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Study · Animal study (in vivo) · rat · 1990

2 results

[The effect of thymogen on the cell division processes in the corneal epithelium under physiological conditions and in an experimental thermal burn].

Koz'mova TS

Oftalmologicheskii zhurnal1 Jan 1990

PMID2100778 (opens in a new tab)PepBankPUB-02100778
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In intact rats, systemic and local thymogene induced corneal epithelial DNA synthesis, most strongly by the 3d-5th day.

    In plain wordsIn intact rats, systemic and local thymogene stimulated DNA synthesis in corneal cells, most strongly by the 3d-5th day.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseCorneal epithelial DNA synthesis
    Study

    ratn: not reported in source

    Intact rats
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated · systemic and localAs given in this study (rat).

    Source sentences

    Summary
    (280 eyes) have shown that in intact animals the preparation produces DNA synthesis in both systemic and local usage, that is most expressed by the 3d-5th day after its administration.
    1 context sentence
    Summary · context
    Experimental studies of the influence of a new pharmacologic preparation thymogene on the processes of cellular multiplication of the corneal epithelium in physiologic conditions and thermic burn of the eye in 140 rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with corneal burns, thymogene stimulated corneal epithelial cellular population on the 3d day and by the 14th day.

    In plain wordsIn rats with corneal burns, thymogene stimulated corneal cell population on the 3d day and by the 14th day.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseCorneal epithelial cellular population
    Study

    ratn: not reported in source

    Thermal corneal burn
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The study of the influence of thymogene on reparative processes in rats with corneal burns has shown that administration of the preparation stimulates processes of cellular population in the corneal epithelium both in the early period (on the 3d day) and by the 14th day after burn trauma.
    1 context sentence
    Summary · context
    Experimental studies of the influence of a new pharmacologic preparation thymogene on the processes of cellular multiplication of the corneal epithelium in physiologic conditions and thermic burn of the eye in 140 rats.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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