardiomyocytes by dermorphin in a heart culture of newborn rats].

Ivanova NL, Leĭkina MI, Sokolova NA

Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova1 Mar 1990

PMID2164968 (opens in a new tab)PepBankPUB-02164968
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In newborn rat myocardial cells, dermorphine dose-dependently reduced contraction amplitude with a latency of 5-10 min.

    In plain wordsIn cells from newborn rat hearts, dermorphine reduced contraction amplitude in a dose-dependent manner.

    Peptide
    Dermorphin
    Outcome
    DecreaseContraction amplitude
    Study

    ratn: not reported in source

    Cultured myocardial cells from newborn rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10(-4)-10(-9) MAs given in this study (rat).

    Measurements

    Response latency
    5 to 10 min
    Contraction amplitude reduction

    Source sentences

    Summary
    Dermorphine (10(-4)-10(-9) M) dose-dependently attenuated the contraction amplitude with the latency of 5-10 min.
    1 context sentence
    Summary · context
    In this study, the same effect was investigated in cultured myocardiac cells of the newborn rats.
  2. 02LabIn vitro (cells)Activity measurement

    In newborn rat myocardial cells, the dermorphine response peaked 30-45 min after application.

    In plain wordsIn cells from newborn rat hearts, the dermorphine response peaked after application.

    Peptide
    Dermorphin
    Outcome
    Not applicableTime to peak contractile response
    Study

    ratn: not reported in source

    Cultured myocardial cells from newborn rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10(-4)-10(-9) MAs given in this study (rat).

    Measurements

    Time to peak response
    30 to 45 min
    After dermorphine application

    Source sentences

    Summary
    The peak of the response appeared in 30-45 min after application of dermorphine.
    1 context sentence
    Summary · context
    In this study, the same effect was investigated in cultured myocardiac cells of the newborn rats.

Studies that did not test the peptide alone1

In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Dermorphin.

  1. 03LabNot a test of Dermorphin aloneIn vitro (cells)Mechanism

    In newborn rat myocardial cells, naloxone blocked dermorphine-induced contraction suppression.

    In plain wordsIn cells from newborn rat hearts, naloxone blocked dermorphine-induced contraction suppression.

    Peptide
    Dermorphin
    Outcome
    Not applicableNaloxone sensitivity of contraction suppression
    Study

    ratn: not reported in source

    Cultured myocardial cells from newborn rats
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    The mu-opiate-receptor antagonist naloxone (10(-5) g/ml) blocked this effect.
    1 context sentence
    Summary · context
    In this study, the same effect was investigated in cultured myocardiac cells of the newborn rats.

    In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dermorphin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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