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Study · Animal study (in vivo) · rat · 1990

2 results

[The effect of thymosin fraction 5 and its synthetic component thymosin-alpha 1 on rat open-field behavior].

Boldyrev AM, Orbachevskaia IIu, Mitrokhina SS

Farmakologiia i toksikologiia1 Nov 1990Cited by 1 (Europe PMC)

PMID2081558 (opens in a new tab)PepBankPUB-02081558
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats, intracerebroventricular thymosin alpha‑1 at 10 ng suppressed open-field motor activity for about 0.5 hour.

    In plain wordsIn rats, thymosin alpha‑1 given into the brain ventricles lowered movement for about half an hour.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseMotor activity in the open field
    Study

    ratn: not reported in source

    Wistar rats, open field
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    10 ng · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    at i. c. v. administration of both compounds in a dose of 10 ng the motor activity was suppressed for about 0.5 hour.
    1 context sentence
    Summary · context
    The effect of thymosin fraction 5 and its synthetic component thymosin-alpha 1 administered i. p. and i. c. v. on the behavior of 219 Wistar rats in the open field was studied to establish the effective dose and time of action of both substances.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats, thymosin alpha‑1 and thymosin fraction 5 influenced open-field motor activity in a similar way irrespective of the route of administration.

    In plain wordsIn rats, thymosin alpha‑1 and thymosin fraction 5 changed movement in a similar way whether given into the belly or the brain.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseMotor activity in the open field
    Study

    ratn: not reported in source

    Wistar rats, open field
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal and intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Both peptides influence in a similar way the motor activity of the animals irrespective of the route of administration.
    1 context sentence
    Summary · context
    The effect of thymosin fraction 5 and its synthetic component thymosin-alpha 1 administered i. p. and i. c. v. on the behavior of 219 Wistar rats in the open field was studied to establish the effective dose and time of action of both substances.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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