Skip to content

Study · Measured the body's own peptide · 1990

3 results

Sex-related differences and thyroid hormone regulation of vasoactive intestinal peptide gene expression in the rat brain and pituitary.

Lam KS, Srivastava G

Brain research1 Aug 1990Cited by 16 (Europe PMC)

PMID2078813 (opens in a new tab)DOI10.1016/0006-8993(90)90259-e (opens in a new tab)PepBankPUB-02078813
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, hypothyroidism increased VIP mRNA level in the pituitary versus control.

    In plain wordsIn rats, an underactive thyroid raised the body's own VIP messenger RNA in the pituitary gland compared with control rats.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreasePituitary VIP mRNA in hypothyroid rats
    Study

    ratn: not reported in source

    anterior pituitary
    Comparator
    Control rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    A tissue-specific increase in VIP mRNA level was observed in the hypothyroid pituitary.
    1 context sentence
    Summary · context
    To determine the effects of hypothyroidism and sexual dimorphism on the gene expression of vasoactive intestinal peptide (VIP) in the rat brain, VIP mRNA levels were measured in the cerebral cortex, hypothalamus and anterior pituitary of control and hypothyroid (thionamide-treated) rats.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, VIP mRNA levels were higher in the pituitaries of males than of females.

    In plain wordsIn rats, the body's own VIP messenger RNA in the pituitary was higher in males than in females.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreasePituitary VIP mRNA by sex
    Study

    ratn: not reported in source

    anterior pituitary
    Comparator
    Female rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    In addition, higher levels of VIP mRNA were found in the pituitaries of male rats suggesting a sex-related difference in VIP gene expression.
    1 context sentence
    Summary · context
    To determine the effects of hypothyroidism and sexual dimorphism on the gene expression of vasoactive intestinal peptide (VIP) in the rat brain, VIP mRNA levels were measured in the cerebral cortex, hypothalamus and anterior pituitary of control and hypothyroid (thionamide-treated) rats.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, similar differences in VIP mRNA level were not observed in the cortex or hypothalamus.

    In plain wordsIn rats, the body's own VIP messenger RNA in the cortex and hypothalamus did not show the same differences.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeVIP mRNA in cortex and hypothalamus
    Study

    ratn: not reported in source

    cerebral cortex and hypothalamus
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Similar differences were not observed in the cortex or hypothalamus.
    1 context sentence
    Summary · context
    To determine the effects of hypothyroidism and sexual dimorphism on the gene expression of vasoactive intestinal peptide (VIP) in the rat brain, VIP mRNA levels were measured in the cerebral cortex, hypothalamus and anterior pituitary of control and hypothyroid (thionamide-treated) rats.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.