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Study · Randomized controlled trial · n = 6 · 1990

4 results

The interaction between clonidine and growth hormone releasing hormone in the stimulation of growth hormone secretion in man.

Suri D, Hindmarsh PC, Brain CE, Pringle PJ, Brook CG

Clinical endocrinology1 Sept 1990Cited by 7 (Europe PMC)

PMID2147600 (opens in a new tab)DOI10.1111/j.1365-2265.1990.tb00505.x (opens in a new tab)PepBankPUB-02147600
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In six healthy men, the peak GH response to GHRH was higher when serum GH was rising in the preceding hour than when it was falling or unchanged.

    In plain wordsIn six healthy men, GHRH raised growth hormone more when growth hormone was already rising beforehand than when it was falling or unchanged.

    Peptide
    Sermorelin
    Outcome
    Not applicablePeak GH response to GHRH by prior GH secretory status
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Peak serum GH
    52.9 mU/l
    GH rising before GHRH
    Peak serum GH
    27.5 mU/l
    GH falling before GHRH
    Peak serum GH
    20.6 mU/l
    GH unchanged/undetectable before GHRH

    Source sentences

    Summary
    Peak serum GH concentrations attained were significantly greater when serum GH concentrations were rising (mean 52.9 mU/l, SD 17.2) than if they were falling (mean 27.5 mU/l, SD 13.3) or unchanged/undetectable (mean 20.6 mU/l, SD 9.8) (one-way ANOVA, F = 8.77; P = 0.004).
    2 context sentences
    Summary · context
    one factor influencing the GH response to GHRH was the GH secretory status in the hour prior to the administration of the GHRH.
    Summary · context
    Six normal adult males were given clonidine and GHRH either separately, or in combination, in random order.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In six healthy men, clonidine pretreatment did not augment the peak serum GH response to GHRH.

    In plain wordsIn six healthy men, clonidine beforehand did not increase the growth hormone response to GHRH.

    Peptide
    Sermorelin
    Outcome
    No significant changePeak GH response to GHRH after clonidine pretreatment
    Study

    n = 6

    Comparator
    GHRH given separately
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with clonidine did not augment the peak serum GH response to GHRH
    1 context sentence
    Summary · context
    Six normal adult males were given clonidine and GHRH either separately, or in combination, in random order.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In six healthy men, the direction of the GH response to GHRH was more predictable after clonidine pretreatment than when GHRH was given separately or repeatedly.

    In plain wordsIn six healthy men, the growth hormone response to GHRH was more predictable after clonidine than when GHRH was given alone or repeatedly.

    Peptide
    Sermorelin
    Outcome
    Not applicablePredictability of GH response to GHRH after clonidine pretreatment
    Study

    n = 6

    Comparator
    GHRH given separately or repeatedly
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but the direction of response was more predictable than when GHRH was administered separately or repeatedly.
    1 context sentence
    Summary · context
    Six normal adult males were given clonidine and GHRH either separately, or in combination, in random order.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In six healthy men, prior GHRH(1-29)-NH2 treatment markedly attenuated the peak serum GH response to clonidine.

    In plain wordsIn six healthy men, earlier GHRH treatment greatly reduced the growth hormone response to clonidine.

    Peptide
    Sermorelin
    Outcome
    DecreasePeak GH response to clonidine after prior GHRH treatment
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Prior treatment with GHRH(1-29)-NH2 led to a marked attenuation of the peak serum GH response to clonidine.
    1 context sentence
    Summary · context
    Six normal adult males were given clonidine and GHRH either separately, or in combination, in random order.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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