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Study · Animal study (in vivo) · sheep · 1990

12 results

Effects of enclomiphene on estradiol-induced changes in LH secretion in ewes.

Gregg DW, Nett TM

Journal of animal science1 Oct 1990

PMID2123847 (opens in a new tab)DOI10.2527/1990.68103293x (opens in a new tab)PepBankPUB-02123847
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized ewes, 10 mg enclomiphene suppressed the estradiol-induced LH surge in one of four animals.

    In plain wordsIn ewes with removed ovaries, 10 mg enclomiphene blocked the estradiol-induced LH surge in one of four animals.

    Peptide
    Enclomiphene
    Outcome
    DecreaseEstradiol-induced LH surge suppression
    Study

    sheepn = 4

    ovariectomized ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10 mgAs given in this study (sheep).

    Source sentences

    Summary
    Ten or 25 mg ENC suppressed the estradiol-induced LH surge in one of four ewes, whereas 100- or 250-mg doses suppressed the LH surge in three and four of four ewes, respectively.
    2 context sentences
    Summary · context
    To determine whether ENC could block an estradiol-induced LH surge, ewes (n = 4/group) were administered 10 to 250 mg ENC followed 30 min later by 25 micrograms estradiol.
    Summary · context
    Experiments were conducted to characterize the ability of the antiestrogen enclomiphene (ENC) to block the effects of estradiol on secretion of LH in ovariectomized ewes.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized ewes, 25 mg enclomiphene suppressed the estradiol-induced LH surge in one of four animals.

    In plain wordsIn ewes with removed ovaries, 25 mg enclomiphene blocked the estradiol-induced LH surge in one of four animals.

    Peptide
    Enclomiphene
    Outcome
    DecreaseEstradiol-induced LH surge suppression
    Study

    sheepn = 4

    ovariectomized ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    25 mgAs given in this study (sheep).

    Source sentences

    Summary
    Ten or 25 mg ENC suppressed the estradiol-induced LH surge in one of four ewes, whereas 100- or 250-mg doses suppressed the LH surge in three and four of four ewes, respectively.
    2 context sentences
    Summary · context
    To determine whether ENC could block an estradiol-induced LH surge, ewes (n = 4/group) were administered 10 to 250 mg ENC followed 30 min later by 25 micrograms estradiol.
    Summary · context
    Experiments were conducted to characterize the ability of the antiestrogen enclomiphene (ENC) to block the effects of estradiol on secretion of LH in ovariectomized ewes.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized ewes, 100 mg enclomiphene suppressed the estradiol-induced LH surge in three of four animals.

    In plain wordsIn ewes with removed ovaries, 100 mg enclomiphene blocked the estradiol-induced LH surge in three of four animals.

    Peptide
    Enclomiphene
    Outcome
    DecreaseEstradiol-induced LH surge suppression
    Study

    sheepn = 4

    ovariectomized ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 mgAs given in this study (sheep).

    Source sentences

    Summary
    Ten or 25 mg ENC suppressed the estradiol-induced LH surge in one of four ewes, whereas 100- or 250-mg doses suppressed the LH surge in three and four of four ewes, respectively.
    2 context sentences
    Summary · context
    To determine whether ENC could block an estradiol-induced LH surge, ewes (n = 4/group) were administered 10 to 250 mg ENC followed 30 min later by 25 micrograms estradiol.
    Summary · context
    Experiments were conducted to characterize the ability of the antiestrogen enclomiphene (ENC) to block the effects of estradiol on secretion of LH in ovariectomized ewes.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized ewes, 250 mg enclomiphene suppressed the estradiol-induced LH surge in four of four animals.

    In plain wordsIn ewes with removed ovaries, 250 mg enclomiphene blocked the estradiol-induced LH surge in four of four animals.

    Peptide
    Enclomiphene
    Outcome
    DecreaseEstradiol-induced LH surge suppression
    Study

    sheepn = 4

    ovariectomized ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    250 mgAs given in this study (sheep).

