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Study · Measured the body's own peptide · 1991

3 results

Light and electron microscopic immunocytochemical evidence that delta sleep-inducing peptide and gonadotropin-releasing hormone are coexpressed in the same nerve structures in the guinea pig median eminence.

Pu LP, Charnay Y, Leduque P, Morel G, Dubois PM

Neuroendocrinology1 Apr 1991Cited by 8 (Europe PMC)

PMID2046867 (opens in a new tab)DOI10.1159/000125738 (opens in a new tab)PepBankPUB-02046867
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the guinea pig median eminence, the distribution patterns of the body's own DSIP and GnRH immunoreactivity were indistinguishable by light microscopy.

    In plain wordsIn guinea pigs, the body's own DSIP and GnRH showed the same distribution in the median eminence under the light microscope.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP and GnRH immunoreactivity distribution at light microscopic level
    Study

    guinea pign: not reported in source

    Median eminence sections, light and electron microscopic immunocytochemistry
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Indirect immunofluorescence and elution-restaining experiments show that at the light microscopic level the distribution patterns of DSIP and GnRH immunoreactivity are indistinguishable.
    1 context sentence
    Summary · context
    The relationships between delta sleep-inducing peptide (DSIP) and GnRH immunoreactivity within the guinea pig median eminence are investigated by light and electron microscopic immunocytochemistry.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the guinea pig median eminence, the body's own DSIP and GnRH immunoreactivity were frequently colocalized within single secretory granules.

    In plain wordsIn guinea pigs, the body's own DSIP and GnRH were often found together in the same secretory granules.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP and GnRH colocalization in secretory granules
    Study

    guinea pign: not reported in source

    Median eminence sections, light and electron microscopic immunocytochemistry
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    At the electron microscopic level, a preembedding double-immunolabeling technique using both indirect immunoperoxidase and immunogold methods, clearly indicate that DSIP and GnRH immunoreactivity are frequently colocalized within single secretory granules.
    1 context sentence
    Summary · context
    The relationships between delta sleep-inducing peptide (DSIP) and GnRH immunoreactivity within the guinea pig median eminence are investigated by light and electron microscopic immunocytochemistry.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the guinea pig median eminence, nerve endings with the body's own DSIP and GnRH immunoreactivity were often close to tanycyte elements.

    In plain wordsIn guinea pigs, nerve endings with the body's own DSIP and GnRH were often next to tanycyte cells.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP/GnRH nerve endings near tanycytes
    Study

    guinea pign: not reported in source

    Median eminence sections, light and electron microscopic immunocytochemistry
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    In addition DSIP/GnRH immunoreactive nerve endings were also observed often in close proximity to tanycyte elements.
    1 context sentence
    Summary · context
    The relationships between delta sleep-inducing peptide (DSIP) and GnRH immunoreactivity within the guinea pig median eminence are investigated by light and electron microscopic immunocytochemistry.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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