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Study · Animal study (in vivo) · rat · 1990

2 results

Effects of testosterone and growth hormone treatment on hepatic microsomal P450 expression in the diabetic rat.

Thummel KE, Schenkman JB

Molecular pharmacology1 Jan 1990Cited by 59 (Europe PMC)

PMID2105452 (opens in a new tab)DOI10.1016/s0026-895x(25)09941-9 (opens in a new tab)PepBankPUB-02105452
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In diabetic male rats, human GH did not significantly reverse the diabetes-induced change in hepatic P450 IIC11.

    In plain wordsIn diabetic male rats, human GH did not significantly reverse the diabetes-related change in liver P450 IIC11.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeHepatic P450 IIC11
    Study

    ratn: not reported in source

    Diabetic male rats
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · intravenous every 4 hr · 1 weekAs given in this study (rat).

    Source sentences

    Summary
    However, 1 week of human growth hormone, administered intravenously every 4 hr to diabetic male rats, failed to significantly reverse the diabetes-induced changes in hepatic cytochromes P450, in particular forms IIC11 and IIE1, despite the presence of an episodic plasma hGH profile.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In diabetic male rats, human GH did not significantly reverse the diabetes-induced change in hepatic P450 IIE1.

    In plain wordsIn diabetic male rats, human GH did not significantly reverse the diabetes-related change in liver P450 IIE1.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeHepatic P450 IIE1
    Study

    ratn: not reported in source

    Diabetic male rats
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · intravenous every 4 hr · 1 weekAs given in this study (rat).

    Source sentences

    Summary
    However, 1 week of human growth hormone, administered intravenously every 4 hr to diabetic male rats, failed to significantly reverse the diabetes-induced changes in hepatic cytochromes P450, in particular forms IIC11 and IIE1, despite the presence of an episodic plasma hGH profile.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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