Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone.

Bowers CY, Reynolds GA, Durham D, Barrera CM, Pezzoli SS, Thorner MO

The Journal of clinical endocrinology and metabolism1 Apr 1990Cited by 163 (Europe PMC)

PMID2108187DOI10.1210/jcem-70-4-975PepBankPUB-02108187

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

8 results from studies that gave the peptide. 8 results from people.

01HumanNon-randomized trialEfficacy outcome
In normal men, an intravenous bolus of GHRP at 0.1 microgram/kg raised mean peak serum GH to 7.6 micrograms/L, against 1.2 micrograms/L after placebo.
In plain wordsIn healthy men, a low dose of GHRP raised growth hormone peaks above placebo.
Peptide
GHRP-6
Outcome
IncreasePeak serum GH after GHRP 0.1 microgram/kg
Study
n = 18
Comparator
Placebo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.1 microgram/kg · intravenous bolusAs given in this study (human).
Measurements
Mean peak serum GH
7.6 micrograms/L
GHRP 0.1 microgram/kg
Mean peak serum GH
1.2 micrograms/L
placebo
Source sentences
Summary
Mean (+/- SEM) peak serum GH levels after injection of placebo and 0.1, 0.3, and 1.0 microgram/kg GHRP were 1.2 +/- 0.3, 7.6 +/- 2.5, 16.5 +/- 4.1, and 68.7 +/- 15.5 micrograms/L, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2.
Summary · context
GHRP was administered at doses of 0.1, 0.3, and 1.0 microgram/kg by iv bolus.
Report a problemFND-0210818701
02HumanNon-randomized trialEfficacy outcome
In normal men, an intravenous bolus of GHRP at 0.3 microgram/kg raised mean peak serum GH to 16.5 micrograms/L, against 1.2 micrograms/L after placebo.
In plain wordsIn healthy men, a middle dose of GHRP raised growth hormone peaks above placebo.
Peptide
GHRP-6
Outcome
IncreasePeak serum GH after GHRP 0.3 microgram/kg
Study
n = 18
Comparator
Placebo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.3 microgram/kg · intravenous bolusAs given in this study (human).
Measurements
Mean peak serum GH
16.5 micrograms/L
GHRP 0.3 microgram/kg
Mean peak serum GH
1.2 micrograms/L
placebo
Source sentences
Summary
Mean (+/- SEM) peak serum GH levels after injection of placebo and 0.1, 0.3, and 1.0 microgram/kg GHRP were 1.2 +/- 0.3, 7.6 +/- 2.5, 16.5 +/- 4.1, and 68.7 +/- 15.5 micrograms/L, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2.
Summary · context
GHRP was administered at doses of 0.1, 0.3, and 1.0 microgram/kg by iv bolus.
Report a problemFND-0210818702
03HumanNon-randomized trialEfficacy outcome
In normal men, an intravenous bolus of GHRP at 1.0 microgram/kg raised mean peak serum GH to 68.7 micrograms/L, against 1.2 micrograms/L after placebo.
In plain wordsIn healthy men, the highest GHRP dose raised growth hormone peaks far above placebo.
Peptide
GHRP-6
Outcome
IncreasePeak serum GH after GHRP 1.0 microgram/kg
Study
n = 18
Comparator
Placebo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1.0 microgram/kg · intravenous bolusAs given in this study (human).
Measurements
Mean peak serum GH
68.7 micrograms/L
GHRP 1.0 microgram/kg
Mean peak serum GH
1.2 micrograms/L
placebo
Source sentences
Summary
Mean (+/- SEM) peak serum GH levels after injection of placebo and 0.1, 0.3, and 1.0 microgram/kg GHRP were 1.2 +/- 0.3, 7.6 +/- 2.5, 16.5 +/- 4.1, and 68.7 +/- 15.5 micrograms/L, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2.
Summary · context
GHRP was administered at doses of 0.1, 0.3, and 1.0 microgram/kg by iv bolus.
Report a problemFND-0210818703
04HumanNon-randomized trialSafety outcome
In normal men, no adverse clinical effects or laboratory abnormalities were observed in response to GHRP.
In plain wordsIn healthy men, GHRP caused no adverse clinical effects or laboratory abnormalities in this short study.
Peptide
GHRP-6
Outcome
No significant changeAdverse clinical effects and laboratory abnormalities
Study
n = 18
Outcome group
Adverse events · Whole body
Studied dose
0.1, 0.3 and 1.0 microgram/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
No adverse clinical effects of laboratory abnormalities were observed in response to GHRP.
2 context sentences(design, population, supporting numbers)
Summary · context
The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2.
Summary · context
GHRP was administered at doses of 0.1, 0.3, and 1.0 microgram/kg by iv bolus.
Report a problemFND-0210818705
05HumanNon-randomized trialActivity measurement
