The [D-Arg30]prothymosin alpha fragment 1-30 analog retained activity on the impaired blastogenic response of T-lymphocytes from uremic patients.
In plain wordsIn lab tests on immune cells, the modified fragment kept its activity.
- Peptide
- Thymosin alpha-1
- Outcome
- No significant changeRestoration of blastogenic response by the fragment analog
- Study
humann: not reported in source
T-lymphocytes isolated from uremic patients; human serum incubation- Comparator
- Deacetyl-thymosin alpha 1
- Outcome group
- Immune response · Immune and inflammation
Source sentences
the fragment analog, [D-Arg30]prothymosin alpha fragment 1-30 retained activity
2 context sentences(design, population, supporting numbers)
Deacetyl-thymosin alpha 1, a synthetic octaeicosapeptide corresponding to deacetyl-prothymosin alpha fragment 1-28, has restoration ability for the impaired blastogenic response of T-lymphocytes of uremic patients but is susceptible to proteolytic digestion
A fragment analog, [D-Arg30]prothymosin alpha fragment 1-30, containing D-arginine in place of arginine residue at position 30 was synthesized by the liquid phase procedure and studied for immunological effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients after…
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.