    Source sentences

    Summary
    Ten or 25 mg ENC suppressed the estradiol-induced LH surge in one of four ewes, whereas 100- or 250-mg doses suppressed the LH surge in three and four of four ewes, respectively.
    2 context sentences
    Summary · context
    To determine whether ENC could block an estradiol-induced LH surge, ewes (n = 4/group) were administered 10 to 250 mg ENC followed 30 min later by 25 micrograms estradiol.
    Summary · context
    Experiments were conducted to characterize the ability of the antiestrogen enclomiphene (ENC) to block the effects of estradiol on secretion of LH in ovariectomized ewes.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In ovariectomized ewes, enclomiphene increased pituitary GnRH receptor numbers versus untreated ewes at 12 and 28 days.

    In plain wordsIn ewes with removed ovaries, enclomiphene increased pituitary GnRH receptors versus untreated ewes at 12 and 28 days.

    Peptide
    Enclomiphene
    Outcome
    IncreasePituitary GnRH receptors
    Study

    sheepn: not reported in source

    ovariectomized ewes
    Comparator
    untreated ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 mgAs given in this study (sheep).

    Source sentences

    Summary
    Compared with untreated ewes, the number of pituitary GnRH receptors was elevated (P less than .05) at 12 d and 28 d, but pituitary content of LH had decreased (P less than .05) by 28 d in ewes treated with 100 mg ENC.
    1 context sentence
    Summary · context
    Experiments were conducted to characterize the ability of the antiestrogen enclomiphene (ENC) to block the effects of estradiol on secretion of LH in ovariectomized ewes.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized ewes, enclomiphene decreased pituitary LH content by 28 days versus untreated ewes.

    In plain wordsIn ewes with removed ovaries, enclomiphene reduced pituitary LH content by 28 days versus untreated ewes.

    Peptide
    Enclomiphene
    Outcome
    DecreasePituitary LH content
    Study

    sheepn: not reported in source

    ovariectomized ewes
    Comparator
    untreated ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 mgAs given in this study (sheep).

    Source sentences

    Summary
    Compared with untreated ewes, the number of pituitary GnRH receptors was elevated (P less than .05) at 12 d and 28 d, but pituitary content of LH had decreased (P less than .05) by 28 d in ewes treated with 100 mg ENC.
    1 context sentence
    Summary · context
    Experiments were conducted to characterize the ability of the antiestrogen enclomiphene (ENC) to block the effects of estradiol on secretion of LH in ovariectomized ewes.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized ewes, .03 mg enclomiphene alone did not affect serum LH concentrations.

    In plain wordsIn ewes with removed ovaries, .03 mg enclomiphene alone did not change blood LH levels.

    Peptide
    Enclomiphene
    Outcome
    No significant changeSerum LH concentration
    Study

    sheepn: not reported in source

    ovariectomized ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    .03 mg every 4 d · injectionAs given in this study (sheep).

    Source sentences

    Summary
    Injection of .03, .1 or 1 mg ENC alone did not affect serum concentrations of LH, whereas the 10-mg dose decreased serum concentrations of LH below 1 ng/ml by wk 1 of treatment.
    2 context sentences
    Summary · context
    To determine whether ENC could block the inhibitory effects of estradiol on serum concentrations of LH, ewes received injections of .03, .1, 1 or 10 mg ENC every 4 d.
    Summary · context
    Experiments were conducted to characterize the ability of the antiestrogen enclomiphene (ENC) to block the effects of estradiol on secretion of LH in ovariectomized ewes.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized ewes, .1 mg enclomiphene alone did not affect serum LH concentrations.

    In plain wordsIn ewes with removed ovaries, .1 mg enclomiphene alone did not change blood LH levels.

    Peptide
    Enclomiphene
    Outcome
    No significant changeSerum LH concentration
    Study

    sheepn: not reported in source

    ovariectomized ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    .1 mg every 4 d · injectionAs given in this study (sheep).

    Source sentences

    Summary
    Injection of .03, .1 or 1 mg ENC alone did not affect serum concentrations of LH, whereas the 10-mg dose decreased serum concentrations of LH below 1 ng/ml by wk 1 of treatment.
    2 context sentences
    Summary · context
    To determine whether ENC could block the inhibitory effects of estradiol on serum concentrations of LH, ewes received injections of .03, .1, 1 or 10 mg ENC every 4 d.
    Summary · context
    Experiments were conducted to characterize the ability of the antiestrogen enclomiphene (ENC) to block the effects of estradiol on secretion of LH in ovariectomized ewes.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized ewes, 1 mg enclomiphene alone did not affect serum LH concentrations.

