[Analysis of the mechanism of the stress-protective action of delta sleep-inducing peptide].

Iukhananov RIu, Rozhanets VV, Mikhaleva II, Maĭskiĭ AI

Biulleten' eksperimental'noi biologii i meditsiny1 Jan 1990Cited by 3 (Europe PMC)

PMID2159352DOI10.1007/bf00839742PepBankPUB-02159352

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats after 6-hour immobilization, DSIP partly blocked the stress-induced elevation of plasma corticosterone.
In plain wordsIn stressed rats, DSIP partly blocked the stress-related rise in corticosterone.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreasePlasma corticosterone elevation after 6-hour immobilization
Study
ratn: not reported in source
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
0.1 mg/kg · i/pAs given in this study (rat).
Source sentences
Summary
The stress increased the content of corticosterone, ACTH, beta-endorphin, but not insulin in the blood plasma, and the levels of met-enkephalin in the adrenal glands, but decreased the met-enkephalin contents in the striatum. The injection of DSIP (0.1 mg/kg, i/p) blocked partly the elevation of corticosterone only.
1 context sentence(design, population, supporting numbers)
Summary · context
By RIA there were studied the contents of corticosterone, ACTH, beta-endorphin and insulin in the blood plasma, met- and leu-enkephalin in different regions of the rat brain and in the adrenal glands after a 6-hour immobilization.
Report a problemFND-0215935201
02AnimalAnimal study (in vivo)Efficacy outcome
In rats after 6-hour immobilization, DSIP did not block the stress-induced rise in plasma ACTH.
In plain wordsIn stressed rats, DSIP did not block the stress-related rise in ACTH.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changePlasma ACTH elevation after 6-hour immobilization
Study
ratn: not reported in source
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
0.1 mg/kg · i/pAs given in this study (rat).
Source sentences
Summary
The stress increased the content of corticosterone, ACTH, beta-endorphin, but not insulin in the blood plasma, and the levels of met-enkephalin in the adrenal glands, but decreased the met-enkephalin contents in the striatum. The injection of DSIP (0.1 mg/kg, i/p) blocked partly the elevation of corticosterone only.
1 context sentence(design, population, supporting numbers)
Summary · context
By RIA there were studied the contents of corticosterone, ACTH, beta-endorphin and insulin in the blood plasma, met- and leu-enkephalin in different regions of the rat brain and in the adrenal glands after a 6-hour immobilization.
Report a problemFND-0215935202
03AnimalAnimal study (in vivo)Efficacy outcome
In rats after 6-hour immobilization, DSIP did not block the stress-induced rise in plasma beta-endorphin.
In plain wordsIn stressed rats, DSIP did not block the stress-related rise in beta-endorphin.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changePlasma beta-endorphin elevation after 6-hour immobilization
Study
ratn: not reported in source
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
0.1 mg/kg · i/pAs given in this study (rat).
Source sentences
Summary
The stress increased the content of corticosterone, ACTH, beta-endorphin, but not insulin in the blood plasma, and the levels of met-enkephalin in the adrenal glands, but decreased the met-enkephalin contents in the striatum. The injection of DSIP (0.1 mg/kg, i/p) blocked partly the elevation of corticosterone only.
1 context sentence(design, population, supporting numbers)
Summary · context
By RIA there were studied the contents of corticosterone, ACTH, beta-endorphin and insulin in the blood plasma, met- and leu-enkephalin in different regions of the rat brain and in the adrenal glands after a 6-hour immobilization.
Report a problemFND-0215935203
04AnimalAnimal study (in vivo)Efficacy outcome
In rats after 6-hour immobilization, DSIP did not block the stress-induced rise of met-enkephalin in the adrenal glands.
In plain wordsIn stressed rats, DSIP did not block the stress-related rise of met-enkephalin in the adrenal glands.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeMet-enkephalin in adrenal glands after 6-hour immobilization
Study
ratn: not reported in source
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
0.1 mg/kg · i/pAs given in this study (rat).
Source sentences
Summary
The stress increased the content of corticosterone, ACTH, beta-endorphin, but not insulin in the blood plasma, and the levels of met-enkephalin in the adrenal glands, but decreased the met-enkephalin contents in the striatum. The injection of DSIP (0.1 mg/kg, i/p) blocked partly the elevation of corticosterone only.
1 context sentence(design, population, supporting numbers)
Summary · context
By RIA there were studied the contents of corticosterone, ACTH, beta-endorphin and insulin in the blood plasma, met- and leu-enkephalin in different regions of the rat brain and in the adrenal glands after a 6-hour immobilization.
Report a problemFND-0215935204
05AnimalAnimal study (in vivo)Efficacy outcome
In rats after 6-hour immobilization, DSIP did not block the stress-induced fall of met-enkephalin in the striatum.
In plain wordsIn stressed rats, DSIP did not block the stress-related fall of met-enkephalin in the striatum.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeMet-enkephalin in striatum after 6-hour immobilization
Study
ratn: not reported in source
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
0.1 mg/kg · i/pAs given in this study (rat).
Source sentences
Summary
The stress increased the content of corticosterone, ACTH, beta-endorphin, but not insulin in the blood plasma, and the levels of met-enkephalin in the adrenal glands, but decreased the met-enkephalin contents in the striatum. The injection of DSIP (0.1 mg/kg, i/p) blocked partly the elevation of corticosterone only.
1 context sentence(design, population, supporting numbers)
Summary · context
By RIA there were studied the contents of corticosterone, ACTH, beta-endorphin and insulin in the blood plasma, met- and leu-enkephalin in different regions of the rat brain and in the adrenal glands after a 6-hour immobilization.
Report a problemFND-0215935205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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