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Study · Randomized controlled trial · 1990

6 results

A comparison of nafarelin acetate and danazol in the treatment of endometriosis.

Kennedy SH, Williams IA, Brodribb J, Barlow DH, Shaw RW

Fertility and sterility1 Jun 1990Cited by 49 (Europe PMC)

PMID2140996 (opens in a new tab)DOI10.1016/s0015-0282(16)53574-2 (opens in a new tab)PepBankPUB-02140996
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialSafety outcome

    In patients with endometriosis, nafarelin was associated with more hot flushes than danazol.

    In plain wordsIn patients with endometriosis, hot flushes were more frequent with nafarelin than danazol.

    Peptide
    Nafarelin
    Outcome
    IncreaseHot flushes
    Study

    n: not reported in source

    Comparator
    Danazol
    Outcome group
    Adverse events · Whole body
    Studied dose
    400 micrograms daily · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Nafarelin was associated with more hot flushes and headaches, and danazol with more weight gain.
    2 context sentences
    Summary · context
    Nafarelin 400 micrograms daily and danazol 600 mg daily were compared in a double-blind randomized study.
    Summary · context
    Eighty-two patients with endometriosis were treated for 6 months after an initial laparoscopy and 74 had a second laparoscopy.
  2. 02HumanRandomized controlled trialSafety outcome

    In patients with endometriosis, nafarelin was associated with more headaches than danazol.

    In plain wordsIn patients with endometriosis, nafarelin was linked to more headaches than danazol.

    Peptide
    Nafarelin
    Outcome
    IncreaseHeadaches
    Study

    n: not reported in source

    Comparator
    Danazol
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    400 micrograms daily · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Nafarelin was associated with more hot flushes and headaches, and danazol with more weight gain.
    2 context sentences
    Summary · context
    Nafarelin 400 micrograms daily and danazol 600 mg daily were compared in a double-blind randomized study.
    Summary · context
    Eighty-two patients with endometriosis were treated for 6 months after an initial laparoscopy and 74 had a second laparoscopy.
  3. 03HumanRandomized controlled trialSafety outcome

    In patients with endometriosis, nafarelin was associated with less weight gain than danazol.

    In plain wordsIn patients with endometriosis, nafarelin was linked to less weight gain than danazol.

    Peptide
    Nafarelin
    Outcome
    DecreaseWeight gain
    Study

    n: not reported in source

    Comparator
    Danazol
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    400 micrograms daily · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Nafarelin was associated with more hot flushes and headaches, and danazol with more weight gain.
    2 context sentences
    Summary · context
    Nafarelin 400 micrograms daily and danazol 600 mg daily were compared in a double-blind randomized study.
    Summary · context
    Eighty-two patients with endometriosis were treated for 6 months after an initial laparoscopy and 74 had a second laparoscopy.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In patients with endometriosis, treatment efficacy did not differ significantly between nafarelin and danazol.

    In plain wordsIn patients with endometriosis, nafarelin and danazol did not differ significantly in treatment efficacy.

    Peptide
    Nafarelin
    Outcome
    No significant changeTreatment efficacy
    Study

    n: not reported in source

    Comparator
    Danazol
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    400 micrograms daily · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    No significant differences, however, were noted in treatment efficacy between the two groups.
    2 context sentences
    Summary · context
    Nafarelin 400 micrograms daily and danazol 600 mg daily were compared in a double-blind randomized study.
    Summary · context
    Eighty-two patients with endometriosis were treated for 6 months after an initial laparoscopy and 74 had a second laparoscopy.
  5. 05HumanNon-randomized trialEfficacy outcome

    In patients with endometriosis, nafarelin significantly reduced active disease from baseline.

    In plain wordsIn patients with endometriosis, nafarelin reduced active disease from baseline.

    Peptide
    Nafarelin
    Outcome
    DecreaseActive disease regression
    Study

    n: not reported in source

    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    400 micrograms daily · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Both treatments led to significant regression of active disease but not of adhesions.
    2 context sentences
    Summary · context
    Nafarelin 400 micrograms daily and danazol 600 mg daily were compared in a double-blind randomized study.
    Summary · context
    Eighty-two patients with endometriosis were treated for 6 months after an initial laparoscopy and 74 had a second laparoscopy.
  6. 06HumanNon-randomized trialEfficacy outcome

    In patients with endometriosis, nafarelin did not significantly reduce adhesions.

    In plain wordsIn patients with endometriosis, nafarelin did not significantly reduce adhesions.

    Peptide
    Nafarelin
    Outcome
    No significant changeAdhesions
    Study

    n: not reported in source

    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    400 micrograms daily · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Both treatments led to significant regression of active disease but not of adhesions.
    2 context sentences
    Summary · context
    Nafarelin 400 micrograms daily and danazol 600 mg daily were compared in a double-blind randomized study.
    Summary · context
    Eighty-two patients with endometriosis were treated for 6 months after an initial laparoscopy and 74 had a second laparoscopy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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