    In plain wordsIn ewes with removed ovaries, 1 mg enclomiphene alone did not change blood LH levels.

    Peptide
    Enclomiphene
    Outcome
    No significant changeSerum LH concentration
    Study

    sheepn: not reported in source

    ovariectomized ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 mg every 4 d · injectionAs given in this study (sheep).

    Source sentences

    Summary
    Injection of .03, .1 or 1 mg ENC alone did not affect serum concentrations of LH, whereas the 10-mg dose decreased serum concentrations of LH below 1 ng/ml by wk 1 of treatment.
    2 context sentences
    Summary · context
    To determine whether ENC could block the inhibitory effects of estradiol on serum concentrations of LH, ewes received injections of .03, .1, 1 or 10 mg ENC every 4 d.
    Summary · context
    Experiments were conducted to characterize the ability of the antiestrogen enclomiphene (ENC) to block the effects of estradiol on secretion of LH in ovariectomized ewes.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized ewes, 10 mg enclomiphene alone decreased serum LH below 1 ng/ml by treatment week 1.

    In plain wordsIn ewes with removed ovaries, 10 mg enclomiphene alone reduced blood LH below 1 ng/ml by week 1.

    Peptide
    Enclomiphene
    Outcome
    DecreaseSerum LH concentration
    Study

    sheepn: not reported in source

    ovariectomized ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10 mg every 4 d · injectionAs given in this study (sheep).

    Measurements

    Serum LH
    < 1 ng/ml
    10 mg ENC by wk 1

    Source sentences

    Summary
    Injection of .03, .1 or 1 mg ENC alone did not affect serum concentrations of LH, whereas the 10-mg dose decreased serum concentrations of LH below 1 ng/ml by wk 1 of treatment.
    2 context sentences
    Summary · context
    To determine whether ENC could block the inhibitory effects of estradiol on serum concentrations of LH, ewes received injections of .03, .1, 1 or 10 mg ENC every 4 d.
    Summary · context
    Experiments were conducted to characterize the ability of the antiestrogen enclomiphene (ENC) to block the effects of estradiol on secretion of LH in ovariectomized ewes.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized ewes, no enclomiphene dose prevented serum LH inhibition caused by estradiol implants.

    In plain wordsIn ewes with removed ovaries, no enclomiphene dose prevented blood LH suppression from estradiol implants.

    Peptide
    Enclomiphene
    Outcome
    No significant changePrevention of estradiol-induced LH inhibition
    Study

    sheepn: not reported in source

    ovariectomized ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    .03, .1, 1 or 10 mg every 4 d · injectionAs given in this study (sheep).

    Source sentences

    Summary
    No dose prevented the inhibition of serum concentrations of LH caused by estradiol implants.
    3 context sentences
    Summary · context
    To determine whether ENC could block the inhibitory effects of estradiol on serum concentrations of LH, ewes received injections of .03, .1, 1 or 10 mg ENC every 4 d.
    Summary · context
    Half the ewes treated with each dose also received estradiol implants.
    Summary · context
    Experiments were conducted to characterize the ability of the antiestrogen enclomiphene (ENC) to block the effects of estradiol on secretion of LH in ovariectomized ewes.

Studies that did not test the peptide alone1

In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Enclomiphene.

  1. 12AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized ewes, a single enclomiphene plus estradiol treatment maintained serum LH below 1 ng/ml for 3 weeks.

    In plain wordsIn ewes with removed ovaries, enclomiphene plus estradiol maintained blood LH below 1 ng/ml for 3 weeks.

    Peptide
    Enclomiphene
    Outcome
    Direction not reportedSustained serum LH concentration
    Study

    sheepn: not reported in source

    ovariectomized ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Measurements

    Serum LH
    < 1 ng/ml
    100 mg ENC plus 25 micrograms estradiol

    Source sentences

    Summary
    In ewes that received a single treatment of 100 mg ENC plus 25 micrograms estradiol, serum concentrations of LH remained below 1 ng/ml for 3 wk.
    1 context sentence
    Summary · context
    Experiments were conducted to characterize the ability of the antiestrogen enclomiphene (ENC) to block the effects of estradiol on secretion of LH in ovariectomized ewes.

    In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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Terms as the source lists them.

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