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Study · Animal study (in vivo) · mouse · 1990

3 results

Characterisation and visualisation of [3H]dermorphin binding to mu opioid receptors in the rat brain. Combined high selectivity and affinity in a natural peptide agonist for the morphine (mu) receptor.

Amiche M, Sagan S, Mor A, Pelaprat D, Rostene W, Delfour A, Nicolas P

European journal of biochemistry1 May 1990Cited by 26 (Europe PMC)

PMID2161761 (opens in a new tab)DOI10.1111/j.1432-1033.1990.tb15531.x (opens in a new tab)PepBankPUB-02161761
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, synthetic dermorphin was up to 5 times more active as an analgesic than beta-endorphin.

    In plain wordsIn mice, synthetic dermorphin showed greater analgesic activity than beta-endorphin.

    Peptide
    Dermorphin
    Outcome
    IncreaseAnalgesic potency versus beta-endorphin
    Study

    mousen: not reported in source

    Comparator
    Beta-endorphin
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Measurements

    Relative analgesic activity
    ≤ 5 times
    Versus beta-endorphin

    Source sentences

    Summary
    Finally, intracerebroventricular administration of synthetic dermorphin into mice showed that this peptide is the most potent analgesic known to date, being up to 5 and 670 times more active than beta-endorphin and morphine, respectively.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, synthetic dermorphin was up to 670 times more active as an analgesic than morphine.

    In plain wordsIn mice, synthetic dermorphin showed greater analgesic activity than morphine.

    Peptide
    Dermorphin
    Outcome
    IncreaseAnalgesic potency versus morphine
    Study

    mousen: not reported in source

    Comparator
    Morphine
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Measurements

    Relative analgesic activity
    ≤ 670 times
    Versus morphine

    Source sentences

    Summary
    Finally, intracerebroventricular administration of synthetic dermorphin into mice showed that this peptide is the most potent analgesic known to date, being up to 5 and 670 times more active than beta-endorphin and morphine, respectively.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In mice, higher dermorphin doses induced catalepsy.

    In plain wordsIn mice, higher dermorphin doses induced catalepsy.

    Peptide
    Dermorphin
    Outcome
    IncreaseCatalepsy
    Study

    mousen: not reported in source

    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Higher doses induced catalepsy.
    1 context sentence
    Summary · context
    Finally, intracerebroventricular administration of synthetic dermorphin into mice showed that this peptide is the most potent analgesic known to date, being up to 5 and 670 times more active than beta-endorphin and morphine, respectively.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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