Reversal of ageing changes in the thymus of rats by chemical or surgical castration.

Kendall MD, Fitzpatrick FT, Greenstein BD, Khoylou F, Safieh B, Hamblin A

Cell and tissue research1 Sept 1990Cited by 44 (Europe PMC)

PMID2147125DOI10.1007/bf00313535PepBankPUB-02147125

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In ageing rats, goserelin significantly increased thymic weight.
In plain wordsIn ageing rats, goserelin increased thymus weight.
Peptide
Goserelin
Outcome
IncreaseThymic weight
Study
ratn: not reported in source
Male CSE Wistar rats
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Both surgical castration and chemical castration induced by a luteinizing hormone-releasing hormone analogue (Goserelin) caused a significant increase in thymic weight and the reappearance of a well-defined cortex and medulla in ageing rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Differences in the thymus of young and old male CSE Wistar rats were examined by use of routine histological stains on paraffin-embedded sections.
Report a problemFND-0214712501
02AnimalAnimal study (in vivo)Activity measurement
In ageing rats, goserelin restored a well-defined thymic cortex and medulla.
In plain wordsIn ageing rats, goserelin restored distinct inner and outer thymus regions.
Peptide
Goserelin
Outcome
IncreaseThymic architecture
Study
ratn: not reported in source
Male CSE Wistar rats
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Both surgical castration and chemical castration induced by a luteinizing hormone-releasing hormone analogue (Goserelin) caused a significant increase in thymic weight and the reappearance of a well-defined cortex and medulla in ageing rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Differences in the thymus of young and old male CSE Wistar rats were examined by use of routine histological stains on paraffin-embedded sections.
Report a problemFND-0214712502
03AnimalAnimal study (in vivo)Activity measurement
In ageing rats, chemical castration with goserelin increased cells positive for the Pan T cell marker.
In plain wordsIn ageing rats, goserelin increased cells with a general T cell marker.
Peptide
Goserelin
Outcome
IncreasePan T cell marker
Study
ratn: not reported in source
Male CSE Wistar rats
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The Pan T cell marker (detected with antibody W3/13) showed fewer positive cells in ageing rats, and an increase after chemical castration.
1 context sentence(design, population, supporting numbers)
Summary · context
Differences in the thymus of young and old male CSE Wistar rats were examined by use of routine histological stains on paraffin-embedded sections.
Report a problemFND-0214712503
04AnimalAnimal study (in vivo)Activity measurement
In young and ageing rats, chemical castration with goserelin increased CD4-positive thymic T cells.
In plain wordsIn young and ageing rats, goserelin increased thymic T cells with the CD4 marker.
Peptide
Goserelin
Outcome
IncreaseCD4-positive T cells
Study
ratn: not reported in source
Male CSE Wistar rats
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The smaller glands of old rats had fewer positive T cells with CD4 (MRC OX35) and CD8 (MRC OX8) antigens, and more after chemical castration in both young and ageing rats, but the greatest changes were seen in the intensity of Class II major histocompatibility complex (MRC OX6) immunoreactivity.
1 context sentence(design, population, supporting numbers)
Summary · context
Differences in the thymus of young and old male CSE Wistar rats were examined by use of routine histological stains on paraffin-embedded sections.
Report a problemFND-0214712504
05AnimalAnimal study (in vivo)Activity measurement
In young and ageing rats, chemical castration with goserelin increased CD8-positive thymic T cells.
In plain wordsIn young and ageing rats, goserelin increased thymic T cells with the CD8 marker.
Peptide
Goserelin
Outcome
IncreaseCD8-positive T cells
Study
ratn: not reported in source
Male CSE Wistar rats
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The smaller glands of old rats had fewer positive T cells with CD4 (MRC OX35) and CD8 (MRC OX8) antigens, and more after chemical castration in both young and ageing rats, but the greatest changes were seen in the intensity of Class II major histocompatibility complex (MRC OX6) immunoreactivity.
1 context sentence(design, population, supporting numbers)
Summary · context
Differences in the thymus of young and old male CSE Wistar rats were examined by use of routine histological stains on paraffin-embedded sections.
Report a problemFND-0214712505
06AnimalAnimal study (in vivo)Activity measurement
In young and ageing rats, goserelin increased the number of Class II MHC-immunoreactive cells in the thymic medulla.
In plain wordsIn young and ageing rats, goserelin increased cells with Class II MHC markers in the inner thymus.
Peptide
Goserelin
Outcome
IncreaseMedullary Class II MHC-positive cells
Study
ratn: not reported in source
Male CSE Wistar rats
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
In both young and ageing chemically-castrated rats, the number of cells and the intensity of immunoreactivity were greatly increased in the medulla.
2 context sentences(design, population, supporting numbers)
Summary · context
The smaller glands of old rats had fewer positive T cells with CD4 (MRC OX35) and CD8 (MRC OX8) antigens, and more after chemical castration in both young and ageing rats, but the greatest changes were seen in the intensity of Class II major histocompatibility complex (MRC OX6) immunoreactivity.
Summary · context
Differences in the thymus of young and old male CSE Wistar rats were examined by use of routine histological stains on paraffin-embedded sections.
Report a problemFND-0214712506
07AnimalAnimal study (in vivo)Activity measurement
In young and ageing rats, goserelin increased Class II MHC immunoreactivity intensity in the thymic medulla.
In plain wordsIn young and ageing rats, goserelin increased Class II MHC staining intensity in the inner thymus.
Peptide
Goserelin
Outcome
IncreaseMedullary Class II MHC immunoreactivity intensity
Study
ratn: not reported in source
Male CSE Wistar rats
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
In both young and ageing chemically-castrated rats, the number of cells and the intensity of immunoreactivity were greatly increased in the medulla.
2 context sentences(design, population, supporting numbers)
Summary · context
The smaller glands of old rats had fewer positive T cells with CD4 (MRC OX35) and CD8 (MRC OX8) antigens, and more after chemical castration in both young and ageing rats, but the greatest changes were seen in the intensity of Class II major histocompatibility complex (MRC OX6) immunoreactivity.
Summary · context
Differences in the thymus of young and old male CSE Wistar rats were examined by use of routine histological stains on paraffin-embedded sections.
Report a problemFND-0214712507

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

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