In normal men, serum prolactin rose about 2-fold above basal levels at the GHRP dose of 1 microgram/kg only.
In plain wordsIn healthy men, the highest GHRP dose raised prolactin about 2-fold above its starting level.
Peptide
GHRP-6
Outcome
IncreaseSerum prolactin after GHRP 1 microgram/kg
Study
n = 18
Comparator
Basal level
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
1 microgram/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
Serum PRL and cortisol levels rose about 2-fold above basal levels only at the 1 microgram/kg dose of GHRP
2 context sentences(design, population, supporting numbers)
Summary · context
The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2.
Summary · context
GHRP was administered at doses of 0.1, 0.3, and 1.0 microgram/kg by iv bolus.
Report a problemFND-0210818706
06HumanNon-randomized trialActivity measurement
In normal men, serum cortisol rose about 2-fold above basal levels at the GHRP dose of 1 microgram/kg only.
In plain wordsIn healthy men, the highest GHRP dose raised cortisol about 2-fold above its starting level.
Peptide
GHRP-6
Outcome
IncreaseSerum cortisol after GHRP 1 microgram/kg
Study
n = 18
Comparator
Basal level
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
1 microgram/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
Serum PRL and cortisol levels rose about 2-fold above basal levels only at the 1 microgram/kg dose of GHRP
2 context sentences(design, population, supporting numbers)
Summary · context
The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2.
Summary · context
GHRP was administered at doses of 0.1, 0.3, and 1.0 microgram/kg by iv bolus.
Report a problemFND-0210818707
07HumanNon-randomized trialActivity measurement
In normal men, serum LH did not change over the first hour after GHRP and GHRH administration.
In plain wordsIn healthy men, luteinising hormone did not change in the first hour after GHRP.
Peptide
GHRP-6
Outcome
No significant changeSerum LH over the first hour
Study
n = 18
Comparator
Basal level
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.1, 0.3 and 1.0 microgram/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
there were no changes in serum LH and TSH over the first hour after administration of the peptide(s).
2 context sentences(design, population, supporting numbers)
Summary · context
The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2.
Summary · context
GHRP was administered at doses of 0.1, 0.3, and 1.0 microgram/kg by iv bolus.
Report a problemFND-0210818708
08HumanNon-randomized trialActivity measurement
In normal men, serum TSH did not change over the first hour after GHRP and GHRH administration.
In plain wordsIn healthy men, thyroid-stimulating hormone did not change in the first hour after GHRP.
Peptide
GHRP-6
Outcome
No significant changeSerum TSH over the first hour
Study
n = 18
Comparator
Basal level
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
0.1, 0.3 and 1.0 microgram/kg · intravenous bolusAs given in this study (human).
Source sentences
Summary
there were no changes in serum LH and TSH over the first hour after administration of the peptide(s).
2 context sentences(design, population, supporting numbers)
Summary · context
The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2.
Summary · context
GHRP was administered at doses of 0.1, 0.3, and 1.0 microgram/kg by iv bolus.
Report a problemFND-0210818709

Studies that did not test the peptide alone1

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

09HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome
In normal men, GHRP at 0.1 and 0.3 microgram/kg given together with GHRH at 1 microgram/kg stimulated GH release synergistically.
In plain wordsIn healthy men, a low dose of GHRP given together with GHRH released growth hormone synergistically.
Peptide
GHRP-6
Outcome
IncreaseGH release with GHRP plus GHRH
Study
n = 18
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
The submaximal dosages of 0.1 and 0.3 microgram/kg GHRP plus 1 microgram/kg GHRH stimulated GH release synergistically.
2 context sentences(design, population, supporting numbers)
Summary · context
The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1-44)-NH2.
Summary · context
GHRP was administered at doses of 0.1, 0.3, and 1.0 microgram/kg by iv bolus.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0210818704

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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